The role of IL-12 in inflammatory activity of patients with rheumatoid arthritis (RA).

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The role of IL-12 in inflammatory activity of patients with rheumatoid arthritis (RA). is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1046/J.1365-2249.2000.01095.X
P932PMC publication ID1905529
P698PubMed publication ID10606980
P5875ResearchGate publication ID51353244

P2093author name stringS Park
S Lee
M Cho
H Kim
W Kim
J Youn
S Min
J Min
C Cho
P2860cites workHuman IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activityQ24306484
Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factorQ24338518
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Tumour necrosis factor in serum and synovial fluid of patients with active and severe rheumatoid arthritisQ33562931
Administration of interleukin 12 in combination with type II collagen induces severe arthritis in DBA/1 miceQ34266204
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Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritisQ34566660
Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samplesQ35348875
Serum interleukin 12 concentration in juvenile chronic arthritisQ35547995
TNF alpha--a pivotal role in rheumatoid arthritis?Q36092239
Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblastsQ36351406
Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cellsQ36362214
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T helper phenotype and genetic susceptibility in experimental Lyme diseaseQ36364505
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Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hostsQ36394980
Heterogeneity of cytokine secretion patterns and functions of helper T cellsQ38257524
The American College of Rheumatology preliminary core set of disease activity measures for rheumatoid arthritis clinical trials. The Committee on Outcome Measures in Rheumatoid Arthritis Clinical TrialsQ40914450
Recombinant interleukin-12 suppresses the synthesis of immunoglobulin E by interleukin-4 stimulated human lymphocytesQ41020266
Interleukin-12/T cell stimulating factor, a cytokine with multiple effects on T helper type 1 (Th1) but not on Th2 cellsQ41539687
B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapyQ42675165
American College of Rheumatology. Preliminary definition of improvement in rheumatoid arthritisQ47643186
Increased release of interleukin-12p40 in MS: association with intracerebral inflammationQ48390502
Expression of interleukin-12 in synovial tissue from patients with rheumatoid arthritisQ57081069
Inhibition of the human allogeneic mixed lymphocyte response by cyclosporin A: relationship with the IL-12 pathwayQ58621154
Blockade of IL-12 during the induction of collagen-induced arthritis (CIA) markedly attenuates the severity of the arthritisQ60461800
Serum interleukin-12 levels in patients with multiple sclerosisQ61913051
Effects of interleukin-6 on the metabolism of connective tissue components in rheumatoid synovial fibroblastsQ67569079
Human TH1 and TH2 subsets: doubt no moreQ68316539
Altered cytokine activity in adjuvant inhibition of autoimmune diabetesQ70477284
Expression of interferon-gamma (IFN-gamma), IL-10, IL-12 and transforming growth factor-beta (TGF-beta) mRNA in synovial fluid cells from patients in the early and late phases of rheumatoid arthritis (RA)Q71018485
Different cytokine profiles in the synovial fluid of patients with osteoarthritis, rheumatoid arthritis and seronegative spondylarthropathiesQ71339960
Interleukin 12 mRNA expression in islets correlates with beta-cell destruction in NOD miceQ71811775
In vitro expression of activation markers and lymphocyte proliferation in response to interleukin 12: effect of immunosuppressive agentsQ71878928
Reduced incidence and severity of collagen-induced arthritis in interleukin-12-deficient miceQ71930242
Induction and prevention of colonic inflammation in IL-2-deficient miceQ71968278
Recombinant IL-12 administration induces tumor regression in association with IFN-gamma productionQ72686394
Increased interleukin-12 plasma concentrations in both, insulin-dependent and non-insulin-dependent diabetes mellitusQ74485864
Interleukin-12 is expressed by infiltrating macrophages and synovial lining cells in rheumatoid arthritis and osteoarthritisQ77359149
P433issue1
P921main subjectpatientQ181600
rheumatoid arthritisQ187255
inflammationQ101991
P304page(s)175-181
P577publication date2000-01-01
P1433published inClinical and Experimental ImmunologyQ15716708
P1476titleThe role of IL-12 in inflammatory activity of patients with rheumatoid arthritis (RA).
P478volume119

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cites work (P2860)
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Q37316594Evidence that cytokines play a role in rheumatoid arthritis
Q39029766Human secreted stabilin-1-interacting chitinase-like protein aggravates the inflammation associated with rheumatoid arthritis and is a potential macrophage inflammatory regulator in rodents
Q51298173IL-12B Gene Polymorphisms and IL-12 p70 Serum Levels Among Patients with Rheumatoid Arthritis.
Q80473556Immune complex-stimulated production of interleukin-12 in peripheral blood mononuclear cells is regulated by the complement system
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