DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis.

scientific article

DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis. is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2018NatCo...9.2397K
P6179Dimensions Publication ID1104585023
P356DOI10.1038/S41467-018-04732-5
P932PMC publication ID6008330
P698PubMed publication ID29921915

P50authorKári StefánssonQ6453246
Carsten Oliver SchmidtQ20748664
Frauke ZippQ21259942
Heinz WiendlQ27583547
Sigurgeir OlafssonQ88246221
Ewoud EwingQ88377522
Hannes P EggertssonQ89067127
Elisabeth Gulowsen CeliusQ89585276
Bernhard HemmerQ89705523
Hanne F HarboQ90089338
Maja JagodicQ90585165
Tomas J EkströmQ91345092
Lara KularQ91863056
Ralf GoldQ99630149
Tomas OlssonQ100512112
Annette B OturaiQ114403567
Helle Bach SøndergaardQ114403573
Sabrina RuhrmannQ114529274
Tojo JamesQ114529279
Shahin AeinehbandQ114529283
Haukur HjaltasonQ117242197
Tim KacprowskiQ37634569
Andre FrankeQ67470670
Jenny LinkQ55314033
Magdalena LindénQ55446213
Ingrid KockumQ55446225
Till F.M. AndlauerQ56356067
Fredrik PiehlQ56956300
Alexander DiltheyQ57451433
David Gomez-CabreroQ40263865
Yun LiuQ41882741
Francesco MarabitaQ42830707
Andrew P. FeinbergQ47421545
Bjarni V. HalldórssonQ47502536
Björn TackenbergQ48239917
Pernilla StridhQ48590093
P2093author name stringMatthias Laudes
Jesper Tegnér
Konstantin Strauch
Frank Weber
Ingileif Jonsdottir
Rajesh Rawal
Ulf Schminke
Bartosz Górnikiewicz
Christiane Gasperi
Stefanie Heilmann-Heimbach
Elias Olafsson
Galina Zheleznyakova
P2860cites workThe insulator factor CTCF controls MHC class II gene expression and is required for the formation of long-distance chromatin interactionsQ24312117
Mapping multiple sclerosis susceptibility to the HLA-DR locus in African AmericansQ24533132
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosisQ24635370
PLINK: a tool set for whole-genome association and population-based linkage analysesQ24677407
Principal components analysis corrects for stratification in genome-wide association studiesQ27860975
CTCF-promoted RNA polymerase II pausing links DNA methylation to splicingQ28249503
Genetic and epigenetic fine mapping of causal autoimmune disease variantsQ28649603
Multiple sclerosis risk variant HLA-DRB1*1501 associates with high expression of DRB1 gene in different human populationsQ28732826
Disentangling molecular relationships with a causal inference testQ28742231
[DHS: The Dortmund health study]Q84465416
Development of monocytes, macrophages, and dendritic cellsQ29616446
limma powers differential expression analyses for RNA-sequencing and microarray studiesQ29617988
Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responsesQ30504688
DNA methylation arrays as surrogate measures of cell mixture distributionQ30530775
Modelling genetic susceptibility to multiple sclerosis with family data.Q30573802
Differential roles of microglia and monocytes in the inflamed central nervous systemQ30585165
An extension to a statistical approach for family based association studies provides insights into genetic risk factors for multiple sclerosis in the HLA-DRB1 geneQ33405616
Transcription of angiogenin and ribonuclease 4 is regulated by RNA polymerase III elements and a CCCTC binding factor (CTCF)-dependent intragenic chromatin loopQ33556144
Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarraysQ33593399
Gene-specific repression of the p53 target gene PUMA via intragenic CTCF-Cohesin binding.Q33839575
Autonomous role of medullary thymic epithelial cells in central CD4(+) T cell toleranceQ34112986
Genome-wide associations between genetic and epigenetic variation influence mRNA expression and insulin secretion in human pancreatic isletsQ34464568
Large-scale whole-genome sequencing of the Icelandic populationQ34468572
Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritisQ34555143
Multi-population classical HLA type imputationQ34607788
Detection of sharing by descent, long-range phasing and haplotype imputationQ34928818
Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20.Q34986752
Genetic variation of ESR1 and its co-activator PPARGC1B is synergistic in augmenting the risk of estrogen receptor-positive breast cancerQ35029543
Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US childrenQ35120318
Genome-wide DNA methylation profiles indicate CD8+ T cell hypermethylation in multiple sclerosisQ35143918
IL-6 blockade by monoclonal antibodies inhibits apolipoprotein (a) expression and lipoprotein (a) synthesis in humansQ35536380
Filter-free exhaustive odds ratio-based genome-wide interaction approach pinpoints evidence for interaction in the HLA region in psoriasisQ35555915
The sva package for removing batch effects and other unwanted variation in high-throughput experimentsQ35838453
Layered genetic control of DNA methylation and gene expression: a locus of multiple sclerosis in healthy individualsQ36089373
KORA--a research platform for population based health researchQ36201201
Differential expression of major histocompatibility complex class II genes on murine macrophages associated with T cell cytokine profile and protective/suppressive effects.Q36500075
TET-catalyzed oxidation of intragenic 5-methylcytosine regulates CTCF-dependent alternative splicingQ36543721
Mechanisms and Disease Associations of Haplotype-Dependent Allele-Specific DNA MethylationQ36891490
Class II HLA interactions modulate genetic risk for multiple sclerosisQ36920509
Novel multiple sclerosis susceptibility loci implicated in epigenetic regulationQ37056269
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosisQ37322100
Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune CellsQ37429886
Epigenome-wide differences in pathology-free regions of multiple sclerosis-affected brainsQ37602769
High Incidence of Spontaneous Disease in an HLA-DR15 and TCR Transgenic Multiple Sclerosis ModelQ57704203
HLA-DR typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours: an alternative to serological DR typing in clinical practice including donor-recipient matching in cadaveric transplantationQ67522337
Association of susceptibility to multiple sclerosis in Sweden with HLA class II DRB1 and DQB1 allelesQ72417150
The DRB1 Val86/Val86 genotype associates with multiple sclerosis in Australian patientsQ78104025
The interleukin 23 receptor gene in multiple sclerosis: a case-control studyQ80420894
Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool.Q50515193
The Swedish Twin Registry: establishment of a biobank and other recent developments.Q51302187
HLA-DRB1*15:01 and multiple sclerosis: a female association?Q51381791
A Swedish national post-marketing surveillance study of natalizumab treatment in multiple sclerosis.Q51517678
Expansion and preferential activation of the CD14(+)CD16(+) monocyte subset during multiple sclerosis.Q53099338
HL-A antigens and multiple sclerosis.Q53892212
Methylation differences at the HLA-DRB1 locus in CD4+ T-Cells are associated with multiple sclerosis.Q54443135
Common and Low-Frequency Genetic Variants in the PCSK9 Locus Influence Circulating PCSK9 LevelsQ57303401
Cohort Profile: The Study of Health in PomeraniaQ57429582
GeMes, clusters of DNA methylation under genetic control, can inform genetic and epigenetic analysis of diseaseQ37693372
The insulator protein CTCF represses transcription on binding to the (gt)(22)(ga)(15) microsatellite in intron 2 of the HLA-DRB1(*)0401 geneQ38309421
Function and information content of DNA methylationQ38319920
Epigenetic research in multiple sclerosis: progress, challenges, and opportunities.Q38654321
The search for the target antigens of multiple sclerosis, part 1: autoreactive CD4+ T lymphocytes as pathogenic effectors and therapeutic targetsQ38685035
Genome wide differences of gene expression associated with HLA-DRB1 genotype in multiple sclerosis: a pilot study.Q39454014
DNA methylation: bisulphite modification and analysis.Q39479194
DNA methylation dysregulates and silences the HLA-DQ locus by altering chromatin architectureQ39591021
Assessment of clinically silent atherosclerotic disease and established and novel risk factors for predicting myocardial infarction and cardiac death in healthy middle-aged subjects: rationale and design of the Heinz Nixdorf RECALL Study. Risk FactoQ39611593
Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regressionQ40862437
The multiple sclerosis- and narcolepsy-associated HLA class II haplotype includes the DRB5*0101 alleleQ41287692
An evaluation of analysis pipelines for DNA methylation profiling using the Illumina HumanMethylation450 BeadChip platformQ41313805
HIBAG--HLA genotype imputation with attribute bagging.Q42614757
Tobacco smoking, but not Swedish snuff use, increases the risk of multiple sclerosisQ43282863
Nicotine might have a protective effect in the etiology of multiple sclerosis.Q45954074
Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosisQ46889094
Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlationsQ47105714
Orienting the causal relationship between imprecisely measured traits using GWAS summary dataQ47142527
Impact of genetic risk loci for multiple sclerosis on expression of proximal genes in patientsQ47564983
Graphtyper enables population-scale genotyping using pangenome graphs.Q47637069
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that useslimmaQ112236343
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectDNA methylationQ874745
multiple sclerosisQ8277
P304page(s)2397
P577publication date2018-06-19
P1433published inNature CommunicationsQ573880
P1476titleDNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis
P478volume9

Reverse relations

cites work (P2860)
Q62924311Biochemical Differences in Cerebrospinal Fluid between Secondary Progressive and Relapsing⁻Remitting Multiple Sclerosis
Q64109660Combining evidence from four immune cell types identifies DNA methylation patterns that implicate functionally distinct pathways during Multiple Sclerosis progression
Q64064150DNA methylation signatures of monozygotic twins clinically discordant for multiple sclerosis
Q92725655Diagnostic Utility of Genome-wide DNA Methylation Testing in Genetically Unsolved Individuals with Suspected Hereditary Conditions
Q92492014Environmental and genetic risk factors for MS: an integrated review
Q89936636Evaluation of DNA Methylation Episignatures for Diagnosis and Phenotype Correlations in 42 Mendelian Neurodevelopmental Disorders
Q92476184Frameshift mutations at the C-terminus of HIST1H1E result in a specific DNA hypomethylation signature
Q64083696Gene domain-specific DNA methylation episignatures highlight distinct molecular entities of ADNP syndrome
Q91345098Genotype-dependent epigenetic regulation of DLGAP2 in alcohol use and dependence
Q102144616Inferring Multiple Sclerosis Stages from the Blood Transcriptome via Machine Learning
Q96304273Multiple Sclerosis: Lipids, Lymphocytes, and Vitamin D
Q64062056Quantitative proteomic analyses of CD4 and CD8 T cells reveal differentially expressed proteins in multiple sclerosis patients and healthy controls
Q61818118The Interaction between Viral and Environmental Risk Factors in the Pathogenesis of Multiple Sclerosis
Q90754651Transcribed B lymphocyte genes and multiple sclerosis risk genes are underrepresented in Epstein-Barr Virus hypomethylated regions
Q64109951pwrEWAS: a user-friendly tool for comprehensive power estimation for epigenome wide association studies (EWAS)

Search more.