Lung macrophage scavenger receptor SR-A6 (MARCO) is an adenovirus type-specific virus entry receptor.

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Lung macrophage scavenger receptor SR-A6 (MARCO) is an adenovirus type-specific virus entry receptor. is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PPAT.1006914
P8608Fatcat IDrelease_hfmh4oj5lfbb7ljoxe33ifaff4
P932PMC publication ID5862501
P698PubMed publication ID29522575

P50authorMaarit SuomalainenQ87656857
Silvio HemmiQ88011565
Mareike D MalerQ88011567
György FejerQ88011569
Justin FlattQ58862048
Nicole StichlingQ59558574
Martin PacesaQ59558580
Urs F GreberQ59829503
Tobias MayQ86221730
Markus SchmidQ87656855
Andreas PlückthunQ23057697
P2093author name stringMario Köster
Wolfgang Jungraithmayr
Marina A Freudenberg
P2860cites workAcute cytokine response to systemic adenoviral vectors in mice is mediated by dendritic cells and macrophagesQ45877053
Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control.Q47547452
Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors.Q48425484
Chemotactic antiviral cytokines promote infectious apical entry of human adenovirus into polarized epithelial cells.Q50064805
SR-A/MARCO-mediated ligand delivery enhances intracellular TLR and NLR function, but ligand scavenging from cell surface limits TLR4 response to pathogens.Q53450101
Stepwise dismantling of adenovirus 2 during entry into cellsQ64377608
Structure and chromosomal localization of the human and murine genes for the macrophage MARCO receptorQ22010053
HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackievirusesQ24312224
A simplified system for generating recombinant adenovirusesQ24682328
Development of Novel Adenoviral Vectors to Overcome Challenges Observed With HAdV-5-based ConstructsQ26782083
Tissue-resident macrophagesQ26991488
Endosome maturationQ26992067
Adenovirus vectors for gene therapy, vaccination and cancer gene therapyQ27001601
Key role of splenic myeloid DCs in the IFN-alphabeta response to adenoviruses in vivoQ27318346
Critical role for SV40 small-t antigen in human cell transformationQ40746221
New insights into the multidimensional concept of macrophage ontogeny, activation and function.Q40866271
Expression of macrophage MARCO receptor induces formation of dendritic plasma membrane processesQ40962080
Role of alveolar macrophages in rapid elimination of adenovirus vectors administered to the epithelial surface of the respiratory tractQ41088152
The macrophage paradoxQ41594710
Tracking viral genomes in host cells at single-molecule resolution.Q42261336
Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivoQ42579980
Nuclear localization of enhanced green fluorescent protein homomultimersQ42827185
Evaluation of accuracy and precision of adenovirus absorptivity at 260 nm under conditions of complete DNA disruptionQ44008421
Scavenger receptor A: a new route for adenovirus 5.Q44217236
The alphavbeta5 integrin of hematopoietic and nonhematopoietic cells is a transduction receptor of RGD-4C fiber-modified adenovirusesQ44552409
Toll-like receptor 9 triggers an innate immune response to helper-dependent adenoviral vectors.Q44592739
Drifting motions of the adenovirus receptor CAR and immobile integrins initiate virus uncoating and membrane lytic protein exposureQ45364122
Atomic Structure of Human Adenovirus by Cryo-EM Reveals Interactions Among Protein NetworksQ27664198
Fiji: an open-source platform for biological-image analysisQ27860912
Virus and Host Mechanics Support Membrane Penetration and Cell EntryQ28074634
Principles of Virus Uncoating: Cues and the Snooker BallQ28074854
Adenovirus membrane penetration: Tickling the tail of a sleeping dragonQ28084476
Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5Q28303765
A versatile viral system for expression and depletion of proteins in mammalian cellsQ28475909
MARCO is the major binding receptor for unopsonized particles and bacteria on human alveolar macrophagesQ28677922
Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachmentQ29615852
Virus entry by endocytosisQ29619724
Monocyte recruitment during infection and inflammationQ29620067
A direct and versatile assay measuring membrane penetration of adenovirus in single cellsQ30413406
MARCO, TLR2, and CD14 are required for macrophage cytokine responses to mycobacterial trehalose dimycolate and Mycobacterium tuberculosisQ33466750
Adenoviral vector immunity: its implications and circumvention strategiesQ33565630
Early steps of clathrin-mediated endocytosis involved in phagosomal escape of Fcgamma receptor-targeted adenovirusQ33782857
The macrophage receptor MARCO.Q33887468
Adenovirus protein VI mediates membrane disruption following capsid disassembly.Q33984709
Genetic variants in MARCO are associated with the susceptibility to pulmonary tuberculosis in Chinese Han populationQ34009065
Genetic Adaptation and Neandertal Admixture Shaped the Immune System of Human PopulationsQ34047556
Adenovirus infections in immunocompetent and immunocompromised patientsQ34057627
Crystal Structure of Human Adenovirus at 3.5 Å ResolutionQ34091180
Characterization of recombinant soluble macrophage scavenger receptor MARCO.Q34136893
The function of scavenger receptors expressed by macrophages and their role in the regulation of inflammationQ34184440
C911: A bench-level control for sequence specific siRNA off-target effectsQ34517408
Safety and Immunogenicity of Novel Adenovirus Type 26- and Modified Vaccinia Ankara-Vectored Ebola Vaccines: A Randomized Clinical TrialQ34522696
Genetic variants of MARCO are associated with susceptibility to pulmonary tuberculosis in a Gambian populationQ34686891
Vaccinia virus binds to the scavenger receptor MARCO on the surface of keratinocytes.Q34714569
Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14.Q34781681
Disruption of mouse CD46 causes an accelerated spontaneous acrosome reaction in spermQ34784569
IL-1α and complement cooperate in triggering local neutrophilic inflammation in response to adenovirus and eliminating virus-containing cellsQ35126751
The scavenger receptor MARCO modulates TLR-induced responses in dendritic cellsQ35218452
MARCO regulates early inflammatory responses against influenza: a useful macrophage function with adverse outcomeQ35684887
Avidity binding of human adenovirus serotypes 3 and 7 to the membrane cofactor CD46 triggers infectionQ35689715
Sensing infection by adenovirus: Toll-like receptor-independent viral DNA recognition signals activation of the interferon regulatory factor 3 master regulatorQ35785414
Identification of adenovirus serotype 5 hexon regions that interact with scavenger receptorsQ35826589
The role of the adenovirus protease on virus entry into cellsQ35847676
Macrophage Polarization in Virus-Host InteractionsQ35882034
The role of Kupffer cell activation and viral gene expression in early liver toxicity after infusion of recombinant adenovirus vectors.Q35899034
The role of scavenger receptors in pathogen recognition and innate immunityQ35916579
The innate immune response to adenovirus vectorsQ36026547
Macrophage receptors and immune recognitionQ36072472
Adenovirus serotype 26 utilizes CD46 as a primary cellular receptor and only transiently activates T lymphocytes following vaccination of rhesus monkeysQ36276518
Ad5:Ad48 hexon hypervariable region substitutions lead to toxicity and increased inflammatory responses following intravenous deliveryQ36445557
SR-A and SREC-I are Kupffer and endothelial cell receptors for helper-dependent adenoviral vectorsQ36740254
HSV-1 exploits the innate immune scavenger receptor MARCO to enhance epithelial adsorption and infection.Q36925941
Nontransformed, GM-CSF-dependent macrophage lines are a unique model to study tissue macrophage functions.Q36932454
Diminished Innate Antiviral Response to Adenovirus Vectors in cGAS/STING-Deficient Mice Minimally Impacts Adaptive ImmunityQ37002507
In vivo transduction of primitive mobilized hematopoietic stem cells after intravenous injection of integrating adenovirus vectorsQ37394036
Scavenger receptors: role in innate immunity and microbial pathogenesisQ37456941
Postentry neutralization of adenovirus type 5 by an antihexon antibodyQ37596703
Innate immunity to adenovirusQ37718852
The macrophage.Q37977397
Viral attachment strategies: the many faces of adenovirusesQ37996177
Adenovirus signalling in entryQ38053484
Uncoating of non-enveloped virusesQ38075203
Virus interactions with endocytic pathways in macrophages and dendritic cellsQ38119660
Scavenger receptors in homeostasis and immunityQ38127564
Adenoviruses types, cell receptors and local innate cytokines in adenovirus infectionQ38152792
Human adenovirus: Viral pathogen with increasing importanceQ38200093
Human alveolar epithelial cells expressing tight junctions to model the air-blood barrierQ38785626
Immunity duration of a recombinant adenovirus type-5 vector-based Ebola vaccine and a homologous prime-boost immunisation in healthy adults in China: final report of a randomised, double-blind, placebo-controlled, phase 1 trialQ39065629
Co-option of Membrane Wounding Enables Virus Penetration into Cells.Q39193544
Kinesin-1-mediated capsid disassembly and disruption of the nuclear pore complex promote virus infectionQ39472506
The coxsackievirus-adenovirus receptor protein can function as a cellular attachment protein for adenovirus serotypes from subgroups A, C, D, E, and FQ39581053
Internalization of adenovirus by alveolar macrophages initiates early proinflammatory signaling during acute respiratory tract infectionQ39593402
Functional and selective targeting of adenovirus to high-affinity Fcgamma receptor I-positive cells by using a bispecific hybrid adapterQ39601286
Functional genetic and biophysical analyses of membrane disruption by human adenovirusQ39611726
Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligandsQ39791660
Cryo-electron microscopy structure of an adenovirus-integrin complex indicates conformational changes in both penton base and integrinQ39804477
Species B adenovirus serotypes 3, 7, 11 and 35 share similar binding sites on the membrane cofactor protein CD46 receptorQ40065588
Key Role of the Scavenger Receptor MARCO in Mediating Adenovirus Infection and Subsequent Innate Responses of MacrophagesQ40098925
Transcriptional control of SV40 T-antigen expression allows a complete reversion of immortalizationQ40249879
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesCellProfilerQ5058134
P433issue3
P921main subjectmacrophageQ184204
AdenoviridaeQ193447
P304page(s)e1006914
P577publication date2018-03-09
P1433published inPLOS PathogensQ283209
P1476titleLung macrophage scavenger receptor SR-A6 (MARCO) is an adenovirus type-specific virus entry receptor
P478volume14

Reverse relations

cites work (P2860)
Q90281973Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease
Q64096999Adenovirus flow in host cell networks
Q93004236Antibody and DNA sensing pathways converge to activate the inflammasome during primary human macrophage infection
Q64250440Class A Scavenger Receptors Are Used by Frog Virus 3 During Its Cellular Entry
Q52579616Concepts in Light Microscopy of Viruses.
Q55467684Designer Oncolytic Adenovirus: Coming of Age.
Q52333281Imaging, Tracking and Computational Analyses of Virus Entry and Egress with the Cytoskeleton.
Q59354245Tropism and transduction of oncolytic adenovirus 5 vectors in cancer therapy: Focus on fiber chimerism and mosaicism, hexon and pIX
Q58546247αvβ3 Integrin is Required for Efficient Infection of Epithelial Cells with Human Adenovirus Type 26

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