Human embryonic stem cells rapidly take up and then clear exogenous human and animal prions in vitro.

scientific article

Human embryonic stem cells rapidly take up and then clear exogenous human and animal prions in vitro. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/PATH.2832
P698PubMed publication ID21341268
P5875ResearchGate publication ID230246406

P50authorPaul De SousaQ38360854
Stephen PellsQ42802376
Mark W HeadQ55300123
Jean C MansonQ56449149
Zuzana KrejciovaQ117221975
Enrico CancellottiQ117221979
James IronsideQ29643044
P2093author name stringMatthew Bishop
G Robin Barclay
Kay Samuel
Marc L Turner
Paz Freile
P2860cites workPrion-like disorders: blurring the divide between transmissibility and infectivityQ39863503
Variations in humanized and defined culture conditions supporting derivation of new human embryonic stem cell linesQ40188775
Iatrogenic Creutzfeldt-Jakob disease: the waning of an era.Q40305663
Clinically failed eggs as a source of normal human embryo stem cellsQ42811221
Variant CJD infection in the spleen of a neurologically asymptomatic UK adult patient with haemophiliaQ43195687
Predicting susceptibility and incubation time of human-to-human transmission of vCJD.Q43220422
Transmissions to mice indicate that 'new variant' CJD is caused by the BSE agentQ44592404
Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potentialQ47985026
Clinical presentation and pre-mortem diagnosis of variant Creutzfeldt-Jakob disease associated with blood transfusion: a case report.Q48340913
Insoluble aggregates and protease-resistant conformers of prion protein in uninfected human brains.Q48417052
Neural stem cell model for prion propagationQ48513161
Possible transmission of variant Creutzfeldt-Jakob disease by blood transfusion.Q51037857
The expression of prion protein (PrP(C)) in the megakaryocyte lineage.Q54242297
Prion protein is expressed on long-term repopulating hematopoietic stem cells and is important for their self-renewalQ24541459
A novel human disease with abnormal prion protein sensitive to proteaseQ24648865
Shattuck lecture--neurodegenerative diseases and prionsQ28189500
Mice devoid of PrP are resistant to scrapieQ28249108
A general model of prion strains and their pathogenicityQ28256770
The expanding universe of prion diseasesQ33239695
PRNP variation in UK sporadic and variant Creutzfeldt Jakob disease highlights genetic risk factors and a novel non-synonymous polymorphismQ33520832
Iatrogenic Creutzfeldt-Jakob disease at the millennium.Q33924749
Kuru in the 21st century--an acquired human prion disease with very long incubation periodsQ33997105
Feeder-free growth of undifferentiated human embryonic stem cellsQ34093315
Preclinical vCJD after blood transfusion in a PRNP codon 129 heterozygous patientQ34339769
A new variant of Creutzfeldt-Jakob disease in the UK.Q34374893
Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD.Q34403513
High titers of transmissible spongiform encephalopathy infectivity associated with extremely low levels of PrPSc in vivo.Q34699610
Prion infection of mouse neurospheresQ34944193
Detection of type 1 prion protein in variant Creutzfeldt-Jakob diseaseQ35070708
Accumulation of prion protein in the brain that is not associated with transmissible diseaseQ35721757
PrPc does not mediate internalization of PrPSc but is required at an early stage for de novo prion infection of Rov cellsQ36099038
Diagnostic approaches for viruses and prions in stem cell banksQ36354421
Creutzfeldt-Jakob disease and blood transfusion: results of the UK Transfusion Medicine Epidemiological Review studyQ36588347
Prions and their partners in crimeQ36628157
Halting the spread of human prion disease--exceptional measures for an exceptional problemQ36836191
Insights into prion strains and neurotoxicityQ36856446
Acute cellular uptake of abnormal prion protein is cell type and scrapie-strain independent.Q37039973
An update on the assessment and management of the risk of transmission of variant Creutzfeldt-Jakob disease by blood and plasma productsQ37307945
Incidence and spectrum of sporadic Creutzfeldt-Jakob disease variants with mixed phenotype and co-occurrence of PrPSc types: an updated classificationQ37411403
The genetics of prion diseasesQ37705846
P433issue5
P921main subjecthuman embryonic stem cellQ59626782
prion protein familyQ24724413
P304page(s)635-645
P577publication date2011-02-21
P1433published inJournal of PathologyQ400296
P1476titleHuman embryonic stem cells rapidly take up and then clear exogenous human and animal prions in vitro.
P478volume223

Reverse relations

cites work (P2860)
Q37252741A specific population of abnormal prion protein aggregates is preferentially taken up by cells and disaggregated in a strain-dependent manner
Q93005212All the Same? The Secret Life of Prion Strains within Their Target Cells
Q38075119Human prion diseases: molecular, cellular and population biology
Q46174770Human stem cell-derived astrocytes replicate human prions in a PRNP genotype-dependent manner
Q37415409Human tonsil-derived follicular dendritic-like cells are refractory to human prion infection in vitro and traffic disease-associated prion protein to lysosomes
Q48239641Quality Assured Characterization of Stem Cells for Safety in Banking for Clinical Application
Q64463950Renewed assessment of the risk of emergent advanced cell therapies to transmit neuroproteinopathies
Q34391242The prion protein family: a view from the placenta
Q34646980Uptake and degradation of protease-sensitive and -resistant forms of abnormal human prion protein aggregates by human astrocytes

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