Myc and a Cdk2 senescence switch.

scientific article published in January 2010

Myc and a Cdk2 senescence switch. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/NCB0110-7
P698PubMed publication ID20027199

P50authorJan van RiggelenQ84411286
P2093author name stringDean W Felsher
P2860cites workCellular senescence: when bad things happen to good cellsQ29615561
Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformationQ33591386
Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16(INK4a).Q34574445
Defective double-strand DNA break repair and chromosomal translocations by MYC overexpressionQ35814896
Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivationQ35928960
Intrinsic tumour suppressionQ35953133
Myc's broad reachQ37299032
Cdk2 suppresses cellular senescence induced by the c-myc oncogene.Q39763259
Werner syndrome protein limits MYC-induced cellular senescenceQ39895677
C-MYC overexpression is required for continuous suppression of oncogene-induced senescence in melanoma cellsQ39954044
MYC can enforce cell cycle transit from G1 to S and G2 to S, but not mitotic cellular division, independent of p27-mediated inihibition of cyclin E/CDK2.Q40270191
CDK2 is required by MYC to induce apoptosisQ40270196
E2F1 and c-Myc potentiate apoptosis through inhibition of NF-kappaB activity that facilitates MnSOD-mediated ROS eliminationQ42814364
c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instabilityQ74243929
A matter of life and cell deathQ77164675
P433issue1
P304page(s)7-9
P577publication date2010-01-01
P1433published inNature Cell BiologyQ1574111
P1476titleMyc and a Cdk2 senescence switch.
P478volume12