Forkhead box C2

mammalian protein found in Homo sapiens

Forkhead box C2 is …
instance of (P31):
proteinQ8054

External links are
P705Ensembl protein IDENSP00000497759
P638PDB structure ID1D5V
P637RefSeq protein IDNP_005242
P352UniProt protein IDQ99958

P682biological processcell population proliferationQ189101
cell differentiationQ210861
Notch signaling pathwayQ904082
ossificationQ1121544
kidney developmentQ2336077
somitogenesisQ3489847
lymphangiogenesisQ6708231
response to hormoneQ14599419
negative regulation of transcription by RNA polymerase IIQ14633878
regulation of transcription, DNA-templatedQ14633883
multicellular organism developmentQ14645705
insulin receptor signaling pathwayQ14758913
transcription, DNA-templatedQ14763010
positive regulation of transcription, DNA-templatedQ14818066
positive regulation of transcription by RNA polymerase IIQ14818068
heart developmentQ14819288
ureteric bud developmentQ14819652
camera-type eye developmentQ14820061
heart morphogenesisQ14852031
regulation of transcription by RNA polymerase IIQ14852032
ventricular cardiac muscle tissue morphogenesisQ14852037
blood vessel developmentQ14859587
blood vessel remodelingQ14859590
positive regulation of endothelial cell migrationQ14859610
branching involved in blood vessel morphogenesisQ14859907
metanephros developmentQ14859909
skeletal system developmentQ14860466
negative regulation of cold-induced thermogenesisQ54810623
anatomical structure morphogenesisQ14864210
transcription by RNA polymerase IIQ14864650
collagen fibril organizationQ14864949
glomerular endothelium developmentQ14873713
paraxial mesoderm formationQ14882514
vascular endothelial growth factor receptor signaling pathwayQ14885636
mesoderm developmentQ14885836
embryonic skeletal system morphogenesisQ14886895
cardiac muscle cell proliferationQ14889336
artery morphogenesisQ14890445
embryonic viscerocranium morphogenesisQ14897665
embryonic heart tube developmentQ14902766
embryonic cranial skeleton morphogenesisQ14903355
neural crest cell developmentQ14904955
positive regulation of cell adhesion mediated by integrinQ14905599
positive regulation of vascular wound healingQ14905600
regulation of organ growthQ14905601
paraxial mesodermal cell fate commitmentQ14905602
glomerular visceral epithelial cell differentiationQ14905603
glomerular mesangial cell developmentQ14905604
positive regulation of cell migration involved in sprouting angiogenesisQ14905605
lymph vessel developmentQ14905608
negative regulation of apoptotic process involved in outflow tract morphogenesisQ14905610
P681cell componentnucleusQ40260
nucleoplasmQ14817956
nuclear bodyQ14817965
P702encoded byFOXC2Q14905606
P703found in taxonHomo sapiensQ15978631
P527has part(s)Fork head domain conserved site1Q24725846
Fork head domain conserved site 2Q24738870
Fork head domainQ24773206
P680molecular functionprotein bindingQ167149
DNA bindingQ14633858
identical protein bindingQ14762994
DNA-binding transcription activator activity, RNA polymerase II-specificQ14817973
DNA-binding transcription factor activityQ14817979
sequence-specific DNA bindingQ14818107
transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingQ14819273
promoter-specific chromatin bindingQ22312996
DNA-binding transcription factor activity, RNA polymerase II-specificQ14864645
RNA polymerase II transcription regulatory region sequence-specific DNA bindingQ14864823
chromatin DNA bindingQ14880772
RNA polymerase II cis-regulatory region sequence-specific DNA bindingQ14885806
P361part ofWinged helix-like DNA-binding domain superfamilyQ41797502
winged helix DNA-binding domain superfamilyQ41797505
Fork head domain, protein familyQ83140978
Fork head domain conserved site 2, protein familyQ95352040
Fork head domain conserved site1, protein familyQ95354114

Reverse relations

main subject (P921)
Q24301349Analysis of the phenotypic abnormalities in lymphoedema-distichiasis syndrome in 74 patients with FOXC2 mutations or linkage to 16q24
Q24336043Clustered arrangement of winged helix genes fkh-6 and MFH-1: possible implications for mesoderm development
Q28215944FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance
Q24303512Foxc2 is a common mediator of insulin and transforming growth factor beta signaling to regulate plasminogen activator inhibitor type I gene expression
Q24298680Identification of de novo mutations and rare variants in hypoplastic left heart syndrome
Q24329271Isolation of the mouse (MFH-1) and human (FKHL 14) mesenchyme fork head-1 genes reveals conservation of their gene and protein structures
Q24313055The establishment of a predictive mutational model of the forkhead domain through the analyses of FOXC2 missense mutations identified in patients with hereditary lymphedema with distichiasis
Q24291699The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis
Q24303837Transcription Elongation Regulator 1 Is a Co-integrator of the Cell Fate Determination Factor Dachshund Homolog 1

Q14905606FOXC2encodesP688

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