Enhanced antitumor activity and selectivity of lactoferrin-derived peptides.

scientific article

Enhanced antitumor activity and selectivity of lactoferrin-derived peptides. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1034/J.1399-3011.2002.21008.X
P698PubMed publication ID12366526
P5875ResearchGate publication ID11091976

P50authorJohn Sigurd SvendsenQ42978817
P2093author name stringYang N
Stensen W
Rekdal Ø
P2860cites workMagainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursorQ24569680
Refined three-dimensional solution structure of insect defensin AQ27729857
Three-dimensional structure of diferric bovine lactoferrin at 2.8 A resolutionQ27748329
Empirical Predictions of Protein ConformationQ28300310
Increased antibacterial activity of 15-residue murine lactoferricin derivativesQ31902997
Diversity of antimicrobial peptides and their mechanisms of actionQ33789705
Structural features of helical antimicrobial peptides: their potential to modulate activity on model membranes and biological cellsQ33789720
Antimicrobial activity of synthetic magainin peptides and several analoguesQ37486659
Antibiotic magainins exert cytolytic activity against transformed cell lines through channel formationQ37498093
Identification of serum components that inhibit the tumoricidal activity of amphiphilic alpha helical peptidesQ41579861
Insect immunity: isolation and structure of cecropin D and four minor antibacterial components from Cecropia pupaeQ42076879
Effects of the hinge region of cecropin A(1-8)-magainin 2(1-12), a synthetic antimicrobial peptide, on liposomes, bacterial and tumor cellsQ42805350
The role of tryptophan in the antibacterial activity of a 15-residue bovine lactoferricin peptideQ43608811
Effects of mellitin on the central nervous systemQ48447533
Physicochemical determinants for the interactions of magainins 1 and 2 with acidic lipid bilayersQ48768228
Effects on electrophoretic mobility and antibacterial spectrum of removal of two residues from synthetic sarcotoxin IA and addition of the same residues to cecropin BQ52461693
Contributions of tryptophan side chains to the far-ultraviolet circular dichroism of proteins.Q52879960
Influence of the angle subtended by the positively charged helix face on the membrane activity of amphipathic, antibacterial peptides.Q52998392
Hydrophobicity, hydrophobic moment and angle subtended by charged residues modulate antibacterial and haemolytic activity of amphipathic helical peptides.Q53001349
Peptide helicity and membrane surface charge modulate the balance of electrostatic and hydrophobic interactions with lipid bilayers and biological membranes.Q53004836
Determination of hydrophobic parameters by reversed-phase liquid chromatography: theory, experimental techniques, and application in studies on quantitative structure-activity relationshipsQ68929170
A water-soluble aminated beta 1-3D-glucan derivative causes regression of solid tumors in miceQ69744669
Molecular basis for prokaryotic specificity of magainin-induced lysisQ72125585
Antibacterial activity of 15-residue lactoferricin derivativesQ73233553
Antibiotic activity of pentadecapeptides modelled from amino acid descriptorsQ73691202
Lactoferricin of bovine origin is more active than lactoferricins of human, murine and caprine originQ74582662
Structure-antibacterial, antitumor and hemolytic activity relationships of cecropin A-magainin 2 and cecropin A-melittin hybrid peptidesQ77296547
P433issue4
P304page(s)187-197
P577publication date2002-10-01
P1433published inChemical Biology and Drug DesignQ15749458
P1476titleEnhanced antitumor activity and selectivity of lactoferrin-derived peptides.
P478volume60

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cites work (P2860)
Q36328218A tetrameric peptide derived from bovine lactoferricin as a potential therapeutic tool for oral squamous cell carcinoma: A preclinical model
Q38269264Anticancer effects of lactoferrin: underlying mechanisms and future trends in cancer therapy.
Q39010669Anticancer potency of small linear and cyclic tetrapeptides and pharmacokinetic investigations of peptide binding to human serum albumin.
Q38941806Antimicrobial peptide GW-H1-induced apoptosis of human gastric cancer AGS cell line is enhanced by suppression of autophagy
Q39840364Application of thermally responsive elastin-like polypeptide fused to a lactoferrin-derived peptide for treatment of pancreatic cancer.
Q38943851Bovine lactoferrin induces cell cycle arrest and inhibits mTOR signaling in breast cancer cells.
Q33624296Complete regression and systemic protective immune responses obtained in B16 melanomas after treatment with LTX-315.
Q38491362In search of a novel target - phosphatidylserine exposed by non-apoptotic tumor cells and metastases of malignancies with poor treatment efficacy
Q39788897Knowledge-based computational methods for identifying or designing novel, non-homologous antimicrobial peptides
Q38685556LTX-315: a first-in-class oncolytic peptide that reprograms the tumor microenvironment
Q39122539Novel cytotoxic exhibition mode of antimicrobial peptide anoplin in MEL cells, the cell line of murine Friend leukemia virus-induced leukemic cells.
Q35600198Oncolytic activities of host defense peptides
Q39447406Relative spatial positions of tryptophan and cationic residues in helical membrane-active peptides determine their cytotoxicity.
Q33858892Small lytic peptides escape the inhibitory effect of heparan sulfate on the surface of cancer cells
Q46264556Structural determinants of antimicrobial and antiplasmodial activity and selectivity in histidine-rich amphipathic cationic peptides
Q35924903The Cytolytic Amphipathic β(2,2)-Amino Acid LTX-401 Induces DAMP Release in Melanoma Cells and Causes Complete Regression of B16 Melanoma
Q38260167The oncolytic peptide LTX-315 induces cell death and DAMP release by mitochondria distortion in human melanoma cells
Q35117090The therapeutic potential of lactoferrin

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