Tumor heterogeneity of gastric cancer: From the perspective of tumor-initiating cell.

scientific article

Tumor heterogeneity of gastric cancer: From the perspective of tumor-initiating cell. is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.3748/WJG.V24.I24.2567
P932PMC publication ID6021770
P698PubMed publication ID29962814

P2093author name stringMin Yan
Wei Xu
Wen-Tao Liu
Zheng-Gang Zhu
Jian-Peng Gao
P2860cites workABC transporters as multidrug resistance mechanisms and the development of chemosensitizers for their reversalQ21246014
The spatial distribution of LGR5+ cells correlates with gastric cancer progressionQ21560986
The trifunctional antibody catumaxomab for the treatment of malignant ascites due to epithelial cancer: Results of a prospective randomized phase II/III trialQ24629295
Mature chief cells are cryptic progenitors for metaplasia in the stomachQ24631089
Inhibition of Hedgehog signaling by direct binding of cyclopamine to SmoothenedQ24682703
Clonal evolution models of tumor heterogeneityQ26863470
Gastric cancer stem cells: a novel therapeutic targetQ27002840
Cancer stem cells--the current status of an old concept: literature review and clinical approachesQ27025165
Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion SequencingQ27860948
Cell-of-Origin of Cancer versus Cancer Stem Cells: Assays and InterpretationsQ28080701
Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cellQ28188430
CD44 in cancerQ28217782
Comprehensive molecular characterization of gastric adenocarcinomaQ28244985
Identification of selective inhibitors of cancer stem cells by high-throughput screeningQ28255115
A novel two mode-acting inhibitor of ABCG2-mediated multidrug transport and resistance in cancer chemotherapyQ28475529
Dynamic vs static ABCG2 inhibitors to sensitize drug resistant cancer cellsQ28476445
Cancer statistics, 2016Q29547383
Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitroQ29616198
Influence of tumour micro-environment heterogeneity on therapeutic responseQ29617534
Heterogeneity in cancer: cancer stem cells versus clonal evolutionQ29622839
Identifying and targeting cancer stem cells in the treatment of gastric cancerQ30238811
Mechanisms of field cancerization in the human stomach: the expansion and spread of mutated gastric stem cellsQ33317848
Tumor initiating potential of side population cells in human gastric cancer.Q33429081
Cancer-associated fibroblasts might sustain the stemness of scirrhous gastric cancer cells via transforming growth factor-β signalingQ39071833
Heterogeneity of tumor cells in terms of cancer-initiating cellsQ39132578
Intra-tumor heterogeneity from a cancer stem cell perspective.Q39139446
Aldehyde dehydrogenase high gastric cancer stem cells are resistant to chemotherapyQ39188768
Induction of tumor stem cell differentiation--novel strategy to overcome therapy resistance in gastric cancerQ39193995
The self-renewal signaling pathways utilized by gastric cancer stem cellsQ39221222
Spheroid body-forming cells in the human gastric cancer cell line MKN-45 possess cancer stem cell propertiesQ39228334
Coordinated expression of REG4 and aldehyde dehydrogenase 1 regulating tumourigenic capacity of diffuse-type gastric carcinoma-initiating cells is inhibited by TGF-β.Q39376769
Modulation of glucose metabolism by CD44 contributes to antioxidant status and drug resistance in cancer cells.Q39403553
Identification of cancer stem cells in vincristine preconditioned SGC7901 gastric cancer cell lineQ39474693
Identification of CD44+CD24+ gastric cancer stem cellsQ39481277
Role of ES cell-expressed Ras (ERas) in tumorigenicity of gastric cancerQ39690008
Epigenetic regulation of the embryonic oncogene ERas in gastric cancer cellsQ39793946
mTOR signal and hypoxia-inducible factor-1 alpha regulate CD133 expression in cancer cellsQ39802014
Identification of gastric cancer stem cells using the cell surface marker CD44.Q39856772
Objective analysis of cancer stem cell marker expression using immunohistochemistryQ40425588
Characterization of Biomarkers of Tumorigenic and Chemoresistant Cancer Stem Cells in Human Gastric CarcinomaQ40543081
ICG-001 suppresses growth of gastric cancer cells and reduces chemoresistance of cancer stem cell-like populationQ41273119
Helicobacter pylori-induced epithelial-mesenchymal transition, a potential role of gastric cancer initiation and an emergence of stem cellsQ41417680
Acquired resistance to the Hedgehog pathway inhibitor vismodegib due to smoothened mutations in treatment of locally advanced basal cell carcinoma.Q42465206
Survival advantage for irinotecan versus best supportive care as second-line chemotherapy in gastric cancer--a randomised phase III study of the Arbeitsgemeinschaft Internistische Onkologie (AIO).Q42608504
Tumor heterogeneity, clonal evolution, and therapy resistance: an opportunity for multitargeting therapyQ42722265
Helicobacter pylori: Bone-marrow-derived cells could cause gastric preneoplasia in chronic Helicobacter pylori infectionQ43533331
Rilotumumab exposure-response relationship in patients with advanced or metastatic gastric cancerQ46084784
Dose-escalation study for the targeting of CD44v+ cancer stem cells by sulfasalazine in patients with advanced gastric cancer (EPOC1205).Q46567504
LGR5-Targeted Antibody-Drug Conjugate Eradicates Gastrointestinal Tumors and Prevents RecurrenceQ38769502
Helicobacter pylori upregulates Nanog and Oct4 via Wnt/β-catenin signaling pathway to promote cancer stem cell-like properties in human gastric cancerQ38789123
CD90 a potential cancer stem cell marker and a therapeutic targetQ38803617
Wnt/β-catenin signaling plays an ever-expanding role in stem cell self-renewal, tumorigenesis and cancer chemoresistance.Q38807957
Lgr5-Positive Cells are Cancer-Stem-Cell-Like Cells in Gastric CancerQ38843205
miR-106b modulates cancer stem cell characteristics through TGF-β/Smad signaling in CD44-positive gastric cancer cellsQ38950242
Macrophage-derived reactive oxygen species suppress miR-328 targeting CD44 in cancer cells and promote redox adaptationQ39045264
Notch as a Driver of Gastric Epithelial Cell ProliferationQ33600442
Epstein-Barr virus-associated gastric cancer reveals intratumoral heterogeneity of PIK3CA mutationsQ33608197
Roles of Wnt/β-catenin signaling in the gastric cancer stem cells proliferation and salinomycin treatmentQ33695152
Isolation of cancer progenitor cells from cancer stem cells in gastric cancerQ33702282
Initiation and Maintenance of Gastric Cancer: A Focus on CD44 Variant Isoforms and Cancer Stem CellsQ33711746
Sonic hedgehog pathway is essential for maintenance of cancer stem-like cells in human gastric cancerQ33843343
CD44 expression denotes a subpopulation of gastric cancer cells in which Hedgehog signaling promotes chemotherapy resistanceQ34055274
Context, tissue plasticity, and cancer: are tumor stem cells also regulated by the microenvironment?Q34103451
Epigenetic states of cells of origin and tumor evolution drive tumor-initiating cell phenotype and tumor heterogeneityQ34135305
Tumor-initiating cells are rare in many human tumorsQ34156000
Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth.Q34164197
Not all side population cells contain cancer stem-like cells in human gastric cancer cell linesQ34373503
Evolution of the cancer stem cell modelQ34408981
Cancer stem cell plasticity and tumor hierarchyQ34459650
Regulation of NANOG in cancer cellsQ34478004
Inhibition of gastric carcinogenesis by the hormone gastrin is mediated by suppression of TFF1 epigenetic silencing.Q34629266
Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesisQ34688350
Generation of pluripotent stem cells from adult mouse liver and stomach cellsQ34750323
Cancer Stem Cell Markers CD44, CD133 in Primary Gastric AdenocarcinomaQ34948623
Bone marrow-derived cells may not be the original cells for carcinogen-induced mouse gastrointestinal carcinomasQ35048576
5-Fluorouracil chemotherapy of gastric cancer generates residual cells with properties of cancer stem cellsQ35069199
Treatment of gastric peritoneal carcinomatosis by combining complete surgical resection of lesions and intraperitoneal immunotherapy using catumaxomabQ35109585
Stem cells and gastric cancer: role of gastric and intestinal mixed intestinal metaplasia.Q35112119
Signal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship?.Q35120899
Breast cancer stem cells, cytokine networks, and the tumor microenvironmentQ35571904
ATOH1 Can Regulate the Tumorigenicity of Gastric Cancer Cells by Inducing the Differentiation of Cancer Stem CellsQ35581773
Surgically resected human tumors reveal the biological significance of the gastric cancer stem cell markers CD44 and CD26.Q35742283
Identification and expansion of cancer stem cells in tumor tissues and peripheral blood derived from gastric adenocarcinoma patientsQ35958829
The evolving concept of cancer and metastasis stem cellsQ36145729
Prognostic Value of Cancer Stem Cell Markers CD44 and ALDH1/2 in Gastric Cancer CasesQ47127455
A clinical trial protocol paper discussing the BRIGHTER studyQ47753559
Helicobacter pylori infection recruits bone marrow-derived cells that participate in gastric preneoplasia in mice.Q50508280
Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment.Q51928042
Integrated analysis of cancer-related pathways affected by genetic and epigenetic alterations in gastric cancer.Q53067336
Carcinogenesis in mouse stomach by simultaneous activation of the Wnt signaling and prostaglandin E2 pathway.Q53341224
Salvage chemotherapy for pretreated gastric cancer: a randomized phase III trial comparing chemotherapy plus best supportive care with best supportive care alone.Q53384216
Intratumoral heterogeneity in gastric cancer: a new challenge to face.Q53385547
Trastuzumab (herceptin) targets gastric cancer stem cells characterized by CD90 phenotype.Q54360289
Epithelial stem cell repertoire in the gut: clues to the origin of cell lineages, proliferative units and cancerQ73670201
Gastric cancer originating from bone marrow-derived cellsQ81067451
Increased expression of sonic hedgehog and altered methylation of its promoter region in gastric cancer and its related lesionsQ82782824
Cancer spheres from gastric cancer patients provide an ideal model system for cancer stem cell researchQ83745627
Salinomycin can effectively kill ALDH(high) stem-like cells on gastric cancerQ85090123
Cancer stem cells: the challenges aheadQ86523719
Expanding the Lauren classification: a new gastric cancer subtype?Q87156198
CD44v8-10 is a cancer-specific marker for gastric cancer stem cellsQ87423294
Side population cells isolated from KATO III human gastric cancer cell line have cancer stem cell-like characteristicsQ36214625
Disruption of Klf4 in villin-positive gastric progenitor cells promotes formation and progression of tumors of the antrum in miceQ36336785
Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche.Q36386294
CDX1 confers intestinal phenotype on gastric epithelial cells via induction of stemness-associated reprogramming factors SALL4 and KLF5.Q36483451
Expression of stem cell markers nanog and PSCA in gastric cancer and its significanceQ36502900
Prospective identification of a multilineage progenitor in murine stomach epitheliumQ36579048
Mechanisms of chemoresistance in cancer stem cellsQ36591484
Tumor Heterogeneity--A 'Contemporary Concept' Founded on Historical Insights and PredictionsQ36636235
Sox2 enhances the tumorigenicity and chemoresistance of cancer stem-like cells derived from gastric cancerQ36732896
Targeted therapy for cancer stem cells: the patched pathway and ABC transportersQ36745386
Identification of stem-like cells and clinical significance of candidate stem cell markers in gastric cancerQ36962804
Gastric cancer stem cellsQ37186444
Crosstalk between bone marrow-derived myofibroblasts and gastric cancer cells regulates cancer stemness and promotes tumorigenesisQ37338336
Aldehyde dehydrogenases in cancer stem cells: potential as therapeutic targetsQ37583804
Epigenetics in cancer stem cellsQ37618640
Potential for therapeutic targeting of tumor stem cellsQ37622478
Deletion of IQGAP1 promotes Helicobacter pylori-induced gastric dysplasia in mice and acquisition of cancer stem cell properties in vitroQ37684660
The promotion of the transformation of quiescent gastric cancer stem cells by IL-17 and the underlying mechanismsQ37685452
HIF-1α induces the epithelial-mesenchymal transition in gastric cancer stem cells through the Snail pathwayQ37706009
Sonic hedgehog pathway contributes to gastric cancer cell growth and proliferationQ37715796
Gastric carcinogenesis and the cancer stem cell hypothesisQ37725726
Hypoxia and hypoxia inducible factors in cancer stem cell maintenanceQ37768064
Gastric cancer stem cells: therapeutic targets.Q38096903
CD44 integrates signaling in normal stem cell, cancer stem cell and (pre)metastatic nichesQ38100108
The cancer stem cell niche: cross talk between cancer stem cells and their microenvironmentQ38178133
Gastric cancer stem cells in gastric carcinogenesis, progression, prevention and treatmentQ38212216
Development of gastric cancer and its preventionQ38224742
Effect of Fluorouracil, Leucovorin, and Oxaliplatin With or Without Onartuzumab in HER2-Negative, MET-Positive Gastroesophageal Adenocarcinoma: The METGastric Randomized Clinical TrialQ38383859
Identification of molecular subtypes of gastric cancer with different responses to PI3-kinase inhibitors and 5-fluorouracilQ38490073
Mechanisms of Resistance to Chemotherapy in Gastric Cancer.Q38559156
Heterogeneity in Gastric Cancer: From Pure Morphology to Molecular ClassificationsQ38723978
miR‑483‑5p promotes growth, invasion and self‑renewal of gastric cancer stem cells by Wnt/β‑catenin signalingQ38752593
Clonal Heterogeneity and Tumor Evolution: Past, Present, and the FutureQ38758819
P275copyright licenseCreative Commons Attribution-NonCommercial 4.0 InternationalQ34179348
P433issue24
P407language of work or nameEnglishQ1860
P921main subjectcarcinogenesisQ1637543
neoplastic stem cellsQ1638475
tumor microenvironmentQ1786433
stomach neoplasmQ4335552
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)2567-2581
P577publication date2018-06-01
2018-06-28
P1433published inWorld Journal of GastroenterologyQ15708885
P1476titleTumor heterogeneity of gastric cancer: From the perspective of tumor-initiating cell
P478volume24

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cites work (P2860)
Q92343509Adapting and Surviving: Intra and Extra-Cellular Remodeling in Drug-Resistant Gastric Cancer Cells
Q89928216Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data
Q64990427Mast Cells, Angiogenesis and Lymphangiogenesis in Human Gastric Cancer.
Q64951606The Role of MicroRNAs in the Regulation of Gastric Cancer Stem Cells: A Meta-Analysis of the Current Status.
Q93012980VGLL3 is a prognostic biomarker and correlated with clinical pathologic features and immune infiltrates in stomach adenocarcinoma

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