The 3’UTRs of Myelin Basic Protein mRNAs Regulate Transport, Local Translation and Sensitivity to Neuronal Activity in Zebrafish.

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The 3’UTRs of Myelin Basic Protein mRNAs Regulate Transport, Local Translation and Sensitivity to Neuronal Activity in Zebrafish. is …
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P356DOI10.3389/FNMOL.2018.00185
P932PMC publication ID6006989
P698PubMed publication ID29946237

P50authorLisbeth S LaursenQ64681314
P2093author name stringKasper Kjaer-Sorensen
Jes Steengaard
Julie Torvund-Jensen
Liselotte B Askebjerg
P2860cites workTransport and localization elements in myelin basic protein mRNAQ24680415
Mutational analysis of a heterogeneous nuclear ribonucleoprotein A2 response element for RNA traffickingQ28115780
hnRNP A2 selectively binds the cytoplasmic transport sequence of myelin basic protein mRNAQ28565429
In neurons, activity-dependent association of dendritically transported mRNA transcripts with the transacting factor CBF-A is mediated by A2RE/RTS elementsQ28568736
Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendritesQ28569134
Ensembl 2016Q28603093
High-resolution in situ hybridization to whole-mount zebrafish embryosQ29617529
MyelStones: the executive roles of myelin basic protein in myelin assembly and destabilization in multiple sclerosisQ30009078
Structural polymorphism and multifunctionality of myelin basic proteinQ30157180
An integrin-contactin complex regulates CNS myelination by differential Fyn phosphorylationQ33597124
Interactions of noncanonical motifs with hnRNP A2 promote activity-dependent RNA transport in neurons.Q33663144
Visualization of dynamics of single endogenous mRNA labeled in live mouseQ33951228
Translation of myelin basic protein mRNA in oligodendrocytes is regulated by integrin activation and hnRNP-K.Q34637839
Heterogeneous nuclear ribonucleoprotein (hnRNP) E1 binds to hnRNP A2 and inhibits translation of A2 response element mRNAsQ34886236
Myelin basic protein-dependent plasma membrane reorganization in the formation of myelinQ35121164
Visualization of myelination in GFP-transgenic zebrafish.Q50577403
Transgenesis in zebrafish with the tol2 transposon system.Q50591662
Developmental regulation of myelin basic protein expression in mouse brainQ52282081
Regulation of L-type Ca++ currents and process morphology in white matter oligodendrocyte precursor cells by golli-myelin proteinsQ57446297
Neuronal activity promotes myelination via a cAMP pathwayQ57997682
Molecular genetic analysis of myelin-deficient mice: shiverer mutant mice show deletion in gene(s) coding for myelin basic proteinQ69381267
Central myelin in the mouse mutant shivererQ71440826
The active transport of myelin basic protein into the nucleus suggests a regulatory role in myelinationQ73309372
Translocation of myelin basic protein mRNA in oligodendrocytes requires microtubules and kinesinQ73986573
Transport and translation of MBP mRNA is regulated differently by distinct hnRNP proteinsQ87281080
Neuronal activity induces synaptic delivery of hnRNP A2/B1 by a BDNF-dependent mechanism in cultured hippocampal neuronsQ35305075
SncRNA715 Inhibits Schwann Cell Myelin Basic Protein SynthesisQ35758755
CNS myelin wrapping is driven by actin disassemblyQ35901012
Evolution of a neuroprotective function of central nervous system myelinQ36117106
Synthesis and incorporation of myelin polypeptides into CNS myelinQ36209387
Transport and localization of exogenous myelin basic protein mRNA microinjected into oligodendrocytesQ36233394
Control of local protein synthesis and initial events in myelination by action potentialsQ36350920
Kif1b is essential for mRNA localization in oligodendrocytes and development of myelinated axonsQ37242769
Myelin proteomics: molecular anatomy of an insulating sheathQ37378722
Temporal dynamics of myelination in the zebrafish spinal cordQ37689081
Myelination and support of axonal integrity by gliaQ37808620
Making myelin basic protein -from mRNA transport to localized translationQ38149863
Zebrafish as a model to investigate CNS myelinationQ38255026
Binding of an RNA trafficking response element to heterogeneous nuclear ribonucleoproteins A1 and A2.Q38307739
Activation of oligodendroglial Fyn kinase enhances translation of mRNAs transported in hnRNP A2-dependent RNA granulesQ38517679
Individual axons regulate the myelinating potential of single oligodendrocytes in vivoQ38536485
Insights into mechanisms of central nervous system myelination using zebrafishQ38562069
Reorganization of Lipid Diffusion by Myelin Basic Protein as Revealed by STED NanoscopyQ38765892
Regulation of cell proliferation by nucleocytoplasmic dynamics of postnatal and embryonic exon-II-containing MBP isoformsQ39045095
Myelin basic protein synthesis is regulated by small non-coding RNA 715.Q39323209
Accumulation of the four myelin basic proteins in mouse brain during developmentQ39511464
In cultured oligodendrocytes the A/B-type hnRNP CBF-A accompanies MBP mRNA bound to mRNA trafficking sequencesQ39630391
The microtubule-associated protein tumor overexpressed gene/cytoskeleton-associated protein 5 is necessary for myelin basic protein expression in oligodendrocytesQ40106785
Synaptic vesicle release regulates myelin sheath number of individual oligodendrocytes in vivo.Q40551466
Heterogeneous nuclear ribonucleoprotein (hnRNP) F is a novel component of oligodendroglial RNA transport granules contributing to regulation of myelin basic protein (MBP) synthesisQ40648347
Cellular mechanisms regulating activity-dependent release of native brain-derived neurotrophic factor from hippocampal neurons.Q44228549
Expression of a myelin basic protein gene in transgenic shiverer mice: correction of the dysmyelinating phenotype.Q44381714
Developmental abnormalities of myelin basic protein expression in fyn knock-out brain reveal a role of Fyn in posttranscriptional regulation.Q45140471
Phosphatidylinositol 4,5-bisphosphate-dependent interaction of myelin basic protein with the plasma membrane in oligodendroglial cells and its rapid perturbation by elevated calcium.Q46049783
Dynein/dynactin is necessary for anterograde transport of Mbp mRNA in oligodendrocytes and for myelination in vivoQ46550388
Characterization of myelination in the developing zebrafishQ47073528
Molecular evolution of myelin basic protein, an abundant structural myelin componentQ47074144
The RNA-Binding Protein hnRNP K Mediates the Effect of BDNF on Dendritic mRNA Metabolism and Regulates Synaptic NMDA Receptors in Hippocampal Neurons.Q47102431
A size barrier limits protein diffusion at the cell surface to generate lipid-rich myelin-membrane sheetsQ47357701
Conditional knockout of TOG results in CNS hypomyelinationQ48368275
Chromosomal mapping of mouse myelin basic protein gene and structure and transcription of the partially deleted gene in shiverer mutant miceQ48468687
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P921main subjectDanio rerioQ169444
P304page(s)185
P577publication date2018-06-12
P1433published inFrontiers in Molecular NeuroscienceQ27721913
P1476titleThe 3'UTRs of Myelin Basic Protein mRNAs Regulate Transport, Local Translation and Sensitivity to Neuronal Activity in Zebrafish
P478volume11

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