Purification and Characterization of Recombinant Botulinum Neurotoxin Serotype FA, Also Known as Serotype H.

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Purification and Characterization of Recombinant Botulinum Neurotoxin Serotype FA, Also Known as Serotype H. is …
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scholarly articleQ13442814

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P356DOI10.3390/TOXINS10050195
P8608Fatcat IDrelease_fkntjvjgcfd3fg7vaqxycuxapy
P932PMC publication ID5983251
P698PubMed publication ID29751611

P2093author name stringKevin Moore
Mark Elliott
Bryony Gray
Matthew Beard
Imran Mir
Fraser Hornby
David Burgin
Gavin Hackett
P2860cites workOnly the complex N559-glycan in the synaptic vesicle glycoprotein 2C mediates high affinity binding to botulinum neurotoxin serotype A1.Q51505838
Expression and purification of catalytically active, non-toxic endopeptidase derivatives of Clostridium botulinum toxin type A.Q54541506
Expression and Purification of the Light Chain of Botulinum Neurotoxin A: A Single Mutation Abolishes Its Cleavage of SNAP-25 and Neurotoxicity after Reconstitution with the Heavy ChainQ54599905
The N-terminal half of the receptor domain of botulinum neurotoxin A binds to microdomains of the plasma membraneQ61662145
Botulinum neurotoxin type A: sequence of amino acids at the N-terminus and around the nicking siteQ68375457
Nicking of single chain Clostridium botulinum type A neurotoxin by an endogenous proteaseQ69521812
Regulation of neurotoxin complex expression in Clostridium botulinum strains 62A, Hall A-hyper, and NCTC 2916Q83345968
Double receptor anchorage of botulinum neurotoxins accounts for their exquisite neurospecificityQ85651745
Validity of botulinum neurotoxin serotype HQ87661789
Discovery of a novel enzymatic cleavage site for botulinum neurotoxin F5Q24299963
Examination of feces and serum for diagnosis of infant botulism in 336 patientsQ24647671
Glycosylated SV2 and Gangliosides as Dual Receptors for Botulinum Neurotoxin Serotype FQ27655649
Structure and activity of a functional derivative of Clostridium botulinum neurotoxin BQ27665891
Structural insights into the functional role of the Hcn sub-domain of the receptor-binding domain of the botulinum neurotoxin mosaic serotype C/DQ27677003
Botulinum Neurotoxin Is Shielded by NTNHA in an Interlocked ComplexQ27677462
Identification of the synaptic vesicle glycoprotein 2 receptor binding site in botulinum neurotoxin AQ28581589
Botulinum neurotoxin type A: cleavage of the heavy chain into two halves and their partial sequencesQ28609194
Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmidsQ33308728
Botulinum neurotoxin D-C uses synaptotagmin I and II as receptors, and human synaptotagmin II is not an effective receptor for type B, D-C and G toxinsQ33793263
Characteristics of Clostridium botulinum Type F Isolated from the Pacific Coast of the United StatesQ33802104
Structural basis of the pH-dependent assembly of a botulinum neurotoxin complex.Q34616143
Clostridium botulinum strain Af84 contains three neurotoxin gene clusters: bont/A2, bont/F4 and bont/F5.Q34700141
Different substrate recognition requirements for cleavage of synaptobrevin-2 by Clostridium baratii and Clostridium botulinum type F neurotoxins.Q34738054
Biology and genomic analysis of Clostridium botulinum.Q34990351
Molecular cloning of the gene encoding the mosaic neurotoxin, composed of parts of botulinum neurotoxin types C1 and D, and PCR detection of this gene from Clostridium botulinum type C organismsQ35188905
Functional characterization of botulinum neurotoxin serotype H as a hybrid of known serotypes F and A (BoNT F/A).Q35910511
Purification and characterization of a protease from Clostridium botulinum type A that nicks single-chain type A botulinum neurotoxin into the di-chain formQ36162224
Unique biological activity of botulinum D/C mosaic neurotoxin in murine speciesQ36211139
Molecular Assembly of Clostridium botulinum progenitor M complex of type EQ36350322
Generation and Characterization of Six Recombinant Botulinum Neurotoxins as Reference Material to Serve in an International Proficiency TestQ36401425
A Novel Botulinum Neurotoxin, Previously Reported as Serotype H, Has a Hybrid-Like Structure With Regions of Similarity to the Structures of Serotypes A and F and Is Neutralized With Serotype A AntitoxinQ36440215
Purification and Characterization of Botulinum Neurotoxin FA from a Genetically Modified Clostridium botulinum StrainQ36891334
Botulinum Neurotoxin Serotype A Recognizes Its Protein Receptor SV2 by a Different Mechanism than Botulinum Neurotoxin B SynaptotagminQ36946982
N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A.Q37276819
Effects of enzymatically inactive recombinant botulinum neurotoxin type A at the mouse neuromuscular junctionsQ37700722
Crystal Structure of the Receptor-Binding Domain of Botulinum Neurotoxin Type HA, Also Known as Type FA or H.Q37727928
Clostridial neurotoxins: mechanism of SNARE cleavage and outlook on potential substrate specificity reengineeringQ37954285
Botulinum neurotoxins: genetic, structural and mechanistic insights.Q38224215
Historical and current perspectives on Clostridium botulinum diversityQ38259821
Simplified purification method for Clostridium botulinum type E toxinQ39926620
Mechanism of substrate recognition by the novel Botulinum Neurotoxin subtype F5.Q40078527
Comparison of toxins of Clostridium butyricum and Clostridium botulinum type E.Q40157907
SV2 is the protein receptor for botulinum neurotoxin A.Q40303506
Sequence diversity of genes encoding botulinum neurotoxin type F.Q41773499
Purification and characterization of a novel subtype a3 botulinum neurotoxinQ42151342
Activation of Clostridium botulinum type E toxin by trypsinQ42242543
Structural analysis of Clostridium botulinum neurotoxin type D as a platform for the development of targeted secretion inhibitorsQ42580273
ADP-ribosylation of 24-26-kDa GTP-binding proteins localized in neuronal and non-neuronal cells by botulinum neurotoxin D.Q42800222
Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptorQ43299518
Exchange of the H(CC) domain mediating double receptor recognition improves the pharmacodynamic properties of botulinum neurotoxinQ43469252
Botulinum neurotoxin types B and E: purification, limited proteolysis by endoproteinase Glu-C and pepsin, and comparison of their identified cleaved sites relative to the three-dimensional structure of type A neurotoxinQ43691688
Molecular characterization of a novel botulinum neurotoxin type H geneQ45290850
A novel strain of Clostridium botulinum that produces type B and type H botulinum toxinsQ45345427
Separation of toxic activity and ADP-ribosylation activity of botulinum neurotoxin D.Q46328631
Mosaic structures of neurotoxins produced from Clostridium botulinum types C and D organismsQ46880568
Substrate cleavage and duration of action of botulinum neurotoxin type FA ("H, HA").Q47257258
Production of catalytically inactive BoNT/A1 holoprotein and comparison with BoNT/A1 subunit vaccines against toxin subtypes A1, A2, and A3.Q47776201
Novel chimeras of botulinum neurotoxins A and E unveil contributions from the binding, translocation, and protease domains to their functional characteristicsQ47783055
Botulinum neurotoxin serotype F is a zinc endopeptidase specific for VAMP/synaptobrevinQ48268335
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P577publication date2018-05-11
P1433published inToxinsQ15724569
P1476titlePurification and Characterization of Recombinant Botulinum Neurotoxin Serotype FA, Also Known as Serotype H.
P478volume10