Removal of HIV DNA by CRISPR from Patient Blood Engrafts in Humanized Mice.

scientific article published on 19 June 2018

Removal of HIV DNA by CRISPR from Patient Blood Engrafts in Humanized Mice. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.OMTN.2018.05.021
P932PMC publication ID6011019
P698PubMed publication ID30195766

P50authorRafal KaminskiQ59688197
Kamel KhaliliQ87966397
Pietro MancusoQ103027524
P2093author name stringChen Chen
Fatah Kashanchi
Shohreh Amini
Tracy Fischer
Rahsan Sariyer
Pasquale Ferrante
Won-Bin Young
Ramona Bella
Jeffrey M. Jacobson
P2860cites workEffect of transcription peptide inhibitors on HIV-1 replicationQ39549994
In Vivo Excision of HIV-1 Provirus by saCas9 and Multiplex Single-Guide RNAs in Animal ModelsQ40263108
A Combinatorial CRISPR-Cas9 Attack on HIV-1 DNA Extinguishes All Infectious Provirus in Infected T Cell CulturesQ40410004
Excision of HIV-1 DNA by gene editing: a proof-of-concept in vivo studyQ40668686
Functional screening of guide RNAs targeting the regulatory and structural HIV-1 viral genome for a cure of AIDS.Q40829178
Use of the CRISPR/Cas9 system as an intracellular defense against HIV-1 infection in human cellsQ41265657
Getting the "Kill" into "Shock and Kill": Strategies to Eliminate Latent HIV.Q47555333
Non-obese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment.Q53454854
RNA-guided human genome engineering via Cas9Q24598394
Multiplex genome engineering using CRISPR/Cas systemsQ24609428
Ongoing Clinical Trials of Human Immunodeficiency Virus Latency-Reversing and Immunomodulatory AgentsQ28079455
Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapyQ29615993
RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection.Q34025414
Is the central nervous system a reservoir of HIV-1?Q34434339
Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirusQ34655645
Gene Editing Approaches against Viral Infections and Strategy to Prevent Occurrence of Viral EscapeQ36216276
Exosomes from HIV-1-infected Cells Stimulate Production of Pro-inflammatory Cytokines through Trans-activating Response (TAR) RNAQ36466170
Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and productionQ36547664
Elimination of HIV-1 Genomes from Human T-lymphoid Cells by CRISPR/Cas9 Gene EditingQ36650962
Persistent HIV-1 replication maintains the tissue reservoir during therapyQ36897321
Tissue reservoirs of HIVQ37055454
A combinational CRISPR/Cas9 gene-editing approach can halt HIV replication and prevent viral escape.Q38759997
CRISPR/Cas9-Derived Mutations Both Inhibit HIV-1 Replication and Accelerate Viral Escape.Q38779072
P407language of work or nameEnglishQ1860
P921main subjectCRISPRQ412563
drug discoveryQ1418791
molecular medicineQ3523816
P304page(s)275-282
P577publication date2018-06-19
P1433published inMolecular Therapy. Nucleic acidsQ27724110
P1476titleRemoval of HIV DNA by CRISPR from Patient Blood Engrafts in Humanized Mice.
P478volume12

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cites work (P2860)
Q90071246A Broad Application of CRISPR Cas9 in Infectious Diseases of Central Nervous System
Q103027539CRISPR based editing of SIV proviral DNA in ART treated non-human primates
Q59351019CRISPR-Cas Biology and Infectious Diseases Applications
Q90523078CRISPR-Cas9 Dual-gRNA Attack Causes Mutation, Excision and Inversion of the HIV-1 Proviral DNA
Q60954918CRISPR/Cas9 Genome Editing to Disable the Latent HIV-1 Provirus
Q101476290CRISPR/Cas9 as an antiviral against Orthopoxviruses using an AAV vector
Q64073285CRISPR/Cas9-Based Antiviral Strategy: Current Status and the Potential Challenge
Q99237752Designing Safer CRISPR/Cas9 Therapeutics for HIV: Defining Factors That Regulate and Technologies Used to Detect Off-Target Editing
Q92871298Elimination of infectious HIV DNA by CRISPR-Cas9
Q92177909Humanized Mouse Model of HIV-1 Latency with Enrichment of Latent Virus in PD-1+ and TIGIT+ CD4 T Cells
Q92134571Measuring the Success of HIV-1 Cure Strategies
Q89957160Pathways towards human immunodeficiency virus elimination
Q89659572Reduce and Control: A Combinatorial Strategy for Achieving Sustained HIV Remissions in the Absence of Antiretroviral Therapy
Q78878955Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice
Q92912382Strong In Vivo Inhibition of HIV-1 Replication by Nullbasic, a Tat Mutant
Q64100645The Impact of HIV-1 Genetic Diversity on CRISPR-Cas9 Antiviral Activity and Viral Escape
Q90152125The Potential Use of the CRISPR-Cas System for HIV-1 Gene Therapy

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