Impaired miR-146a expression links subclinical inflammation and insulin resistance in Type 2 diabetes.

scientific article

Impaired miR-146a expression links subclinical inflammation and insulin resistance in Type 2 diabetes. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S11010-011-0727-3
P698PubMed publication ID21249428
P5875ResearchGate publication ID49769175

P50authorParamasivam PrabuQ59705203
P2093author name stringV Mohan
M Balasubramanyam
K Gokulakrishnan
S Aravind
H Ranjani
C Sathishkumar
P2860cites workSuppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathwaysQ40485152
Loss of mir-146a function in hormone-refractory prostate cancerQ42055882
Oxidative DNA damage and augmentation of poly(ADP-ribose) polymerase/nuclear factor-kappa B signaling in patients with type 2 diabetes and microangiopathyQ42513483
Tumor necrosis factor-alpha induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt substrate 160 phosphorylationQ43699235
Subclinical inflammation/oxidation as revealed by altered gene expression profiles in subjects with impaired glucose tolerance and Type 2 diabetes patientsQ46177953
Suppressor of cytokine signalling-3 expression inhibits cytokine-mediated destruction of primary mouse and rat pancreatic islets and delays allograft rejectionQ46467772
Insufficient glycemic control increases nuclear factor-kappa B binding activity in peripheral blood mononuclear cells isolated from patients with type 1 diabetesQ47693425
Is type II diabetes mellitus a disease of the innate immune system?Q48364597
Relationship between serum tumor necrosis factor-alpha and insulin resistance in obese men with Type 2 diabetes mellitus.Q51549607
MicroRNA-146a feedback inhibits RIG-I-dependent Type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2.Q54733079
Biomarkers in osteoarthritisQ58210782
Circulating levels of TNF-alpha and IL-6-relation to truncal fat mass and muscle mass in healthy elderly individuals and in patients with type-2 diabetesQ59326276
Kinetics of calcium transport across the lymphocyte plasma membraneQ70474025
Visfatin, TNF-alpha and IL-6 mRNA expression is increased in mononuclear cells from type 2 diabetic womenQ81479451
TRAF6 knockdown promotes survival and inhibits inflammatory response to lipopolysaccharides in rat primary renal proximal tubule cellsQ82805396
Suppressor of cytokine Signaling-3 inhibits interleukin-1 signaling by targeting the TRAF-6/TAK1 complexQ82858440
MicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteinsQ83586463
Inflammation and insulin resistanceQ22241893
Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancersQ24625794
The microRNA signature in response to insulin reveals its implication in the transcriptional action of insulin in human skeletal muscle and the role of a sterol regulatory element-binding protein-1c/myocyte enhancer factor 2C pathwayQ24648295
NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responsesQ24670080
MicroRNAs: genomics, biogenesis, mechanism, and functionQ27861070
Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of IkkbetaQ28188643
Serum levels of interleukin 6, C-reactive protein, vascular cell adhesion molecule 1, and monocyte chemotactic protein 1 in relation to insulin resistance and glucose intolerance--the Chennai Urban Rural Epidemiology Study (CURES)Q28200186
Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanismsQ28586863
Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultationQ29547453
Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaBQ29619314
Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistanceQ33941406
Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinomaQ34778280
The association between innate immunity gene (IRAK1) and C-reactive protein in the Diabetes Heart StudyQ36015656
Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patientsQ36955334
Inflammation and progressive nephropathy in type 1 diabetes in the diabetes control and complications trialQ36975713
MicroRNAs: novel regulators in skin inflammationQ37141220
microRNAs and the immune responseQ37178538
SNPs in human miRNA genes affect biogenesis and functionQ37344542
The expression of TNF alpha by human muscle. Relationship to insulin resistanceQ37352139
Expression of microRNA-146 in rheumatoid arthritis synovial tissueQ37359799
Meta-regulation: microRNA regulation of glucose and lipid metabolismQ37607525
Role of NF-kappa B in the pathogenesis of diabetes and its associated complicationsQ37611364
IRAK1 serves as a novel regulator essential for lipopolysaccharide-induced interleukin-10 gene expressionQ38335828
Effects of initiating insulin and metformin on glycemic control and inflammatory biomarkers among patients with type 2 diabetes: the LANCET randomized trialQ38378882
Selective DNA binding and association with the CREB binding protein coactivator contribute to differential activation of alpha/beta interferon genes by interferon regulatory factors 3 and 7.Q39455009
The Chennai Urban Rural Epidemiology Study (CURES)--study design and methodology (urban component) (CURES-I).Q39673252
Suppressors of cytokine signaling abrogate diabetic nephropathyQ39735007
Association of high sensitivity C-reactive protein (hsCRP) and tumour necrosis factor-alpha (TNF-alpha) with carotid intimal medial thickness in subjects with different grades of glucose intolerance--the Chennai Urban Rural Epidemiology Study (CURESQ39838141
P433issue1-2
P921main subjectinsulin resistanceQ1053470
type 2 diabetesQ3025883
inflammationQ101991
preproinsulinQ7240673
P304page(s)197-205
P577publication date2011-01-20
P1433published inMolecular and Cellular BiochemistryQ1573176
P1476titleImpaired miR-146a expression links subclinical inflammation and insulin resistance in Type 2 diabetes
P478volume351

Reverse relations

cites work (P2860)
Q46922229(-)-Epigallocatechin-3-gallate alleviates spatial memory impairment in APP/PS1 mice by restoring IRS-1 signaling defects in the hippocampus
Q37728970A Systematic Study of Dysregulated MicroRNA in Type 2 Diabetes Mellitus
Q42825832Accelerated fat cell aging links oxidative stress and insulin resistance in adipocytes
Q42362062Acute strength training promotes responses in whole blood circulating levels of miR-146a among older adults with type 2 diabetes mellitus.
Q36811697Affection of single-nucleotide polymorphisms in miR-27a, miR-124a, and miR-146a on susceptibility to type 2 diabetes mellitus in Chinese Han people
Q35895767Amelioration of glucolipotoxicity-induced endoplasmic reticulum stress by a "chemical chaperone" in human THP-1 monocytes
Q46792665Analysis of circulating microRNAs that are specifically increased in hyperlipidemic and/or hyperglycemic sera
Q42371220Anti-Inflammatory Role of MicroRNA-146a in the Pathogenesis of Diabetic Nephropathy
Q64232914Anti-inflammatory microRNA-146a protects mice from diet-induced metabolic disease
Q53281104Association of MiR-146a Expression and Type 2 Diabetes Mellitus: A Meta-Analysis.
Q36275002Association study of polymorphisms in miRNAs with T2DM in Chinese population
Q37389836Atypical Diabetic Foot Ulcer Keratinocyte Protein Signaling Correlates with Impaired Wound Healing.
Q37436828Augmentation of histone deacetylase 3 (HDAC3) epigenetic signature at the interface of proinflammation and insulin resistance in patients with type 2 diabetes
Q92855414Can Epigenetics of Endothelial Dysfunction Represent the Key to Precision Medicine in Type 2 Diabetes Mellitus?
Q40616882Circulating cell-free mature microRNAs and their target gene prediction in bovine metritis
Q36955787Circulating inflamma-miRs in aging and age-related diseases
Q39141563Circulating microRNAs and diabetes mellitus: a novel tool for disease prediction, diagnosis, and staging?
Q38544077Circulating microRNAs and diabetes: potential applications in medical practice.
Q53807960Circulating microRNAs in Diabetes Progression: Discovery, Validation, and Research Translation.
Q34179239Circulating microRNAs in patients with non-alcoholic fatty liver disease
Q58923865Common polymorphisms in MIR146a, MIR128a and MIR27a genes contribute to neuropathy susceptibility in type 2 diabetes
Q38760874Contribution of MicroRNAs to autoimmune diseases
Q34690982Decreased serum level of miR-146a as sign of chronic inflammation in type 2 diabetic patients
Q53643581Deregulation of NF-кB-miR-146a negative feedback loop may be involved in the pathogenesis of diabetic neuropathy.
Q38598866Diabetes and ageing-induced vascular inflammation
Q38858690E-selectin-targeting delivery of microRNAs by microparticles ameliorates endothelial inflammation and atherosclerosis.
Q89999365Epigenetic disturbances in obesity and diabetes: Epidemiological and functional insights
Q35645997Epigenetic mechanisms of endothelial dysfunction in type 2 diabetes
Q36242179Epithelial cell-derived micro RNA-146a generates interleukin-10-producing monocytes to inhibit nasal allergy
Q53520277Exosomal MicroRNA-15a Transfer from the Pancreas Augments Diabetic Complications by Inducing Oxidative Stress.
Q57300009Exosomes Derived From Mesenchymal Stromal Cells Pretreated With Advanced Glycation End Product-Bovine Serum Albumin Inhibit Calcification of Vascular Smooth Muscle Cells
Q36001906Exposure and fetal growth-associated miRNA alterations in the human placenta
Q36806427Genetic association of miRNA-146a with systemic lupus erythematosus in Europeans through decreased expression of the gene.
Q36942373High glucose concentration induces endothelial cell proliferation by regulating cyclin-D2-related miR-98.
Q34541913High-fructose diet is as detrimental as high-fat diet in the induction of insulin resistance and diabetes mediated by hepatic/pancreatic endoplasmic reticulum (ER) stress.
Q46773455Identification of microRNA biomarkers in type 2 diabetes: a meta-analysis of controlled profiling studies
Q95267574Impact of Low Interferon-γ and IL-10 Levels on TNF-α and IL-6 Production by PHA-Induced PBMCs in Type 2 Diabetes Mellitus
Q92820179Impact of mesenchymal stem cell senescence on inflammaging
Q51377185Improvement in glucose tolerance and insulin sensitivity by probiotic strains of Indian gut origin in high-fat diet-fed C57BL/6J mice.
Q40158529Increased circulatory levels of lipopolysaccharide (LPS) and zonulin signify novel biomarkers of proinflammation in patients with type 2 diabetes
Q28536498Increased microRNA-146a levels in plasma of patients with newly diagnosed type 2 diabetes mellitus
Q91302959Interplay between early-life malnutrition, epigenetic modulation of the immune function and liver diseases
Q39127898Interplay between miRNAs and human diseases
Q36205231Metabolic memory and chronic diabetes complications: potential role for epigenetic mechanisms
Q34233659MiR-133a in human circulating monocytes: a potential biomarker associated with postmenopausal osteoporosis
Q27307894MiR-155 Enhances Insulin Sensitivity by Coordinated Regulation of Multiple Genes in Mice
Q53842061MiR-26b modulates insulin sensitivity in adipocytes by interrupting the PTEN/PI3K/AKT pathway.
Q92537678MiRNAs Regulating Insulin Sensitivity Are Dysregulated in Polycystic Ovary Syndrome (PCOS) Ovaries and Are Associated With Markers of Inflammation and Insulin Sensitivity
Q33654397MicroRNA Expression Varies according to Glucose Tolerance, Measurement Platform, and Biological Source
Q64074554MicroRNA Post-transcriptional Regulation of the NLRP3 Inflammasome in Immunopathologies
Q58923883MicroRNA genetic variations: association with type 2 diabetes
Q36890424MicroRNA in cardiovascular calcification: focus on targets and extracellular vesicle delivery mechanisms.
Q38103446MicroRNA in immunity and autoimmunity
Q35565357MicroRNA signatures differentiate preserved from reduced ejection fraction heart failure
Q34266384MicroRNA-146a decreases high glucose/thrombin-induced endothelial inflammation by inhibiting NAPDH oxidase 4 expression
Q55279635MicroRNA-146a: A Comprehensive Indicator of Inflammation and Oxidative Stress Status Induced in the Brain of Chronic T2DM Rats.
Q55089831MicroRNA-146b-3p regulates the development and progression of cerebral infarction with diabetes through RAF1/P38MAPK/COX-2 signaling pathway.
Q27025580MicroRNAs Related to Polycystic Ovary Syndrome (PCOS)
Q26852909MicroRNAs: new insights into chronic childhood diseases
Q38780771Microparticles of healthy origins improve endothelial progenitor cell dysfunction via microRNA transfer in an atherosclerotic hamster model.
Q33911774Mother's Pre-pregnancy BMI and Placental Candidate miRNAs: Findings from the ENVIRONAGE Birth Cohort.
Q38561971Noncoding RNAs and chronic inflammation: Micro-managing the fire within.
Q60475996Postprandial inflammation is not associated with endoplasmic reticulum stress in peripheral blood mononuclear cells from healthy lean men
Q38944060Recent progress toward the use of circulating microRNAs as clinical biomarkers
Q36209324Regulation of Macrophage, Dendritic Cell, and Microglial Phenotype and Function by the SOCS Proteins.
Q33815663Regulation of retinal inflammation by rhythmic expression of MiR-146a in diabetic retina
Q38230799Relevance of microRNA in metabolic diseases.
Q38899151SEAP activity serves for demonstrating ER stress induction by glucolipotoxicity as well as testing ER stress inhibitory potential of therapeutic agents
Q37594083SIRT4 overexpression protects against diabetic nephropathy by inhibiting podocyte apoptosis
Q92645690Sequence variation in microRNA-34a is associated with diabetes mellitus susceptibility in a southwest Chinese Han population
Q93018504Significance of circulating microRNAs in diabetes mellitus type 2 and platelet reactivity: bioinformatic analysis and review
Q50796757Silencing miR-146a influences B cells and ameliorates experimental autoimmune myasthenia gravis.
Q36485126Socs1 and Socs3 degrades Traf6 via polyubiquitination in LPS-induced acute necrotizing pancreatitis
Q36466672Study on inflammation-related genes and microRNAs, with special emphasis on the vascular repair factor HGF and miR-574-3p, in monocytes and serum of patients with T2D.
Q38177673Suppressors of cytokine signaling (SOCS) and type 2 diabetes
Q52661592TRAF molecules in inflammation and inflammatory diseases.
Q26827627The Role of MicroRNAs in Diabetic Complications-Special Emphasis on Wound Healing
Q90437527The association of two common polymorphisms in miRNAs with diabetes mellitus: A meta-analysis
Q39152911The impact of chronic hepatitis C infection on cholesterol metabolism in PBMCs is associated with microRNA-146a expression
Q37512125The role of miR-146a in dorsal root ganglia neurons of experimental diabetic peripheral neuropathy
Q48147993The rs2910164 variant is associated with reduced miR-146a expression but not cytokine levels in patients with type 2 diabetes
Q35665925Type 2 Diabetes Monocyte MicroRNA and mRNA Expression: Dyslipidemia Associates with Increased Differentiation-Related Genes but Not Inflammatory Activation
Q38194186Type 2 diabetes mellitus-related genetic polymorphisms in microRNAs and microRNA target sites.
Q46004196Upregulation of microRNA-146a was not accompanied by downregulation of pro-inflammatory markers in diabetic kidney.
Q54267584Whole transcriptome analysis reveals differential gene expression profile reflecting macrophage polarization in response to influenza A H5N1 virus infection.
Q38784593miR-146a Attenuates Inflammatory Pathways Mediated by TLR4/NF-κB and TNFα to Protect Primary Human Retinal Microvascular Endothelial Cells Grown in High Glucose
Q93064272miR-146a Deficiency Accelerates Hepatic Inflammation Without Influencing Diet-induced Obesity in Mice
Q38916732miR-146a mediates inflammatory changes and fibrosis in the heart in diabetes.
Q89997759miR-146a mediates thymosin β4 induced neurovascular remodeling of diabetic peripheral neuropathy in type-II diabetic mice
Q53339809miR-146a suppresses STAT3/VEGF pathways and reduces apoptosis through IL-6 signaling in primary human retinal microvascular endothelial cells in high glucose conditions.
Q43438635miR-210 over-expression enhances mesenchymal stem cell survival in an oxidative stress environment through antioxidation and c-Met pathway activation
Q38600595miRNAs: early prognostic biomarkers for Type 2 diabetes mellitus?
Q48562097microRNA in Human Reproduction
Q34245279microRNA regulation of inflammatory responses

Search more.