MYH biallelic mutation can inactivate the two genetic pathways of colorectal cancer by APC or MLH1 transversions.

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MYH biallelic mutation can inactivate the two genetic pathways of colorectal cancer by APC or MLH1 transversions. is …
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scholarly articleQ13442814

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P356DOI10.1007/S10689-010-9367-0
P698PubMed publication ID20640893
P5875ResearchGate publication ID45272978

P50authorWalter BodmerQ7964332
Carolina BonillaQ55174109
Jean-François FléjouQ72536365
P2093author name stringFlorence Coulet
Florent Soubrier
Yann Parc
Najat Mourra
Emmanuel Tiret
Jérémie H Lefevre
Chrystelle Colas
P2860cites workHuman MutY homolog, a DNA glycosylase involved in base excision repair, physically and functionally interacts with mismatch repair proteins human MutS homolog 2/human MutS homolog 6Q24292187
Carcinogenesis in MYH-associated polyposis follows a distinct genetic pathwayQ28186388
BRAF mutation is frequently present in sporadic colorectal cancer with methylated hMLH1, but not in hereditary nonpolyposis colorectal cancerQ28239788
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinomaQ29615026
Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell linesQ29620526
A founding locus within the RET proto-oncogene may account for a large proportion of apparently sporadic Hirschsprung disease and a subset of cases of sporadic medullary thyroid carcinomaQ34355050
Immunohistochemistry for MSH2 and MHL1: a method for identifying mismatch repair deficient colorectal cancerQ35399001
BRAF screening as a low-cost effective strategy for simplifying HNPCC genetic testingQ35446668
The interacting pathways for prevention and repair of oxidative DNA damageQ35592880
Prognostic significance of microsatellite instability determined by immunohistochemical staining of MSH2 and MLH1 in sporadic T3N0M0 colon cancerQ35596287
The role of MYH and microsatellite instability in the development of sporadic colorectal cancerQ36611848
Inherited variants of MYH associated with somatic G:C-->T:A mutations in colorectal tumorsQ43871566
The mammalian mismatch repair pathway removes DNA 8-oxodGMP incorporated from the oxidized dNTP poolQ44025676
Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instabilityQ47704165
Gene conversion is a frequent mechanism of inactivation of the wild-type allele in cancers from MLH1/MSH2 deletion carriers.Q53350238
Implication of MYH in colorectal polyposis.Q54451550
Aberrant splicing in MLH1 and MSH2 due to exonic and intronic variants.Q54627316
No evidence for dual role of loss of heterozygosity in hereditary non-polyposis colorectal cancerQ57567633
Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancerQ57568035
Efficiency of the revised Bethesda guidelines (2003) for the detection of mutations in mismatch repair genes in Austrian HNPCC patientsQ81312576
Deletions account for 17% of pathogenic germline alterations in MLH1 and MSH2 in hereditary nonpolyposis colorectal cancer (HNPCC) familiesQ81826211
P433issue4
P921main subjectcolorectal cancerQ188874
P304page(s)589-594
P577publication date2010-12-01
P1433published inFamilial CancerQ15761917
P1476titleMYH biallelic mutation can inactivate the two genetic pathways of colorectal cancer by APC or MLH1 transversions.
P478volume9