Overexpression of Pyruvate Kinase Type M2 (PKM2) Promotes Ovarian Cancer Cell Growth and Survival Via Regulation of Cell Cycle Progression Related with Upregulated CCND1 and Downregulated CDKN1A Expression.

scientific article

Overexpression of Pyruvate Kinase Type M2 (PKM2) Promotes Ovarian Cancer Cell Growth and Survival Via Regulation of Cell Cycle Progression Related with Upregulated CCND1 and Downregulated CDKN1A Expression. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.12659/MSM.907490
P932PMC publication ID5973491
P698PubMed publication ID29752805

P2093author name stringKai Wang
Bin Zheng
Li Zeng
Fangfang Liu
Li Geng
Qiaojia Huang
Xiaojuan Ouyang
P2860cites workPinX1 suppresses bladder urothelial carcinoma cell proliferation via the inhibition of telomerase activity and p16/cyclin D1 pathwayQ21245756
Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growthQ24603549
In 2014, can we do better than CA125 in the early detection of ovarian cancer?Q26825152
Pyruvate kinase M2 is a phosphotyrosine-binding proteinQ27650067
Marker for renal cell carcinoma (RCC): the dimeric form of pyruvate kinase type M2 (Tu M2-PK)Q28143504
The significance of TU M2-PK tumor marker for lung cancer diagnosticsQ28249860
Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regressionQ34136997
Evidence for an alternative glycolytic pathway in rapidly proliferating cellsQ34535762
Akt2 kinase suppresses glyceraldehyde-3-phosphate dehydrogenase (GAPDH)-mediated apoptosis in ovarian cancer cells via phosphorylating GAPDH at threonine 237 and decreasing its nuclear translocationQ35604944
Nuclear PKM2 regulates β-catenin transactivation upon EGFR activationQ35607137
Extracellular PKM2 induces cancer proliferation by activating the EGFR signaling pathwayQ36853866
SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor GrowthQ37059824
PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesisQ37157031
AKT-induced PKM2 phosphorylation signals for IGF-1-stimulated cancer cell growthQ37565415
Multiple roles of the cell cycle inhibitor p21(CDKN1A) in the DNA damage response.Q37680260
PKM2 contributes to cancer metabolismQ38186334
Improving Prospects for Targeting RAS.Q38586951
Identification of a cyclin D1 network in prostate cancer that antagonizes epithelial-mesenchymal restraintQ39053619
Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cellsQ39124362
Pyruvate kinase type M2 is upregulated in colorectal cancer and promotes proliferation and migration of colon cancer cellsQ39312837
Pyruvate kinase M2 promotes the growth of gastric cancer cells via regulation of Bcl-xL expression at transcriptional levelQ39342712
Reduced p21(WAF1/CIP1) via alteration of p53-DDX3 pathway is associated with poor relapse-free survival in early-stage human papillomavirus-associated lung cancerQ39591325
HER-2/neu overexpression is an independent prognostic factor for intestinal-type and early-stage gastric cancer patients.Q54551877
Quantification of tumor type M2 pyruvate kinase (Tu M2-PK) in human carcinomasQ73786026
P921main subjectovarian cancerQ172341
cell growthQ189159
overexpressionQ61643320
P1104number of pages10
P304page(s)3103-3112
P577publication date2018-05-12
P1433published inMedical Science MonitorQ15756323
P1476titleOverexpression of Pyruvate Kinase Type M2 (PKM2) Promotes Ovarian Cancer Cell Growth and Survival Via Regulation of Cell Cycle Progression Related with Upregulated CCND1 and Downregulated CDKN1A Expression.
P478volume24

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cites work (P2860)
Q64055362A Comparative Study of Biological Characteristics and Transcriptome Profiles of Mesenchymal Stem Cells from Different Canine Tissues
Q92340166Cancer-associated fibroblast-derived exosomal microRNA-98-5p promotes cisplatin resistance in ovarian cancer by targeting CDKN1A
Q89942278Experimental Study of Hepatocellular Carcinoma Treatment by Shikonin Through Regulating PKM2
Q91584484The role of pyruvate kinase M2 in anticancer therapeutic treatments

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