| scholarly article | Q13442814 |
| P356 | DOI | 10.1074/JBC.M700857200 |
| P698 | PubMed publication ID | 17556368 |
| P2093 | author name string | Elizabeth Petri Henske | |
| Warren D Kruger | |||
| Emmanuelle Nicolas | |||
| Tiffiney R Hartman | |||
| Damir Khabibullin | |||
| Marjon van Slegtenhorst | |||
| P2860 | cites work | Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling | Q24306277 |
| Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling | Q24672005 | ||
| Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2 | Q28181376 | ||
| Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner | Q28184844 | ||
| Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins | Q28207283 | ||
| Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dubé syndrome | Q28219681 | ||
| Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb | Q28646935 | ||
| Growing roles for the mTOR pathway | Q29616212 | ||
| mTOR and cancer: insights into a complex relationship | Q29617779 | ||
| A 4-bp deletion in the Birt-Hogg-Dubé gene (FLCN) causes dominantly inherited spontaneous pneumothorax | Q33938690 | ||
| Germline BHD-mutation spectrum and phenotype analysis of a large cohort of families with Birt-Hogg-Dubé syndrome | Q33938826 | ||
| Rheb promotes cell growth as a component of the insulin/TOR signalling network | Q34199893 | ||
| Clinical and genetic studies of Birt-Hogg-Dubé syndrome. | Q35559819 | ||
| Point mutations in TOR confer Rheb-independent growth in fission yeast and nutrient-independent mammalian TOR signaling in mammalian cells | Q35652261 | ||
| A germ-line insertion in the Birt-Hogg-Dubé (BHD) gene gives rise to the Nihon rat model of inherited renal cancer | Q36604503 | ||
| Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast. | Q38305278 | ||
| Protein farnesylation is critical for maintaining normal cell morphology and canavanine resistance in Schizosaccharomyces pombe | Q41711565 | ||
| Opposite effects of tor1 and tor2 on nitrogen starvation responses in fission yeast | Q41760820 | ||
| Regulation of leucine uptake by tor1+ in Schizosaccharomyces pombe is sensitive to rapamycin | Q43275098 | ||
| Rheb is an essential regulator of S6K in controlling cell growth in Drosophila | Q44453753 | ||
| Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe | Q44725308 | ||
| Pas1, a G1 cyclin, regulates amino acid uptake and rescues a delay in G1 arrest in Tsc1 and Tsc2 mutants in Schizosaccharomyces pombe | Q46663595 | ||
| Fission yeast Tor2 links nitrogen signals to cell proliferation and acts downstream of the Rheb GTPase. | Q50918265 | ||
| Birt-Hogg-Dubé syndrome: a novel marker of kidney neoplasia. | Q55033345 | ||
| A mutation in the canine BHD gene is associated with hereditary multifocal renal cystadenocarcinoma and nodular dermatofibrosis in the German Shepherd dog. | Q55037822 | ||
| High frequency of somatic frameshift BHD gene mutations in Birt-Hogg-Dubé-associated renal tumors. | Q55040958 | ||
| P433 | issue | 34 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | tuberous sclerosis | Q1362721 |
| Schizosaccharomyces pombe | Q2236682 | ||
| methionine import across plasma membrane | Q22290697 | ||
| L-methionine import across plasma membrane | Q27303885 | ||
| regulation of L-methionine import across plasma membrane | Q27862561 | ||
| positive regulation of L-methionine import across plasma membrane | Q27862562 | ||
| negative regulation of L-methionine import across plasma membrane | Q27862570 | ||
| tuberous sclerosis 1 | Q55998494 | ||
| P304 | page(s) | 24583-24590 | |
| P577 | publication date | 2007-06-07 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | The Birt-Hogg-Dube and tuberous sclerosis complex homologs have opposing roles in amino acid homeostasis in Schizosaccharomyces pombe. | |
| P478 | volume | 282 |
| Q37208419 | Absence of the Birt-Hogg-Dubé gene product is associated with increased hypoxia-inducible factor transcriptional activity and a loss of metabolic flexibility |
| Q24654382 | BHD mutations, clinical and molecular genetic investigations of Birt-Hogg-Dubé syndrome: a new series of 50 families and a review of published reports |
| Q39427667 | Birt-Hogg-Dubé Syndrome: A Review of Dermatological Manifestations and Other Symptoms. |
| Q38073149 | Birt-Hogg-Dubé syndrome and the skin. |
| Q90324576 | Birt-Hogg-Dubé syndrome with simultaneous hyperplastic polyposis of the gastrointestinal tract: case report and review of the literature |
| Q35015888 | Birt-Hogg-Dubé syndrome: diagnosis and management |
| Q36799958 | Birt-Hogg-Dubé syndrome: from gene discovery to molecularly targeted therapies |
| Q36283086 | Clinical Features, Genetics and Potential Therapeutic Approaches for Birt-Hogg-Dubé Syndrome |
| Q57737839 | Constitutional FLCN mutations in patients with suspected Birt-Hogg-Dubé syndrome ascertained for non-cutaneous manifestations |
| Q24298712 | Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer |
| Q28587662 | Deficiency of FLCN in mouse kidney led to development of polycystic kidneys and renal neoplasia |
| Q36046404 | FLCN Maintains the Leucine Level in Lysosome to Stimulate mTORC1. |
| Q47712748 | FLCN: The causative gene for Birt-Hogg-Dubé syndrome |
| Q36544967 | Flcn-deficient renal cells are tumorigenic and sensitive to mTOR suppression |
| Q30578909 | Folliculin controls lung alveolar enlargement and epithelial cell survival through E-cadherin, LKB1, and AMPK. |
| Q24298493 | Folliculin interacts with p0071 (plakophilin-4) and deficiency is associated with disordered RhoA signalling, epithelial polarization and cytokinesis |
| Q33396563 | Folliculin mutations are not associated with severe COPD. |
| Q34582386 | Folliculin regulates cell-cell adhesion, AMPK, and mTORC1 in a cell-type-specific manner in lung-derived cells. |
| Q34471857 | Folliculin, the product of the Birt-Hogg-Dube tumor suppressor gene, interacts with the adherens junction protein p0071 to regulate cell-cell adhesion |
| Q51241419 | H255Y and K508R missense mutations in tumour suppressor folliculin (FLCN) promote kidney cell proliferation. |
| Q34846527 | Human folliculin delays cell cycle progression through late S and G2/M-phases: effect of phosphorylation and tumor associated mutations |
| Q24318494 | Interaction of folliculin (Birt-Hogg-Dubé gene product) with a novel Fnip1-like (FnipL/Fnip2) protein |
| Q28513499 | Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys |
| Q36832543 | Loss of Folliculin Disrupts Hematopoietic Stem Cell Quiescence and Homeostasis Resulting in Bone Marrow Failure |
| Q28595056 | Loss of the Birt-Hogg-Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcription |
| Q36435544 | Lst4, the yeast Fnip1/2 orthologue, is a DENN-family protein |
| Q37429054 | Molecular genetics and clinical features of Birt-Hogg-Dubé syndrome |
| Q36751634 | Multiple amino acid sensing inputs to mTORC1. |
| Q33861388 | Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein |
| Q35536837 | Pulmonary manifestations of Birt-Hogg-Dubé syndrome. |
| Q38701574 | Rag GTPase in amino acid signaling |
| Q37208207 | Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases |
| Q24317276 | Serine 62 is a phosphorylation site in folliculin, the Birt-Hogg-Dubé gene product |
| Q36477664 | The Birt-Hogg-Dubé tumor suppressor Folliculin negatively regulates ribosomal RNA synthesis |
| Q35602650 | The folliculin mutation database: an online database of mutations associated with Birt-Hogg-Dubé syndrome |
| Q37402791 | The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. |
| Q28590041 | The role of the Birt-Hogg-Dubé protein in mTOR activation and renal tumorigenesis |
| Q33728003 | Topical rapamycin as a treatment for fibrofolliculomas in Birt-Hogg-Dubé syndrome: a double-blind placebo-controlled randomized split-face trial |
| Q24329165 | Tumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-beta signaling |
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