Contribution of O6‐methylguanine‐DNA methyltransferase to resistance to 1,3‐(2‐chloroethyl)‐1‐nitrosourea in human brain tumor‐derived cell lines

scientific article published on June 1, 1995

Contribution of O6‐methylguanine‐DNA methyltransferase to resistance to 1,3‐(2‐chloroethyl)‐1‐nitrosourea in human brain tumor‐derived cell lines is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/MC.2940130204
P953full work available at URLhttps://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fmc.2940130204
https://onlinelibrary.wiley.com/doi/pdf/10.1002/mc.2940130204
P698PubMed publication ID7605583

P2093author name stringM. S. Berger
J. R. Silber
M. S. Bobola
P2860cites workExpression of human O6-methylguanine-DNA methyltransferase in Chinese hamster ovary cells and restoration of cellular resistance to certain N-nitroso compounds.Q53502595
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Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme.Q54255608
Expression in mammalian cells of a truncated Escherichia coli gene coding for O6-alkylguanine alkyltransferase reduces the toxic effects of alkylating agents.Q54331120
Overexpression of metallothionein confers resistance to anticancer drugs.Q54376480
Modulation of mammalian O6-alkylguanine-DNA alkyltransferase in vivo by O6-benzylguanine and its effect on the sensitivity of a human glioma tumor to 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea.Q55484775
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Improved plating efficiencies for human tumors cloned in capillary tubes versus Petri dishesQ69565957
Positive correlation between the extent of cell proliferation and the regulation of base excision repairQ71350045
DNA repairQ72883771
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Repair of DNA containing O6-alkylguanineQ28284603
Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agentsQ33689518
Apoptosis induced by anticancer drugsQ35233723
Protection against chloroethylnitrosourea cytotoxicity by eukaryotic 3-methyladenine DNA glycosylaseQ36730360
A reduced rate of bulky DNA adduct removal is coincident with differentiation of human neuroblastoma cells induced by nerve growth factorQ36845830
Medulloblastoma: tumor biological and clinical perspectivesQ37386386
The regulation of DNA repair during developmentQ37925497
DNA alkylation by the haloethylnitrosoureas: nature of modifications produced and their enzymatic repair or removalQ37984292
Isolation and purification of O6-alkylguanine-DNA alkyltransferase from human leukemic cells. Prevention of chloroethylnitrosourea-induced cross-links by purified enzymeQ39844025
Chemical mutagenesisQ40338278
Influence of proliferation on DNA repair rates in liverQ41172577
Effect of O6-methylguanine-DNA methyltransferase gene activity on repair in human cells transformed by a regulatable ada geneQ41750627
Efficacy of adjuvant chemotherapy for patients with poor-risk medulloblastoma: a preliminary reportQ44964244
Transfection and expression of human O6-methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: the role of MGMT in protection against the genotoxic effects of alkylating agentsQ46067039
The effects of O6-benzylguanine and hypoxia on the cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea in nitrosourea-resistant SF-763 cellsQ46280203
Treatment of subcutaneous and intracranial brain tumor xenografts with O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea.Q48379404
The MTT assay for chemosensitivity testing of human tumors of the central nervous system. Part I: Evaluation of test-specific variablesQ48483676
Increased repair of O6-alkylguanine DNA adducts in glioma-derived human cells resistant to the cytotoxic and cytogenetic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea.Q52834145
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)81-88
P577publication date1995-06-01
P1433published inMolecular CarcinogenesisQ15724597
P1476titleContribution of O6‐methylguanine‐DNA methyltransferase to resistance to 1,3‐(2‐chloroethyl)‐1‐nitrosourea in human brain tumor‐derived cell lines
P478volume13

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cites work (P2860)
Q54019386Altered nuclear localization of bax protein in BCNU-resistant glioma cells.
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Q33699997DNA ligase IV as a new molecular target for temozolomide
Q39701975DNA ligase IV is a potential molecular target in ACNU sensitivity
Q38840489Investigating a signature of temozolomide resistance in GBM cell lines using metabolomics
Q41905507Levetiracetam enhances p53-mediated MGMT inhibition and sensitizes glioblastoma cells to temozolomide
Q38350366MMR/c-Abl-dependent activation of ING2/p73alpha signaling regulates the cell death response to N-methyl-N'-nitro-N-nitrosoguanidine
Q36272990New delivery approaches for pediatric brain tumors
Q26853112O(6)-methylguanine-DNA methyltransferase in glioma therapy: promise and problems
Q40336092Synthesis and Antitumor Activity Evaluation of a Novel Combi-nitrosourea Prodrug: BGCNU.
Q36299167The prognostic value of MGMT promoter methylation in glioblastoma: A meta-analysis of clinical trials.

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