Transactivation of human endogenous retrovirus K (HERV-K) by KSHV promotes Kaposi's sarcoma development.

scientific article

Transactivation of human endogenous retrovirus K (HERV-K) by KSHV promotes Kaposi's sarcoma development. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/S41388-018-0282-4
P932PMC publication ID6195842
P698PubMed publication ID29743595

P50authorErik K FlemingtonQ62569596
P2093author name stringLu Dai
Luis Del Valle
Zhiqiang Qin
Augusto C Ochoa
Denise Whitby
Wendell Miley
P2860cites workInitial sequencing and analysis of the human genomeQ21045365
Reconstitution of an infectious human endogenous retrovirusQ21559512
Identification of an infectious progenitor for the multiple-copy HERV-K human endogenous retroelementsQ24676640
Identification of a Rev-related protein by analysis of spliced transcripts of the human endogenous retroviruses HTDV/HERV-KQ24678215
Human endogenous retrovirus K and cancer: Innocent bystander or tumorigenic accomplice?Q27010373
Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcomaQ28242984
Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomasQ28299069
Upregulation of xCT by KSHV-encoded microRNAs facilitates KSHV dissemination and persistence in an environment of oxidative stressQ28472699
Role of heme oxygenase-1 in the pathogenesis and tumorigenicity of Kaposi's sarcoma-associated herpesvirusQ28829309
Induction of hyaluronan production by oncogenic KSHV and the contribution to viral pathogenesis in AIDS patients.Q30357883
Identification of a major latent nuclear antigen, LNA-1, in the human herpesvirus 8 genomeQ30668836
cORF and RcRE, the Rev/Rex and RRE/RxRE homologues of the human endogenous retrovirus family HTDV/HERV-K.Q33292473
YY1 is autoregulated through its own DNA-binding sitesQ33497621
A viral gene that activates lytic cycle expression of Kaposi's sarcoma-associated herpesvirusQ33559699
Cancer angiogenesis induced by Kaposi sarcoma-associated herpesvirus is mediated by EZH2.Q33667093
p53 inhibition by the LANA protein of KSHV protects against cell deathQ33885642
Evidence for genomic rearrangements mediated by human endogenous retroviruses during primate evolutionQ34101407
Detection of antibodies to Kaposi's sarcoma-associated herpesvirus: a new approach using K8.1 ELISA and a newly developed recombinant LANA ELISA.Q34309014
Expression of human endogenous retrovirus K in melanomas and melanoma cell linesQ40421149
The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus modulates cellular gene expression and protects lymphoid cells from p16 INK4A-induced cell cycle arrestQ40496132
Epstein-Barr virus latent membrane protein LMP-2A is sufficient for transactivation of the human endogenous retrovirus HERV-K18 superantigenQ40541072
A novel gene from the human endogenous retrovirus K expressed in transformed cellsQ40725915
The human herpes virus 8-encoded viral FLICE inhibitory protein physically associates with and persistently activates the Ikappa B kinase complexQ40752466
Epstein-Barr virus transactivates the human endogenous retrovirus HERV-K18 that encodes a superantigenQ40773245
Epidemiology of Kaposi's sarcoma-associated herpesvirus in HIV-1-infected US persons in the era of combination antiretroviral therapy.Q41189777
Activation of NF-kappaB by the latent vFLIP gene of Kaposi's sarcoma-associated herpesvirus is required for the spindle shape of virus-infected endothelial cells and contributes to their proinflammatory phenotypeQ41494543
Expression of the human endogenous retrovirus (HERV) group HML-2/HERV-K does not depend on canonical promoter elements but is regulated by transcription factors Sp1 and Sp3.Q42707109
Expression of a human endogenous retrovirus, HERV-K, in the blood cells of leukemia patientsQ43882758
Cancer risk in people infected with human immunodeficiency virus in the United StatesQ45395561
Cutting edge: Epstein-Barr virus transactivates the HERV-K18 superantigen by docking to the human complement receptor 2 (CD21) on primary B cellsQ45413740
Molecular evidence of organ-related transmission of Kaposi sarcoma-associated herpesvirus or human herpesvirus-8 in transplant patientsQ73119354
Reactivation of and primary infection with human herpesvirus 8 among solid-organ transplant recipientsQ74054245
Expression of the human endogenous retrovirus-K transmembrane envelope, Rec and Np9 proteins in melanomas and melanoma cell linesQ83827058
Malignancy-related causes of death in human immunodeficiency virus-infected patients in the era of highly active antiretroviral therapyQ34332052
Kaposi's sarcoma-associated herpesvirus G-protein coupled receptor activates the canonical Wnt/β-catenin signaling pathwayQ35006465
Mechanisms of Kaposi's Sarcoma-Associated Herpesvirus Latency and ReactivationQ35010647
Recruitment of the de novo DNA methyltransferase Dnmt3a by Kaposi's sarcoma-associated herpesvirus LANAQ35080754
Direct activation of emmprin and associated pathogenesis by an oncogenic herpesvirusQ35453802
Antibodies against lytic and latent Kaposi's sarcoma-associated herpes virus antigens and lymphoma in the European EpiLymph case-control studyQ35623269
Immunotherapeutic potential of anti-human endogenous retrovirus-K envelope protein antibodies in targeting breast tumorsQ35742389
Kaposi's sarcoma-associated herpesvirus infection promotes invasion of primary human umbilical vein endothelial cells by inducing matrix metalloproteinasesQ35914351
A KSHV microRNA enhances viral latency and induces angiogenesis by targeting GRK2 to activate the CXCR2/AKT pathwayQ35983671
Fine-Tuning of the Kaposi's Sarcoma-Associated Herpesvirus Life Cycle in Neighboring Cells through the RTA-JAG1-Notch Pathway.Q36167973
Expression of human endogenous retrovirus type K (HML-2) is activated by the Tat protein of HIV-1.Q36171859
Targeting HGF/c-MET induces cell cycle arrest, DNA damage, and apoptosis for primary effusion lymphomaQ36406993
KSHV activation of VEGF secretion and invasion for endothelial cells is mediated through viral upregulation of emmprin-induced signal transductionQ36457808
Kaposi's sarcoma and its associated herpesvirusQ36487309
Kaposi's sarcoma-associated herpesvirus suppression of DUSP1 facilitates cellular pathogenesis following de novo infection.Q36506932
KSHV LANA inhibits TGF-beta signaling through epigenetic silencing of the TGF-beta type II receptorQ36591375
Endogenous retrovirus-K promoter: a landing strip for inflammatory transcription factors?Q36687211
Tumor cells expressing a retroviral envelope escape immune rejection in vivoQ36758070
Human endogenous retrovirus K (HML-2) elements in the plasma of people with lymphoma and breast cancerQ36898870
Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen regulates the KSHV epigenome by association with the histone demethylase KDM3A.Q36911800
HERV-K(HML-2), the Best Preserved Family of HERVs: Endogenization, Expression, and Implications in Health and DiseaseQ37186225
Keeping active endogenous retroviral-like elements in check: the epigenetic perspectiveQ37279907
Links between CD147 function, glycosylation, and caveolin-1.Q37496744
Human viral oncogenesis: a cancer hallmarks analysisQ37711147
Human herpes virus 8 in solid organ transplantationQ37938509
Human endogenous retroviruses and cancerQ38982814
Modulation of oncogenic signaling networks by Kaposi's sarcoma-associated herpesvirusQ39173806
The viral oncogene Np9 acts as a critical molecular switch for co-activating β-catenin, ERK, Akt and Notch1 and promoting the growth of human leukemia stem/progenitor cellsQ39212690
The NP9 protein encoded by the human endogenous retrovirus HERV-K(HML-2) negatively regulates gene activation of the Epstein-Barr virus nuclear antigen 2 (EBNA2).Q39516767
Characterization of the human endogenous retrovirus K Gag protein: identification of protease cleavage sites.Q39572030
Expression of HERV-K Correlates With Status of MEK–ERK and p16INK4A–CDK4 Pathways in Melanoma CellsQ39651144
Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus up-regulates transcription of human telomerase reverse transcriptase promoter through interaction with transcription factor Sp1.Q39992257
Long-term-infected telomerase-immortalized endothelial cells: a model for Kaposi's sarcoma-associated herpesvirus latency in vitro and in vivoQ40287215
Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA deliveryQ40390348
P407language of work or nameEnglishQ1860
P921main subjectKaposi's sarcomaQ725345
Human endogenous retrovirus KQ24975494
P577publication date2018-05-10
P1433published inOncogeneQ1568657
P1476titleTransactivation of human endogenous retrovirus K (HERV-K) by KSHV promotes Kaposi's sarcoma development.

Reverse relations

cites work (P2860)
Q91693298Endogenous Retroviruses Activity as a Molecular Signature of Neurodevelopmental Disorders
Q91779702Evolutionary Medicine of Retroviruses in the Human Genome
Q92501277Expression of PD-1 and PD-Ls in Kaposi's sarcoma and regulation by oncogenic herpesvirus lytic reactivation
Q102059098High levels of LINE-1 transposable elements expressed in Kaposi's sarcoma-associated herpesvirus-related primary effusion lymphoma
Q91604945Identification of new antiviral agents against Kaposi's sarcoma-associated herpesvirus (KSHV) by high-throughput drug screening reveals the role of histamine-related signaling in promoting viral lytic reactivation
Q60909604Transactivation of human endogenous retroviruses by tumor viruses and their functions in virus-associated malignancies
Q92821650Virus-induced transposable element expression up-regulation in human and mouse host cells

Search more.