Flagellin contamination of recombinant heat shock protein 70 is responsible for its activity on T cells.

scientific article

Flagellin contamination of recombinant heat shock protein 70 is responsible for its activity on T cells. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M606802200
P698PubMed publication ID17178717

P2093author name stringZhiyong Ye
Yunn-Hwen Gan
P2860cites workCytokine function of heat shock proteinsQ35682849
Natural endogenous adjuvants.Q35988793
In vivo cytotoxic T lymphocyte elicitation by mycobacterial heat shock protein 70 fusion proteins maps to a discrete domain and is CD4(+) T cell independentQ36375719
Dendritic cell stimulation by mycobacterial Hsp70 is mediated through CCR5.Q40217771
Mycobacterium tuberculosis heat shock proteins use diverse Toll-like receptor pathways to activate pro-inflammatory signalsQ40439026
Heat shock protein 60: specific binding of lipopolysaccharide.Q40468305
Helicobacter pylori Heat Shock Protein 60 Mediates Interleukin-6 Production by Macrophages via a Toll-like Receptor (TLR)-2-, TLR-4-, and Myeloid Differentiation Factor 88-independent MechanismQ40624008
Recombinant human heat shock protein 60 does not induce the release of tumor necrosis factor alpha from murine macrophagesQ40657222
Integrin-nucleated Toll-like receptor (TLR) dimerization reveals subcellular targeting of TLRs and distinct mechanisms of TLR4 activation and signalingQ40686330
The adjuvant effects of Mycobacterium tuberculosis heat shock protein 70 result from the rapid and prolonged activation of antigen-specific CD8+ T cells in vivoQ40691486
Endotoxin contamination in recombinant human heat shock protein 70 (Hsp70) preparation is responsible for the induction of tumor necrosis factor alpha release by murine macrophagesQ40693930
Stimulation of Th1-polarizing cytokines, C-C chemokines, maturation of dendritic cells, and adjuvant function by the peptide binding fragment of heat shock protein 70.Q40708925
Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigensQ42261747
Heat shock protein 60 enhances CD4+ CD25+ regulatory T cell function via innate TLR2 signalingQ42416289
T cells respond to heat shock protein 60 via TLR2: activation of adhesion and inhibition of chemokine receptors.Q51835996
Direct stimulation of human T cells via TLR5 and TLR7/8: flagellin and R-848 up-regulate proliferation and IFN-gamma production by memory CD4+ T cells.Q51990275
Human CD4+ T Cells Express TLR5 and Its Ligand Flagellin Enhances the Suppressive Capacity and Expression of FOXP3 in CD4+CD25+ T Regulatory CellsQ57447880
Lipopolysaccharide-free heat shock protein 60 activates T cellsQ24304283
Heat shock protein 60 activates B cells via the TLR4-MyD88 pathwayQ24321315
Protein folding in the cellQ29547792
Molecular identification of a danger signal that alerts the immune system to dying cellsQ29619497
The Escherichia coli baby cell column: a novel cell synchronization method provides new insight into the bacterial cell cycleQ34278217
A bacterial flagellin, Vibrio vulnificus FlaB, has a strong mucosal adjuvant activity to induce protective immunityQ34301259
Flagellin is an effective adjuvant for immunization against lethal respiratory challenge with Yersinia pestisQ34334406
Roles of heat-shock proteins in innate and adaptive immunityQ34576423
P433issue7
P407language of work or nameEnglishQ1860
P1104number of pages6
P304page(s)4479-4484
P577publication date2006-12-18
P1433published inJournal of Biological ChemistryQ867727
P1476titleFlagellin contamination of recombinant heat shock protein 70 is responsible for its activity on T cells.
P478volume282

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cites work (P2860)
Q28730158A New-Age for Biologic Therapies: Long-Term Drug-Free Therapy with BiP?
Q38620773Antigen Cross-Presentation and Heat Shock Protein-Based Vaccines
Q34737718Bacterial infection elicits heat shock protein 72 release from pleural mesothelial cells
Q36710590Burkholderia pseudomallei infection of T cells leads to T-cell costimulation partially provided by flagellin
Q34484602Burkholderia pseudomallei proteins presented by monocyte-derived dendritic cells stimulate human memory T cells in vitro
Q40421548Calcium signaling in dendritic cells by human or mycobacterial Hsp70 is caused by contamination and is not required for Hsp70-mediated enhancement of cross-presentation
Q36482156Calreticulin requires an ancillary adjuvant for the induction of efficient cytotoxic T cell responses
Q37592040Caught with their PAMPs down? The extracellular signalling actions of molecular chaperones are not due to microbial contaminants
Q26994999Cell death and DAMPs in acute pancreatitis
Q33581297Chaperokine function of recombinant Hsp72 produced in insect cells using a baculovirus expression system is retained
Q38286381Could mycobacterial Hsp70-containing fusion protein lead the way to an affordable therapeutic cancer vaccine?
Q37744071Designing CD8+ T cell vaccines: it's not rocket science (yet).
Q39216608Efficacy of indirect ELISA for serodiagnosis of melioidosis using immunodominant antigens from non-pathogenic Burkholderia thailandensis
Q41907493Elevated expression of the toll like receptors 2 and 4 in obese individuals: its significance for obesity-induced inflammation.
Q37273605Endogenous signals initiating inflammation in the injured nervous system
Q43592344Exogenous heat shock protein 27 uniquely blocks differentiation of monocytes to dendritic cells.
Q58568805Heat Shock Proteins as Immunomodulants
Q36613524Heat shock proteins HSP27 and HSP70 are present in the skin and are important mediators of allergic contact hypersensitivity
Q37825717Heat shock proteins and high mobility group box 1 protein lack cytokine function
Q37411827Heat shock proteins and immune system
Q42144085Heat shock proteins: conditional mediators of inflammation in tumor immunity
Q37290102Heat-shock proteins as powerful weapons in vaccine development
Q34738862Hsp110-mediated enhancement of CD4+ T cell responses to the envelope glycoprotein of members of the family Flaviviridae in vitro does not occur in vivo
Q37231027Hsp70 and cardiac surgery: molecular chaperone and inflammatory regulator with compartmentalized effects
Q34660530Human heat shock protein 70 enhances tumor antigen presentation through complex formation and intracellular antigen delivery without innate immune signaling.
Q42554841Inducible heat shock protein 70 reduces T cell responses and stimulatory capacity of monocyte-derived dendritic cells
Q41874130Innate Pathways of Immune Activation in Transplantation
Q34289171Ligation of TLR5 promotes myeloid cell infiltration and differentiation into mature osteoclasts in rheumatoid arthritis and experimental arthritis
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Q39264188Positive feedback regulation of heat shock protein 70 (Hsp70) is mediated through Toll-like receptor 4-PI3K/Akt-glycogen synthase kinase-3β pathway
Q37857299Recombinant complexes of antigen with stress proteins are potent CD8 T-cell-stimulating immunogens
Q51058291Stress-activated dendritic cells interact with CD4+ T cells to elicit homeostatic memory.
Q45384441TLR5 stimulation is sufficient to trigger reactivation of latent HIV-1 provirus in T lymphoid cells and activate virus gene expression in central memory CD4+ T cells
Q36733882TLR5, a novel and unidentified inflammatory mediator in rheumatoid arthritis that correlates with disease activity score and joint TNF-α levels
Q38555406The danger model: questioning an unconvincing theory
Q57090611Toll-Like Receptor Signaling Is Critical for Wallerian Degeneration and Functional Recovery after Peripheral Nerve Injury

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