Astaxanthin attenuates the UVB-induced secretion of prostaglandin E2 and interleukin-8 in human keratinocytes by interrupting MSK1 phosphorylation in a ROS depletion-independent manner.

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Astaxanthin attenuates the UVB-induced secretion of prostaglandin E2 and interleukin-8 in human keratinocytes by interrupting MSK1 phosphorylation in a ROS depletion-independent manner. is …
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scholarly articleQ13442814

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P356DOI10.1111/J.1600-0625.2012.01496.X
P698PubMed publication ID22626465

P2093author name stringGenji Imokawa
Hiroaki Nakajima
Shuko Terazawa
Takao Niwano
Mori Shingo
P2860cites workInhibition of ultraviolet B-mediated activation of nuclear factor kappaB in normal human epidermal keratinocytes by green tea Constituent (-)-epigallocatechin-3-gallateQ44319791
Activation of apoptosis signal-regulating kinase 1 by reactive oxygen species through dephosphorylation at serine 967 and 14-3-3 dissociationQ44701428
All-trans-retinoic acid induces interleukin-8 via the nuclear factor-kappaB and p38 mitogen-activated protein kinase pathways in normal human keratinocytes.Q45195283
Suppressive effects of astaxanthin against rat endotoxin-induced uveitis by inhibiting the NF-kappaB signaling pathwayQ46673133
Emodin inhibits TNF alpha-induced MMP-1 expression through suppression of activator protein-1 (AP-1).Q53589125
Ferritin Heavy Chain Upregulation by NF-κB Inhibits TNFα-Induced Apoptosis by Suppressing Reactive Oxygen SpeciesQ58419541
Cloning and characterization of RLPK, a novel RSK-related protein kinaseQ22008607
IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domainQ22010650
Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)Q24297420
Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREBQ24319704
Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.Q24533236
MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblastsQ24537233
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assaysQ25939005
Ser276 phosphorylation of NF-kB p65 by MSK1 controls SCF expression in inflammationQ28118400
Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatasesQ28239642
Regulation of UVB-induced IL-8 and MCP-1 production in skin keratinocytes by increasing vitamin C uptake via the redistribution of SVCT-1 from the cytosol to the membraneQ28266020
Characterization of the p90 ribosomal S6 kinase 2 carboxyl-terminal domain as a protein kinaseQ28508972
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Differential regulation of iron chelator-induced IL-8 synthesis via MAP kinase and NF-kappaB in immortalized and malignant oral keratinocytesQ33298692
Homoisoflavanone inhibits UVB-induced skin inflammation through reduced cyclooxygenase-2 expression and NF-kappaB nuclear localizationQ34132188
Increased prostaglandins E2 and F2alpha in human skin at 6 and 24 h after ultraviolet B irradiation (290- 320 nm)Q34516526
Suppression of ultraviolet B exposure-mediated activation of NF-kappaB in normal human keratinocytes by resveratrolQ34532343
Dimethylfumarate specifically inhibits the mitogen and stress-activated kinases 1 and 2 (MSK1/2): possible role for its anti-psoriatic effect.Q34627517
Metabolic switches of T-cell activation and apoptosisQ34820763
Inhibition of lipopolysaccharide‐inducible nitric oxide synthase, TNF‐α and COX‐2 expression by sauchinone effects on I‐κBα phosphorylation, C/EBP and AP‐1 activationQ35045262
Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signalingQ37060629
Antioxidant functions of carotenoidsQ38765343
An extract of Melia toosendan attenuates endothelin-1-stimulated pigmentation in human epidermal equivalents through the interruption of PKC activity within melanocytesQ39569615
Down-regulation of IL-6 production by astaxanthin via ERK-, MSK-, and NF-κB-mediated signals in activated microgliaQ39646722
Role of HuR and p38MAPK in ultraviolet B-induced post-transcriptional regulation of COX-2 expression in the human keratinocyte cell line HaCaT.Q39773895
Hsp27 regulates pro-inflammatory mediator release in keratinocytes by modulating NF-kappaB signalingQ40050381
Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS.Q40206010
Troglitazone induction of COX-2 expression is dependent on ERK activation in keratinocytesQ40323309
Contribution of protein kinase A and protein kinase C pathways in ultraviolet B-induced IL-8 expression by human keratinocytes.Q40448116
MSK1 activity is controlled by multiple phosphorylation sites.Q40487132
IGF-II-mediated COX-2 gene expression in human keratinocytes through extracellular signal-regulated kinase pathwayQ40526812
Role of p38 MAP kinases and ERK in mediating ultraviolet-B induced cyclooxygenase-2 gene expression in human keratinocytesQ40794472
Mitogen- and stress-activated protein kinase 1 is activated in lesional psoriatic epidermis and regulates the expression of pro-inflammatory cytokinesQ42492251
Quercetin inhibits UV irradiation-induced inflammatory cytokine production in primary human keratinocytes by suppressing NF-κB pathwayQ42753544
Astaxanthin attenuates the UVA-induced up-regulation of matrix-metalloproteinase-1 and skin fibroblast elastase in human dermal fibroblastsQ43135139
Ultraviolet-B-induced erythema is mediated by nitric oxide and prostaglandin E2 in combinationQ43776988
P921main subjectastaxanthinQ413740
prostaglandin E2Q416554
keratinocyteQ1473931
interleukinsQ194908
phosphorylationQ242736
P304page(s)11-17
P577publication date2012-07-01
P1433published inExperimental DermatologyQ15749509
P1476titleAstaxanthin attenuates the UVB-induced secretion of prostaglandin E2 and interleukin-8 in human keratinocytes by interrupting MSK1 phosphorylation in a ROS depletion-independent manner.
P478volume21 Suppl 1

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cites work (P2860)
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Q36132207Antiinflammatory and Antiphotodamaging Effects of Ergostatrien-3β-ol, Isolated from Antrodia camphorata, on Hairless Mouse Skin.
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