Calcineurin independent development of myocardial hypertrophy in transgenic rats overexpressing the mouse renin gene, TGR(mREN2)27.

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Calcineurin independent development of myocardial hypertrophy in transgenic rats overexpressing the mouse renin gene, TGR(mREN2)27. is …
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scholarly articleQ13442814

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P356DOI10.1007/S00109-004-0581-9
P698PubMed publication ID15322704

P2093author name stringK F Frank
R H G Schwinger
C Mei
H Diedrichs
B Boelck
P2860cites workAltered calcium transient and development of hypertrophy in beta2-adrenoceptor overexpressing mice with and without pressure overloadQ73143259
Calcineurin plays a critical role in pressure overload-induced cardiac hypertrophyQ73267718
Proximal tubular fluid, kidney, and plasma levels of angiotensin II in hypertensive ren-2 transgenic ratsQ73645352
GATA4: a novel transcriptional regulator of cardiac hypertrophy?Q73951488
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Involvement of calcineurin in angiotensin II-induced cardiomyocyte hypertrophy and cardiac fibroblast hyperplasia of ratsQ74019951
Signaling path may lead to better heart-failure therapiesQ74516567
Failure of calcineurin inhibitors to prevent pressure-overload left ventricular hypertrophy in ratsQ77215433
Calcineurin inhibitors and cardiac hypertrophyQ77407799
Evidence for calcineurin-mediated regulation of SERCA 2a activity in human myocardiumQ77912853
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Phosphorylation of NFATc4 by p38 mitogen-activated protein kinasesQ24537383
The transcription factor GATA4 is activated by extracellular signal-regulated kinase 1- and 2-mediated phosphorylation of serine 105 in cardiomyocytesQ24548283
Angiotensin II type1a receptor gene expression in the heart: AP-1 and GATA-4 participate in the response to pressure overloadQ24654964
A calcineurin-dependent transcriptional pathway for cardiac hypertrophyQ28269300
Targeted inhibition of calcineurin prevents agonist-induced cardiomyocyte hypertrophyQ28343890
Electrical stimulation of neonatal cardiac myocytes activates the NFAT3 and GATA4 pathways and up-regulates the adenylosuccinate synthetase 1 geneQ28566172
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Signaling in myocardial hypertrophy: life after calcineurin?Q33585726
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Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivoQ34727513
The role of modulatory calcineurin-interacting proteins in calcineurin signalingQ35055274
The hypertensive Ren-2 transgenic rat TGR (mREN2)27 in hypertension research. Characteristics and functional aspectsQ41059187
Factors involved in cardiogenesis and the regulation of cardiac-specific gene expressionQ41222660
The transcription factors GATA4 and GATA6 regulate cardiomyocyte hypertrophy in vitro and in vivo.Q42504443
Angiotensin II induced cardiac hypertrophy in vivo is inhibited by cyclosporin A in adult ratsQ43840391
Specific MAP-kinase blockade protects against renal damage in homozygous TGR(mRen2)27 ratsQ44703364
Unchanged sarcoplasmic reticulum Ca2+-ATPase activity, reduced Ca2+ sensitivity, and negative force-frequency relationship in transgenic rats overexpressing the mouse renin geneQ47861945
Effect of the Na+-channel modulator BDF 9148 on Ca2+-sensitivity and force of contraction of hypertrophic myocardium from transgene rats harboring the mouse Renin gene (TG(mREN2)27).Q47894616
Increased regulatory activity of the calcineurin/NFAT pathway in human heart failureQ47973168
Angiotensin II-Induced Ventricular Hypertrophy and Extracellular Signal-Regulated Kinase Activation Are Suppressed in Mice Overexpressing Brain Natriuretic Peptide in CirculationQ48144427
Calcineurin and human heart failureQ56877814
Angiotensin II receptor blockade in TGR(mREN2)27: effects of renin-angiotensin-system gene expression and cardiovascular functionsQ56963807
Ontogenetic regulation of mouse Ren-2d renin gene in transgenic hypertensive rats, TGR(mREN2)27Q56963870
Differential Activation of Signal Transduction Pathways in Human Hearts With Hypertrophy Versus Advanced Heart FailureQ57396530
Prevention of Cardiac Hypertrophy in Mice by Calcineurin InhibitionQ57396540
Pressure Overload Induces Severe Hypertrophy in Mice Treated With Cyclosporine, an Inhibitor of CalcineurinQ60425260
Revisiting calcineurin and human heart failureQ62397376
Intracellular calcium handling in isolated ventricular myocytes from patients with terminal heart failureQ67486128
Transgenic rats carrying the mouse renin gene--morphological characterization of a low-renin hypertension modelQ68136822
Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failureQ69122833
Unchanged Protein Levels of SERCA II and Phospholamban but Reduced Ca 2+ Uptake and Ca 2+ -ATPase Activity of Cardiac Sarcoplasmic Reticulum From Dilated Cardiomyopathy Patients Compared With Patients With Nonfailing HeartsQ71807622
A one-hour minipreparation technique for extraction of DNA-binding proteins from animal tissuesQ72426100
Comparison of number of extrastimuli versus change in basic cycle length for induction of ventricular tachycardia by programmed ventricular stimulationQ72573772
P433issue10
P921main subjectoverexpressionQ61643320
P304page(s)688-695
P577publication date2004-08-20
P1433published inJournal of Molecular MedicineQ6295593
P1476titleCalcineurin independent development of myocardial hypertrophy in transgenic rats overexpressing the mouse renin gene, TGR(mREN2)27.
P478volume82