Gene Regulation During the Enzootic Cycle of the Lyme Disease Spirochete.

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Gene Regulation During the Enzootic Cycle of the Lyme Disease Spirochete. is …
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scholarly articleQ13442814

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P356DOI10.1615/FORUMIMMUNDISTHER.2017019469
P8608Fatcat IDrelease_6m2kmi3q7vd7ll5tscatpqkbmi
P932PMC publication ID5985821
P698PubMed publication ID29876141

P2093author name stringD Scott Samuels
Leah R N Samuels
P2860cites workLyme disease-a tick-borne spirochetosis?Q22242252
Borrelia burgdorferi OspC protein required exclusively in a crucial early stage of mammalian infectionQ24548272
Temporal changes in outer surface proteins A and C of the lyme disease-associated spirochete, Borrelia burgdorferi, during the chain of infection in ticks and miceQ24550778
Borrelia burgdorferi changes its surface antigenic expression in response to host immune responsesQ24561576
Cyclic Di-GMP receptor PlzA controls virulence gene expression through RpoS in Borrelia burgdorferi.Q37548131
RpoS is not central to the general stress response in Borrelia burgdorferi but does control expression of one or more essential virulence determinantsQ37582867
Lyme borreliosis: relation of its causative agent to its vectors and hosts in North America and EuropeQ37672965
Gene regulation in Borrelia burgdorferiQ37908132
ppGpp: magic beyond RNA polymeraseQ37984220
Insights into the biology of Borrelia burgdorferi gained through the application of molecular geneticsQ38174686
Epidemiology of Lyme diseaseQ38496878
BosR (BB0647) governs virulence expression in Borrelia burgdorferi.Q39372859
Dynamics of dissemination and outer surface protein expression of different European Borrelia burgdorferi sensu lato strains in artificially infected Ixodes ricinus nymphsQ39697435
Immunological and molecular polymorphisms of OspC, an immunodominant major outer surface protein of Borrelia burgdorferi.Q40267193
Identification and molecular characterization of a cyclic-di-GMP effector protein, PlzA (BB0733): additional evidence for the existence of a functional cyclic-di-GMP regulatory network in the Lyme disease spirochete, Borrelia burgdorferi.Q40520299
A single recombinant plasmid expressing two major outer surface proteins of the Lyme disease spirocheteQ41391064
Molecular analysis and expression of a Borrelia burgdorferi gene encoding a 22 kDa protein (pC) in Escherichia coliQ42119092
Analysis of the RpoS regulon in Borrelia burgdorferi in response to mammalian host signals provides insight into RpoS function during the enzootic cycleQ42392366
Borrelia burgdorferi oxidative stress regulator BosR directly represses lipoproteins primarily expressed in the tick during mammalian infection.Q42614910
Genome reduction of Borrelia burgdorferi: two TCS signaling pathways for two distinct host habitatsQ46614204
Expression of outer surface proteins A and C of Borrelia afzelii in Ixodes ricinus ticks and in the skin of miceQ47932162
Borrelia burgdorferi sensu stricto invasiveness is correlated with OspC-plasminogen affinity.Q50740824
Artificial regulation of ospC expression in Borrelia burgdorferi.Q51080046
Transcriptional interplay among the regulators Rrp2, RpoN and RpoS in Borrelia burgdorferi.Q54517987
Spirochetes Isolated from the Blood of Two Patients with Lyme DiseaseQ58402757
The Spirochetal Etiology of Lyme DiseaseQ58402764
Interdependence of environmental factors influencing reciprocal patterns of gene expression in virulent Borrelia burgdorferiQ74347225
Complementation of a Borrelia afzelii OspC mutant highlights the crucial role of OspC for dissemination of Borrelia afzelii in Ixodes ricinusQ79699501
Temperature-induced regulation of RpoS by a small RNA in Borrelia burgdorferiQ80335083
BadR (BB0693) controls growth phase-dependent induction of rpoS and bosR in Borrelia burgdorferi via recognizing TAAAATAT motifsQ86053327
Delineating the requirement for the Borrelia burgdorferi virulence factor OspC in the mammalian hostQ34681258
The hybrid histidine kinase Hk1 is part of a two-component system that is essential for survival of Borrelia burgdorferi in feeding Ixodes scapularis ticksQ35139218
Synthesis of RpoS is dependent on a putative enhancer binding protein Rrp2 in Borrelia burgdorferiQ35165390
BosR functions as a repressor of the ospAB operon in Borrelia burgdorferiQ35291036
Characterization of the RelBbu Regulon in Borrelia burgdorferi Reveals Modulation of Glycerol Metabolism by (p)ppGppQ35562522
Borrelia burgdorferi alters its gene expression and antigenic profile in response to CO2 levelsQ35634802
Evidence that RpoS (sigmaS) in Borrelia burgdorferi is controlled directly by RpoN (sigma54/sigmaN).Q35759377
The Borrelia burgdorferi RelA/SpoT Homolog and Stringent Response Regulate Survival in the Tick Vector and Global Gene Expression during StarvationQ35775775
Cyclic di-GMP modulates gene expression in Lyme disease spirochetes at the tick-mammal interface to promote spirochete survival during the blood meal and tick-to-mammal transmissionQ35833844
Acetyl-Phosphate Is Not a Global Regulatory Bridge between Virulence and Central Metabolism in Borrelia burgdorferiQ35872637
OspC is potent plasminogen receptor on surface of Borrelia burgdorferi.Q35956516
The response regulator Rrp2 is essential for the expression of major membrane lipoproteins in Borrelia burgdorferiQ35978799
Insights into the complex regulation of rpoS in Borrelia burgdorferiQ35990803
The outer surface protein A of the spirochete Borrelia burgdorferi is a plasmin(ogen) receptorQ35993610
Two Different Virulence-Related Regulatory Pathways in Borrelia burgdorferi Are Directly Affected by Osmotic Fluxes in the Blood Meal of Feeding Ixodes TicksQ36104097
Structural characterization and modeling of the Borrelia burgdorferi hybrid histidine kinase Hk1 periplasmic sensor: A system for sensing small molecules associated with tick feedingQ36160509
Borrelia oxidative stress response regulator, BosR: a distinctive Zn-dependent transcriptional activatorQ36161498
The role of Borrelia burgdorferi outer surface proteinsQ36179733
Recent functional insights into the role of (p)ppGpp in bacterial physiologyQ36319374
Direct demonstration of antigenic substitution of Borrelia burgdorferi ex vivo: exploration of the paradox of the early immune response to outer surface proteins A and C in Lyme diseaseQ36366179
An immune evasion mechanism for spirochetal persistence in Lyme borreliosisQ36369900
Molecular adaptation of Borrelia burgdorferi in the murine hostQ36370802
Essential role for OspA/B in the life cycle of the Lyme disease spirocheteQ36403858
Dissolved oxygen levels alter gene expression and antigen profiles in Borrelia burgdorferiQ36576855
Borrelia burgdorferi and tick proteins supporting pathogen persistence in the vectorQ36588072
The Fur homologue BosR requires Arg39 to activate rpoS transcription in Borrelia burgdorferi and thereby direct spirochaete infection in miceQ36725578
Borrelia host adaptation Regulator (BadR) regulates rpoS to modulate host adaptation and virulence factors in Borrelia burgdorferi.Q36789833
Essential role of the response regulator Rrp2 in the infectious cycle of Borrelia burgdorferiQ36845190
Outer surface protein A protects Lyme disease spirochetes from acquired host immunity in the tick vectorQ36949994
Manganese and zinc regulate virulence determinants in Borrelia burgdorferiQ37036059
Lyme disease spirochetes and ixodid tick spirochetes share a common surface antigenic determinant defined by a monoclonal antibodyQ37108001
Borrelia burgdorferi bba74 is expressed exclusively during tick feeding and is regulated by both arthropod- and mammalian host-specific signalsQ37157095
Evidence that BosR (BB0647) Is a Positive Autoregulator in Borrelia burgdorferiQ37199910
Induction of an outer surface protein on Borrelia burgdorferi during tick feedingQ24564198
Analysis of the Borrelia burgdorferi cyclic-di-GMP-binding protein PlzA reveals a role in motility and virulenceQ24600004
OspC facilitates Borrelia burgdorferi invasion of Ixodes scapularis salivary glandsQ24614518
Outer-surface protein C of the Lyme disease spirochete: a protein induced in ticks for infection of mammalsQ24624698
Cyclic di-GMP: the first 25 years of a universal bacterial second messengerQ26850396
Borrelia burgdorferi requires the alternative sigma factor RpoS for dissemination within the vector during tick-to-mammal transmissionQ27347529
Stage-specific global alterations in the transcriptomes of Lyme disease spirochetes during tick feeding and following mammalian host adaptationQ27347664
Interaction of the Lyme disease spirochete with its tick vectorQ28070884
Microarray-Based Comparative Genomic and Transcriptome Analysis of Borrelia burgdorferiQ28075720
(p)ppGpp: still magical?Q28278758
TROSPA, an Ixodes scapularis receptor for Borrelia burgdorferiQ28292578
Role of acetyl-phosphate in activation of the Rrp2-RpoN-RpoS pathway in Borrelia burgdorferiQ28475520
Live imaging reveals a biphasic mode of dissemination of Borrelia burgdorferi within ticksQ30492103
The diguanylate cyclase, Rrp1, regulates critical steps in the enzootic cycle of the Lyme disease spirochetes.Q30501663
The BosR regulatory protein of Borrelia burgdorferi interfaces with the RpoS regulatory pathway and modulates both the oxidative stress response and pathogenic properties of the Lyme disease spirocheteQ33585831
Rrp1, a cyclic-di-GMP-producing response regulator, is an important regulator of Borrelia burgdorferi core cellular functionsQ33745332
BosR (BB0647) controls the RpoN-RpoS regulatory pathway and virulence expression in Borrelia burgdorferi by a novel DNA-binding mechanismQ33828588
Effects of environmental pH on membrane proteins in Borrelia burgdorferi.Q33876130
Borrelia burgdorferi sigma54 is required for mammalian infection and vector transmission but not for tick colonizationQ33935887
Borrelia burgdorferi rel is responsible for generation of guanosine-3'-diphosphate-5'-triphosphate and growth control.Q33946540
Expression of Borrelia burgdorferi OspC and DbpA is controlled by a RpoN-RpoS regulatory pathwayQ33948046
Cyclic di-GMP is essential for the survival of the lyme disease spirochete in ticksQ33954418
Borrelia burgdorferi requires glycerol for maximum fitness during the tick phase of the enzootic cycleQ33959174
Inhibition of Borrelia burgdorferi migration from the midgut to the salivary glands following feeding by ticks on OspC-immunized mice.Q34003131
Purification and characterization of Borrelia burgdorferi from feeding nymphal ticks (Ixodes scapularis)Q34007498
Alternate sigma factor RpoS is required for the in vivo-specific repression of Borrelia burgdorferi plasmid lp54-borne ospA and lp6.6 genesQ34124377
Identification and function of the RNA chaperone Hfq in the Lyme disease spirochete Borrelia burgdorferi.Q34238399
Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetesQ34245905
Genetics of Borrelia burgdorferiQ34299547
Temporal analysis of the antigenic composition of Borrelia burgdorferi during infection in rabbit skinQ34342409
Who is the BosR around here anyway?Q34422732
Characterization of the stringent response and rel(Bbu) expression in Borrelia burgdorferiQ34514091
Expression of spoT in Borrelia burgdorferi during serum starvationQ34580258
Antigenic and genetic heterogeneity of Borrelia burgdorferi populations transmitted by ticksQ34625361
P433issue3-4
P921main subjectLyme diseaseQ201989
P304page(s)205-212
P577publication date2016-01-01
P1433published inForum on Immunopathological Diseases and TherapeuticsQ23979172
P1476titleGene Regulation During the Enzootic Cycle of the Lyme Disease Spirochete.
P478volume7