Enterohaemorrhagic Escherichia coli Tir requires a C-terminal 12-residue peptide to initiate EspF-mediated actin assembly and harbours N-terminal sequences that influence pedestal length.

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Enterohaemorrhagic Escherichia coli Tir requires a C-terminal 12-residue peptide to initiate EspF-mediated actin assembly and harbours N-terminal sequences that influence pedestal length. is …
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scholarly articleQ13442814

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P356DOI10.1111/J.1462-5822.2006.00728.X
P698PubMed publication ID16922867
P5875ResearchGate publication ID6865044

P2093author name stringJohn M Leong
Kenneth G Campellone
Daniel C Rowe
Brian M Skehan
Judith G Alamares
Donald J Tipper
Michael J Brady
P2860cites workStructural basis for recognition of the translocated intimin receptor (Tir) by intimin from enteropathogenic Escherichia coliQ24685613
Crystal structure of enteropathogenic Escherichia coli intimin-receptor complexQ27625285
Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathwayQ28187612
Pathogenic Escherichia coliQ29616738
Inducible clustering of membrane-targeted SH3 domains of the adaptor protein Nck triggers localized actin polymerizationQ30164319
Self-association of EPEC intimin mediated by the beta-barrel-containing anchor domain: a role in clustering of the Tir receptorQ30164370
Involvement of the intermediate filament protein cytokeratin-18 in actin pedestal formation during EPEC infectionQ33196595
Enteropathogenic E. coli Tir binds Nck to initiate actin pedestal formation in host cellsQ33292526
A genetic locus of enteropathogenic Escherichia coli necessary for the production of attaching and effacing lesions on tissue culture cellsQ33834748
Distribution of tccP in clinical enterohemorrhagic and enteropathogenic Escherichia coli isolatesQ34143709
A comparison of enteropathogenic and enterohaemorrhagic Escherichia coli pathogenesis.Q34489925
Intestinal epithelial responses to enteric pathogens: effects on the tight junction barrier, ion transport, and inflammationQ35065323
Tails of two Tirs: actin pedestal formation by enteropathogenic E. coli and enterohemorrhagic E. coli O157:H7.Q35077208
EPEC's weapons of mass subversionQ36032356
Enteropathogenic and enterohemorrhagic Escherichia coli infections: translocation, translocation, translocationQ36104202
Clustering of Nck by a 12-residue Tir phosphopeptide is sufficient to trigger localized actin assemblyQ36322209
Enteropathogenic Escherichia coli use redundant tyrosine kinases to form actin pedestals.Q37031466
Identification of CesT, a chaperone for the type III secretion of Tir in enteropathogenic Escherichia coli.Q38319836
Enteropathogenic Escherichia coli translocated intimin receptor, Tir, requires a specific chaperone for stable secretionQ38319840
Cortactin is necessary for F-actin accumulation in pedestal structures induced by enteropathogenic Escherichia coli infectionQ39654466
TccP is an enterohaemorrhagic Escherichia coli O157:H7 type III effector protein that couples Tir to the actin-cytoskeletonQ40495870
Potential role of the EPEC translocated intimin receptor (Tir) in host apoptotic eventsQ40645212
Point mutants of EHEC intimin that diminish Tir recognition and actin pedestal formation highlight a putative Tir binding pocketQ40700897
The Tir-binding region of enterohaemorrhagic Escherichia coli intimin is sufficient to trigger actin condensation after bacterial-induced host cell signallingQ41481125
The enterohaemorrhagic Escherichia coli (serotype O157:H7) Tir molecule is not functionally interchangeable for its enteropathogenic E. coli (serotype O127:H6) homologueQ42656259
Phosphorylation of the enteropathogenic E. coli receptor by the Src-family kinase c-Fyn triggers actin pedestal formationQ42827785
Enterohaemorrhagic and enteropathogenic Escherichia coli use a different Tir-based mechanism for pedestal formationQ43753252
Phosphoserine modification of the enteropathogenic Escherichia coli Tir molecule is required to trigger conformational changes in Tir and efficient pedestal elongationQ43910848
A tyrosine-phosphorylated 12-amino-acid sequence of enteropathogenic Escherichia coli Tir binds the host adaptor protein Nck and is required for Nck localization to actin pedestalsQ43936783
EspFU is a translocated EHEC effector that interacts with Tir and N-WASP and promotes Nck-independent actin assemblyQ45008620
Actin and alpha-actinin dynamics in the adhesion and motility of EPEC and EHEC on host cellsQ45207808
Comparison of Tir from enterohemorrahgic and enteropathogenic Escherichia coli strains: two homologues with distinct intracellular properties.Q46756068
Insertion of the enteropathogenic Escherichia coli Tir virulence protein into membranes in vitro.Q46911375
EspE, a novel secreted protein of attaching and effacing bacteria, is directly translocated into infected host cells, where it appears as a tyrosine-phosphorylated 90 kDa proteinQ47956651
Enteropathogenic E. coli (EPEC) transfers its receptor for intimate adherence into mammalian cellsQ48042079
A carboxy-terminal domain of Tir from enterohemorrhagic Escherichia coli O157:H7 (EHEC O157:H7) required for efficient type III secretion.Q54492076
The N-terminus of enteropathogenic Escherichia coli (EPEC) Tir mediates transport across bacterial and eukaryotic cell membranes.Q54535771
P433issue9
P921main subjectEscherichia coliQ25419
P304page(s)1488-1503
P577publication date2006-09-01
P1433published inCellular MicrobiologyQ1921948
P1476titleEnterohaemorrhagic Escherichia coli Tir requires a C-terminal 12-residue peptide to initiate EspF-mediated actin assembly and harbours N-terminal sequences that influence pedestal length.
P478volume8

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cites work (P2860)
Q46479145Actin cytoskeleton manipulation by effector proteins secreted by diarrheagenic Escherichia coli pathotypes
Q40953710Amino acid residues within enterohemorrhagic Escherichia coli O157:H7 Tir involved in phosphorylation, alpha-actinin recruitment, and Nck-independent pedestal formation
Q37021415Attaching effacing Escherichia coli and paradigms of Tir-triggered actin polymerization: getting off the pedestal
Q30157618Cortactin recruitment by enterohemorrhagic Escherichia coli O157:H7 during infection in vitro and ex vivo
Q37755414Cytoskeleton-modulating effectors of enteropathogenic and enterohaemorrhagic Escherichia coli: Tir, EspFU and actin pedestal assembly
Q33621525Dissecting the role of the Tir:Nck and Tir:IRTKS/IRSp53 signalling pathways in vivo
Q38337459EHEC Adhesins
Q33680472Enterohemorrhagic E. coli Requires N-WASP for Efficient Type III Translocation but Not for EspFU-Mediated Actin Pedestal Formation
Q41753440EspFU, a type III-translocated effector of actin assembly, fosters epithelial association and late-stage intestinal colonization by E. coli O157:H7.
Q97523308High formin binding protein 17 (FBP17) expression indicates poor differentiation and invasiveness of ductal carcinomas
Q24315675Insulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspF(U) during pedestal formation
Q38127457Intimate host attachment: enteropathogenic and enterohaemorrhagic Escherichia coli
Q37780578LEEways: tales of EPEC, ATEC and EHEC.
Q30010120Membrane-deforming proteins play distinct roles in actin pedestal biogenesis by enterohemorrhagic Escherichia coli.
Q37144929Modelling of infection by enteropathogenic Escherichia coli strains in lineages 2 and 4 ex vivo and in vivo by using Citrobacter rodentium expressing TccP
Q33381584Repetitive N-WASP-binding elements of the enterohemorrhagic Escherichia coli effector EspF(U) synergistically activate actin assembly.
Q30418173Serine protease EspP from enterohemorrhagic Escherichia coli is sufficient to induce shiga toxin macropinocytosis in intestinal epithelium
Q27673160Structural basis for complex formation between human IRSp53 and the translocated intimin receptor Tir of enterohemorrhagic E. coli.
Q27651305Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspFU
Q33915630Study of polymorphisms in tir, eae and tccP2 genes in enterohaemorrhagic and enteropathogenic Escherichia coli of serogroup O26.
Q35689242TccP2 of O157:H7 and non-O157 enterohemorrhagic Escherichia coli (EHEC): challenging the dogma of EHEC-induced actin polymerization
Q33910276TccP2-mediated subversion of actin dynamics by EPEC 2 - a distinct evolutionary lineage of enteropathogenic Escherichia coli
Q38981719Type III Secreted Virulence Factors Manipulating Signaling to Actin Dynamics.

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