Engineering metabolic pathways in Amycolatopsis japonicum for the optimization of the precursor supply for heterologous brasilicardin congeners production.

scientific article published on 12 January 2018

Engineering metabolic pathways in Amycolatopsis japonicum for the optimization of the precursor supply for heterologous brasilicardin congeners production. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.SYNBIO.2017.12.005
P932PMC publication ID5884276
P698PubMed publication ID29911199

P50authorAndreas KulikQ51012053
P2093author name stringWolfgang Wohlleben
Evi Stegmann
Paul N Schwarz
Luisa Roller
P2860cites workTwo distinct pathways for essential metabolic precursors for isoprenoid biosynthesisQ27023526
BTS1 Encodes a Geranylgeranyl Diphosphate Synthase in Saccharomyces cerevisiaeQ27936313
Isopentenyl diphosphate:dimethylallyl diphosphate isomerase. An improved purification of the enzyme and isolation of the gene from Saccharomyces cerevisiaeQ27938361
The discovery of a mevalonate-independent pathway for isoprenoid biosynthesis in bacteria, algae and higher plantsQ28139438
n-Butanol production in Saccharomyces cerevisiae is limited by the availability of coenzyme A and cytosolic acetyl-CoAQ28603844
Development of three different gene cloning systems for genetic investigation of the new species Amycolatopsis japonicum MG417-CF17, the ethylenediaminedisuccinic acid producerQ30663018
Precursor supply for polyketide biosynthesis: the role of crotonyl-CoA reductaseQ31853504
Kinetic and spectroscopic characterization of type II isopentenyl diphosphate isomerase from Thermus thermophilus: evidence for formation of substrate-induced flavin speciesQ34653826
Artemisinin-based combination treatment of falciparum malaria.Q34731529
Microbially derived artemisinin: a biotechnology solution to the global problem of access to affordable antimalarial drugsQ34731542
Biogenesis, molecular regulation and function of plant isoprenoidsQ36313537
Expression of an exogenous isopentenyl diphosphate isomerase gene enhances isoprenoid biosynthesis in Escherichia coliQ36865280
Feedback inhibition of deoxy-D-xylulose-5-phosphate synthase regulates the methylerythritol 4-phosphate pathwayQ36910185
Terpene biosynthesis: modularity rulesQ37162126
Biosynthesis of plant isoprenoids: perspectives for microbial engineering.Q37539962
Isoprenoid biosynthesis in bacterial pathogensQ37998851
Isopentenyl diphosphate isomerase: A checkpoint to isoprenoid biosynthesis.Q38002648
Metabolic engineering of volatile isoprenoids in plants and microbesQ38192718
A microbial platform for renewable propane synthesis based on a fermentative butanol pathway.Q38390790
Progress in terpene synthesis strategies through engineering of Saccharomyces cerevisiaeQ38828293
Strategies of isoprenoids production in engineered bacteriaQ38900531
Biosynthetic studies on terpenoids produced by StreptomycesQ39135500
Opportunities and challenges for the sustainable production of structurally complex diterpenoids in recombinant microbial systemsQ39331667
Engineering microbial cell factories for the production of plant natural products: from design principles to industrial-scale productionQ39445763
Evidence that the extracytoplasmic function sigma factor sigmaE is required for normal cell wall structure in Streptomyces coelicolor A3(2).Q39547203
Brasilicardin A, a natural immunosuppressant, targets amino Acid transport system L.Q40206706
High-Quality Draft Genome Sequence of the Actinobacterium Nocardia terpenica IFM 0406, Producer of the Immunosuppressant Brasilicardins, Using Illumina and PacBio TechnologiesQ40408156
SAR studies of brasilicardin A for immunosuppressive and cytotoxic activities.Q40460908
The mechanism of action of cyclosporin A and FK506.Q41114675
Effects of acetoacetyl-CoA synthase expression on production of farnesene in Saccharomyces cerevisiaeQ42026549
2C-Methyl-d-erythritol 4-phosphate enhances and sustains cyclodiphosphate synthase IspF activityQ42127680
Isoprenoid biosynthesis in bacteria: a novel pathway for the early steps leading to isopentenyl diphosphateQ42815553
Overproduction of Ristomycin A by activation of a silent gene cluster in Amycolatopsis japonicum MG417-CF17.Q42932823
Complete genome sequence of the actinobacterium Amycolatopsis japonica MG417-CF17(T) (=DSM 44213T) producing (S,S)-N,N'-ethylenediaminedisuccinic acidQ43752066
Se-phenyl prop-2-eneselenoate: an ethylene equivalent for Diels-Alder reactionsQ44246209
A relationship between the mevalonate pathway and isoprenoid production in actinomycetes.Q44756144
Enzymatic and structural characterization of type II isopentenyl diphosphate isomerase from hyperthermophilic archaeon Thermococcus kodakaraensisQ46481197
Functional analysis of type 1 isopentenyl diphosphate isomerase from Halobacterium sp. NRC-1.Q46956462
Chain elongation in the isoprenoid biosynthetic pathway.Q47829717
Manipulation of the Precursor Supply in Yeast Significantly Enhances the Accumulation of Prenylated β-CarbolinesQ48213379
Cloning and analysis of the promoter region of the erythromycin resistance gene (ermE) of Streptomyces erythraeusQ48383564
The Immunosuppressant Brasilicardin: Determination of the Biosynthetic Gene Cluster in the Heterologous Host Amycolatopsis japonicumQ50088359
Synthesis and Bioactivity of a Brasilicardin A Analogue Featuring a Simplified Core.Q53631846
The mRNA for the 23S rRNA methylase encoded by the ermE gene of Saccharopolyspora erythraea is translated in the absence of a conventional ribosome-binding site.Q54192770
Promoter constructions for efficient secretion expression in Streptomyces lividans.Q54280919
Bio-isoprene production using exogenous MVA pathway and isoprene synthase in Escherichia coli.Q54347350
Purification and properties of geranylgeranyl-diphosphate synthase from bovine brainQ72108226
Novel Synthetic Approach to the 8,10-Dimethyl anti-syn-anti-Perhydrophenanthrene SkeletonQ73252287
Brasilicardin A, a new terpenoid antibiotic from pathogenic Nocardia brasiliensis: fermentation, isolation and biological activityQ74636871
Brasilicardin A. A Novel Tricyclic Metabolite with Potent Immunosuppressive Activity from Actinomycete NocardiabrasiliensisQ74838947
Brasilicardins B–D, new tricyclic terpernoids from actinomycete Nocardia brasiliensisQ78281886
P433issue1
P921main subjectmetabolic pathwayQ68685
P304page(s)56-63
P577publication date2018-01-12
P1433published inSynthetic and systems biotechnologyQ27727682
P1476titleEngineering metabolic pathways in Amycolatopsis japonicum for the optimization of the precursor supply for heterologous brasilicardin congeners production
P478volume3

Reverse relations

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