Reduced alpha-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease.

scientific article

Reduced alpha-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1136/GUT.2007.142588
P698PubMed publication ID18305068

P50authorJames DoeckeQ56704968
P2093author name stringN Huang
M D Walsh
G L Radford-Smith
E V Fowler
L A Simms
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectCrohn's diseaseQ1472
inflammationQ101991
P304page(s)903-910
P577publication date2008-02-27
P1433published inGutQ5621669
P1476titleReduced alpha-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease
P478volume57

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cites work (P2860)
Q41904813A common role for Atg16L1, Atg5 and Atg7 in small intestinal Paneth cells and Crohn disease
Q35079575A small intestinal organoid model of non-invasive enteric pathogen-epithelial cell interactions
Q57098797Abnormal Small Intestinal Epithelial Microvilli in Patients With Crohn's Disease
Q36174042Actin reorganization as the molecular basis for the regulation of apoptosis in gastrointestinal epithelial cells
Q46097846Activation of NOD2-mediated intestinal pathway in a pediatric population with Crohn's disease
Q36155351Acute Infectious Gastroenteritis Potentiates a Crohn's Disease Pathobiont to Fuel Ongoing Inflammation in the Post-Infectious Period
Q34627198Adherent-invasive E. coli in Crohn disease: bacterial "agent provocateur"
Q38194867Advances in IBD genetics
Q61865732Age-of-diagnosis dependent ileal immune intensification and reduced alpha-defensin in older versus younger pediatric Crohn Disease patients despite already established dysbiosis
Q47343886Alpha-defensins (α-Defs) in Crohn's disease: decrease of ileal α-Def 5 via permanent methylation and increase in plasma α-Def 1-3 concentrations offering biomarker utility
Q38928108Alterations in microRNA expression profiles in inflamed and non-inflamed ascending colon mucosae of patients with active Crohn';s disease
Q94464395An Update Review on the Paneth Cell as Key to Ileal Crohn's Disease
Q38040831Antimicrobial peptides and colitis
Q34987870Antimicrobial peptides and gut microbiota in homeostasis and pathology.
Q41477282Antimicrobial peptides in gastrointestinal inflammation
Q27023239Antimicrobial proteins in intestine and inflammatory bowel diseases
Q37845328Are NOD2 polymorphisms linked to a specific disease endophenotype of Crohn's disease?
Q34185576Association of a functional variant in the Wnt co-receptor LRP6 with early onset ileal Crohn's disease
Q41882233Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection
Q38065286Autophagy and intestinal homeostasis
Q34024046Barrier- and autophagic functions of the intestinal epithelia: role of disturbances in the pathogenesis of Crohn’s disease
Q28740558CEACAM6 gene variants in inflammatory bowel disease
Q42589189Carbohydrate Elimination or Adaptation Diet for Symptoms of Intestinal Discomfort in IBD: Rationales for "Gibsons' Conundrum".
Q35190723Cellular and molecular mechanisms underlying NOD2 risk-associated polymorphisms in Crohn's disease.
Q34391698Characteristic changes in microbial community composition and expression of innate immune genes in acute appendicitis.
Q43849278Characterization of intestinal gene expression profiles in Crohn's disease by genome-wide microarray analysis.
Q37878446Characterization of the gastrointestinal microbiota in health and inflammatory bowel disease.
Q50054942Chronic cigarette smoke exposure induces systemic hypoxia that drives intestinal dysfunction.
Q64110872Contribution of Zinc and Zinc Transporters in the Pathogenesis of Inflammatory Bowel Diseases
Q41441733Controversy over NOD2, inflammation, and defensins
Q35122791Critical design aspects involved in the study of Paneth cells and the intestinal microbiota
Q34132601Crohn disease: a current perspective on genetics, autophagy and immunity
Q37276947Crohn's disease--defect in innate defence.
Q35825462Crohn's disease-derived monocytes fail to induce Paneth cell defensins
Q38177269Debug Your Bugs - How NLRs Shape Intestinal Host-Microbe Interactions
Q35969912Decreased Pregnane X Receptor Expression in Children with Active Crohn's Disease
Q34212591Deregulated inflammasome signaling in disease
Q41422696Deregulation of transcription factors controlling intestinal epithelial cell differentiation; a predisposing factor for reduced enteroendocrine cell number in morbidly obese individuals.
Q47963300Differential effects of Staphylococcal enterotoxin B-mediated immune activation on intestinal defensins.
Q97521540Does an Apple a Day Also Keep the Microbes Away? The Interplay Between Diet, Microbiota, and Host Defense Peptides at the Intestinal Mucosal Barrier
Q51829378Donkey milk consumption exerts anti-inflammatory properties by normalizing antimicrobial peptides levels in Paneth's cells in a model of ileitis in mice.
Q40365738Dysbiosis in Crohn's disease - Joint action of stochastic injuries and focal inflammation in the gut.
Q37719188ER stress and the unfolded protein response in intestinal inflammation.
Q53290904Early modulation of gene expression used as a biomarker for chemoprevention in a preclinical model of colon carcinogenesis.
Q37351981Esophageal human β-defensin expression in eosinophilic esophagitis.
Q24623064Evolution of host innate defence: insights from Caenorhabditis elegans and primitive invertebrates
Q57100645Expression of neutrophil gelatinase-associated lipocalin (NGAL) in the gut in Crohn's disease
Q37930993From intestinal stem cells to inflammatory bowel diseases
Q24647448Function of Nod-like receptors in microbial recognition and host defense
Q33755171Growth Hormone Resistance-Special Focus on Inflammatory Bowel Disease.
Q28294695Gut microbiota and IBD
Q24631660Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease (*)
Q34058861Host defense peptide resistance contributes to colonization and maximal intestinal pathology by Crohn's disease-associated adherent-invasive Escherichia coli.
Q34311665Host genes related to paneth cells and xenobiotic metabolism are associated with shifts in human ileum-associated microbial composition
Q37302559Host-bacteria interaction in inflammatory bowel disease
Q37675501How the noninflammasome NLRs function in the innate immune system
Q34628470Immunopathogenesis of inflammatory bowel disease
Q37798821Impact ofClostridium difficileon inflammatory bowel disease
Q34093119Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum
Q39237282Inflammasomes and intestinal inflammation
Q29615500Inflammatory bowel disease
Q29616286Inflammatory bowel disease
Q34312402Inflammatory bowel disease: an impaired barrier disease
Q34311640Inflammatory bowel diseases phenotype, C. difficile and NOD2 genotype are associated with shifts in human ileum associated microbial composition
Q33554402Interactions between the host innate immune system and microbes in inflammatory bowel disease
Q57119838Intestinal alpha-defensin expression in pediatric inflammatory bowel disease
Q38054086Intestinal antimicrobial peptides during homeostasis, infection, and disease
Q38293757Intestinal barrier homeostasis in inflammatory bowel disease.
Q39388017Intestinal barrier integrity and inflammatory bowel disease: Stem cell-based approaches to regenerate the barrier.
Q34007118Intestinal dysbiosis and bacterial enteroinvasion in a murine model of Hirschsprung's disease.
Q37925059Intracellular sensors of extracellular bacteria
Q44531487KCNN4 gene variant is associated with ileal Crohn's Disease in the Australian and New Zealand population
Q40628192Lack of intestinal epithelial atg7 affects paneth cell granule formation but does not compromise immune homeostasis in the gut.
Q90633681Lactobacillus reuteri 5454 and Bifidobacterium animalis ssp. lactis 5764 improve colitis while differentially impacting dendritic cells maturation and antimicrobial responses
Q33956751MDP-NOD2 stimulation induces HNP-1 secretion, which contributes to NOD2 antibacterial function
Q39141466Methanolic extract of white asparagus shoots activates TRAIL apoptotic death pathway in human cancer cells and inhibits colon carcinogenesis in a preclinical model
Q33765449Microbes, the gut and ankylosing spondylitis
Q36273576Microgeographic Proteomic Networks of the Human Colonic Mucosa and Their Association With Inflammatory Bowel Disease
Q37351171Mouse Paneth cell antimicrobial function is independent of Nod2.
Q30945619Mucosal gene expression of antimicrobial peptides in inflammatory bowel disease before and after first infliximab treatment
Q30497993NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis
Q38171221NOD proteins: regulators of inflammation in health and disease
Q34745603NOD1 and NOD2: signaling, host defense, and inflammatory disease
Q46269946NOD2 and bacterial recognition as therapeutic targets for Crohn's disease.
Q55000637NOD2 and inflammation: current insights.
Q37727940NOD2 status and human ileal gene expression.
Q37172148NOD2, an intracellular innate immune sensor involved in host defense and Crohn's disease
Q42206092New treatment options in the management of IBD - focus on colony stimulating factors.
Q39203747Nicotinamide treatment ameliorates the course of experimental colitis mediated by enhanced neutrophil-specific antibacterial clearance
Q37886430Nod-like receptors in intestinal homeostasis, inflammation, and cancer
Q37354181Nod2 is required for the regulation of commensal microbiota in the intestine
Q28079236Nod2: A Critical Regulator of Ileal Microbiota and Crohn's Disease
Q34210133Nod2: a key regulator linking microbiota to intestinal mucosal immunity
Q57124250Over-expression of paneth cell-derived anti-microbial peptides in the gut of patients with ankylosing spondylitis and subclinical intestinal inflammation
Q50005480Paneth and intestinal stem cells preserve their functional integrity during worsening of acute cellular rejection in small bowel transplantation
Q26747303Paneth cell α-defensins and enteric microbiota in health and disease
Q54374775Paneth's disease.
Q38551892Pathogenesis of Clostridium difficile Infection and Its Potential Role in Inflammatory Bowel Disease.
Q35659341Pathogenesis of Crohn's disease
Q37087891Pro-inflammatory and pro-apoptotic properties of Human Defensin 5.
Q57156865Proteomics and Lipidomics in Inflammatory Bowel Disease Research: From Mechanistic Insights to Biomarker Identification
Q34996068Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes
Q36685310Regulation of intestinal microbiota by the NLR protein family
Q34407175Role of the gut microbiota in inflammatory bowel disease pathogenesis: what have we learnt in the past 10 years?
Q57154682Smoking behaviour modifiesIL23r-associated disease risk in patients with Crohn's disease
Q54357723Suppression of p21Rac signaling and increased innate immunity mediate remission in Crohn's disease.
Q37419561The Gdac1 locus modifies spontaneous and Salmonella-induced colitis in mice deficient in either Gpx2 or Gpx1 gene
Q37633135The Interplay between Defensins and Microbiota in Crohn's Disease
Q30994539The NOD2 single nucleotide polymorphisms rs2066843 and rs2076756 are novel and common Crohn's disease susceptibility gene variants
Q34762033The Nlrp3 inflammasome: contributions to intestinal homeostasis
Q39444977The Risk of Inflammatory Bowel Disease Flares after Fecal Microbiota Transplantation: Systematic Review and Meta-Analysis.
Q37171800The genetics and immunopathogenesis of inflammatory bowel disease
Q37947675The role of human defensins in gastrointestinal diseases
Q38115440The role of the immune system in governing host-microbe interactions in the intestine
Q42636973Transcription factor TFEB cell-autonomously modulates susceptibility to intestinal epithelial cell injury in vivo
Q38972852Understanding the regulation of pattern recognition receptors in inflammatory diseases - a 'Nod' in the right direction
Q37502679Unleashing the therapeutic potential of NOD-like receptors
Q34611580Whole genome gene expression meta-analysis of inflammatory bowel disease colon mucosa demonstrates lack of major differences between Crohn's disease and ulcerative colitis