Computational identification, characterization and validation of potential antigenic peptide vaccines from hrHPVs E6 proteins using immunoinformatics and computational systems biology approaches.

scientific article

Computational identification, characterization and validation of potential antigenic peptide vaccines from hrHPVs E6 proteins using immunoinformatics and computational systems biology approaches. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1371/JOURNAL.PONE.0196484
P8608Fatcat IDrelease_upn23c3wzvgbjpr5jdswuwm5se
P932PMC publication ID5929558
P698PubMed publication ID29715318

P50authorAbbas KhanQ88531862
P2093author name stringArif Ali
Muhammad Junaid
Dong-Qing Wei
Syed Shujait Ali
Aman Chandra Kaushik
Aamir Mehmood
P2860cites workA coarse-grained protein force field for folding and structure prediction.Q51911563
New and simple method to predict dosage of drugs obeying simple Michaelis-Menten elimination kinetics and to distinguish such kinetics from simple first order and from parallel Michaelis-Menten and first order kinetics.Q52431235
A semi-empirical method for prediction of antigenic determinants on protein antigensQ52466148
Targeting retinoblastoma protein for degradation by proteasomes.Q53631242
The role of the proteasome in generating cytotoxic T-cell epitopes: insights obtained from improved predictions of proteasomal cleavageQ56879701
Therapeutic human papillomavirus vaccines: current clinical trials and future directionsQ56937332
Role of HLA-A motifs in identification of potential CTL epitopes in human papillomavirus type 16 E6 and E7 proteinsQ71616385
The kinetic stability of MHC class II:peptide complexes is a key parameter that dictates immunodominanceQ80416551
Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genesQ24311045
The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53Q24317677
SCRATCH: a protein structure and structural feature prediction serverQ24812422
A systematic bioinformatics approach for selection of epitope-based vaccine targetsQ27481378
Reliable prediction of T-cell epitopes using neural networks with novel sequence representationsQ27485882
Epitope recognition by diverse antibodies suggests conformational convergence in an antibody responseQ27638003
Inference of macromolecular assemblies from crystalline stateQ27860457
UCSF Chimera--a visualization system for exploratory research and analysisQ27860666
Towards peptide vaccines against Zika virus: Immunoinformatics combined with molecular dynamics simulations to predict antigenic epitopes of Zika viral proteinsQ28119724
Papillomaviruses and cancer: from basic studies to clinical applicationQ29614745
Classification of papillomavirusesQ29618731
ElliPro: a new structure-based tool for the prediction of antibody epitopesQ30373719
New hydrophilicity scale derived from high-performance liquid chromatography peptide retention data: correlation of predicted surface residues with antigenicity and X-ray-derived accessible sitesQ30708262
PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory DataQ31026348
Solving and analyzing side-chain positioning problems using linear and integer programmingQ31128789
Next generation simulation tools: the Systems Biology Workbench and BioSPICE integrationQ33196105
Large-scale validation of methods for cytotoxic T-lymphocyte epitope predictionQ33304572
The contribution of vaccination to global health: past, present and futureQ33624593
Human papillomavirus type 16 DNA cooperates with activated ras in transforming primary cells.Q33929221
Classification of papillomaviruses (PVs) based on 189 PV types and proposal of taxonomic amendmentsQ34021545
Influence of protein flexibility and peptide conformation on reactivity of monoclonal anti-peptide antibodies with a protein alpha-helixQ34372807
Human papillomaviruses and their role in cervical cancerQ34477831
A consensus epitope prediction approach identifies the breadth of murine T(CD8+)-cell responses to vaccinia virusQ34536936
Genital human papillomavirus infectionQ35114105
Delivering on the promise: HPV vaccines and cervical cancerQ35697573
The CD8+ T-cell response to lymphocytic choriomeningitis virus involves the L antigen: uncovering new tricks for an old virusQ35857498
Mechanisms of human papillomavirus-induced oncogenesis.Q35915935
Computational methods for prediction of T-cell epitopes--a framework for modelling, testing, and applicationsQ35948335
Human papillomaviruses in the pathogenesis of anogenital cancerQ36413260
A novel genital human papillomavirus (HPV), HPV type 74, found in immunosuppressed patientsQ36536470
NetMHCpan-3.0; improved prediction of binding to MHC class I molecules integrating information from multiple receptor and peptide length datasetsQ36742441
FireDock: a web server for fast interaction refinement in molecular dockingQ36749421
Immortalization and altered differentiation of human keratinocytes in vitro by the E6 and E7 open reading frames of human papillomavirus type 18.Q36800223
The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytesQ36831207
Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptideQ36904908
Papillomavirus E6 and E7 proteins and their cellular targetsQ36992007
Rapid clearance of human papillomavirus and implications for clinical focus on persistent infectionsQ36994715
Influence of chromosomal integration on glucocorticoid-regulated transcription of growth-stimulating papillomavirus genes E6 and E7 in cervical carcinoma cellsQ37404835
HLA class I alleles are associated with peptide-binding repertoires of different size, affinity, and immunogenicityQ37414385
Penises not required: a systematic review of the potential for human papillomavirus horizontal transmission that is non-sexual or does not include penile penetrationQ38598413
Basic concepts in population modeling, simulation, and model-based drug development-part 2: introduction to pharmacokinetic modeling methods.Q40118820
The E6-E7 region of human papillomavirus type 18 is sufficient for transformation of NIH 3T3 and rat-1 cellsQ40141212
Routine Microsecond Molecular Dynamics Simulations with AMBER on GPUs. 2. Explicit Solvent Particle Mesh EwaldQ40291611
Immunoinformatics and its relevance to understanding human immune diseaseQ40426673
The biology of human papillomaviruses: from warts to cancer.Q40742717
A phase I trial of a human papillomavirus (HPV) peptide vaccine for women with high-grade cervical and vulvar intraepithelial neoplasia who are HPV 16 positive.Q40746658
Correlation of modified human papilloma virus early gene expression with altered growth properties in C4-1 cervical carcinoma cells.Q41335230
PEP-FOLD3: faster de novo structure prediction for linear peptides in solution and in complexQ41724271
Structure and transcription of human papillomavirus sequences in cervical carcinoma cellsQ41914039
HPV-16 E6 and E7 protein T cell epitopes prediction analysis based on distributions of HLA-A loci across populations: an in silico approachQ42270718
AlgPred: prediction of allergenic proteins and mapping of IgE epitopes.Q42552741
Mutation analysis of the cross-reactive epitopes of Japanese encephalitis virus envelope glycoprotein.Q42977764
FireDock: fast interaction refinement in molecular dockingQ47598103
Gapped sequence alignment using artificial neural networks: application to the MHC class I system.Q47601200
Taking geometry to its edge: fast unbound rigid (and hinge-bent) dockingQ47613348
Human papillomavirus type distribution in 30,848 invasive cervical cancers worldwide: Variation by geographical region, histological type and year of publicationQ47860026
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectcomputational biologyQ177005
systems biologyQ815297
P304page(s)e0196484
P577publication date2018-05-01
P1433published inPLOS OneQ564954
P1476titleComputational identification, characterization and validation of potential antigenic peptide vaccines from hrHPVs E6 proteins using immunoinformatics and computational systems biology approaches
P478volume13