Immune checkpoint inhibitors in urothelial cancer: recent updates and future outlook.

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Immune checkpoint inhibitors in urothelial cancer: recent updates and future outlook. is …
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scholarly articleQ13442814

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P356DOI10.2147/TCRM.S158753
P8608Fatcat IDrelease_mmqqre3n6bcmtol6kkszyvsdsi
P932PMC publication ID5993034
P698PubMed publication ID29892196

P2093author name stringPetros Grivas
Athanasios Papatsoris
Vadim S Koshkin
Moshe C Ornstein
Dharmesh Gopalakrishnan
P2860cites workClonality of tumor-infiltrating lymphocytes in human urinary bladder carcinomaQ73966320
Nivolumab Gets FDA Nod for Bladder CancerQ89244598
Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine productionQ24292957
Immune checkpoint inhibitors in clinical practice: update on management of immune-related toxicitiesQ26775383
CTLA-4 and PD-1 Pathways: Similarities, Differences, and Implications of Their InhibitionQ26777563
PembrolizumabQ26796435
PD-1 Blockade in Tumors with Mismatch-Repair DeficiencyQ28262647
The role of the CD28 receptor during T cell responses to antigenQ28263234
Comprehensive molecular characterization of urothelial bladder carcinomaQ28306864
Combined Nivolumab and Ipilimumab or Monotherapy in Untreated MelanomaQ29615443
Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancerQ29615679
Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patientsQ29617771
MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancerQ29617772
Genetic basis for clinical response to CTLA-4 blockade in melanomaQ29620594
Pembrolizumab for the treatment of non-small-cell lung cancerQ29620851
Safety profiles of anti-CTLA-4 and anti-PD-1 antibodies alone and in combinationQ30251438
Atezolizumab as first-line treatment in cisplatin-ineligible patients with locally advanced and metastatic urothelial carcinoma: a single-arm, multicentre, phase 2 trial.Q30275266
Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trialQ30277192
Management of immune checkpoint blockade dysimmune toxicities: a collaborative position paperQ31034415
Randomized phase II/III trial assessing gemcitabine/carboplatin and methotrexate/carboplatin/vinblastine in patients with advanced urothelial cancer who are unfit for cisplatin-based chemotherapy: EORTC study 30986Q33398722
Randomized phase III study comparing paclitaxel/cisplatin/gemcitabine and gemcitabine/cisplatin in patients with locally advanced or metastatic urothelial cancer without prior systemic therapy: EORTC Intergroup Study 30987.Q33399928
Nivolumab monotherapy in recurrent metastatic urothelial carcinoma (CheckMate 032): a multicentre, open-label, two-stage, multi-arm, phase 1/2 trialQ33435967
Molecular classification of urothelial carcinoma: global mRNA classification versus tumour-cell phenotype classificationQ33628683
FDA Approval Summary: Atezolizumab for the Treatment of Patients with Progressive Advanced Urothelial Carcinoma after Platinum-Containing ChemotherapyQ33793541
Preoperative CTLA-4 blockade: tolerability and immune monitoring in the setting of a presurgical clinical trialQ34058870
Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade.Q34557699
CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kineticsQ34738334
The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpointsQ34943776
Phase III trial of vinflunine plus best supportive care compared with best supportive care alone after a platinum-containing regimen in patients with advanced transitional cell carcinoma of the urothelial tractQ34997941
High prevalence of activated intraepithelial cytotoxic T lymphocytes and increased neoplastic cell apoptosis in colorectal carcinomas with microsatellite instabilityQ35787046
Rheumatic immune-related adverse events of checkpoint therapy for cancer: case series of a new nosological entityQ42204050
Durvalumab: First Global ApprovalQ42374913
Comprehensive Molecular Characterization of Muscle-Invasive Bladder CancerQ42516513
Clostridium difficile infection may loom behind ipilimumab-induced auto-immune colitisQ44776446
Long-term survival results of a randomized trial comparing gemcitabine plus cisplatin, with methotrexate, vinblastine, doxorubicin, plus cisplatin in patients with bladder cancerQ46610841
Atezolizumab versus chemotherapy in patients with platinum-treated locally advanced or metastatic urothelial carcinoma (IMvigor211): a multicentre, open-label, phase 3 randomised controlled trialQ47264823
Anti-PD-L1/TGFβR2 (M7824) fusion protein induces immunogenic modulation of human urothelial carcinoma cell lines, rendering them more susceptible to immune-mediated recognition and lysisQ47440377
Anti-PD-1 and PD-L1 therapy for bladder cancer: what is on the horizon?Q48413956
Atezolizumab in platinum-treated locally advanced or metastatic urothelial carcinoma: post-progression outcomes from the phase II IMvigor210 studyQ49821320
Management of toxicities from immunotherapy: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-upQ50205173
Neurological, respiratory, musculoskeletal, cardiac and ocular side-effects of anti-PD-1 therapy.Q51532051
Low T-cell Receptor Diversity, High Somatic Mutation Burden, and High Neoantigen Load as Predictors of Clinical Outcome in Muscle-invasive Bladder Cancer.Q53103002
Neurological immune-related adverse events of ipilimumabQ56897418
Anti-CTLA-4 antibody-induced Guillain-Barré syndrome in a melanoma patientQ56898955
CTLA-4 (CD152) can inhibit T cell activation by two different mechanisms depending on its level of cell surface expressionQ56905906
Posterior Reversible Encephalopathy Syndrome During Ipilimumab Therapy for Malignant MelanomaQ60682608
Anti-PD-1-Related Pneumonitis during Cancer ImmunotherapyQ35965389
Endocrine-related adverse events following ipilimumab in patients with advanced melanoma: a comprehensive retrospective review from a single institutionQ36069247
Contribution of systemic and somatic factors to clinical response and resistance to PD-L1 blockade in urothelial cancer: An exploratory multi-omic analysis.Q36383913
Antibody-Dependent Cellular Cytotoxicity Activity of a Novel Anti-PD-L1 Antibody Avelumab (MSB0010718C) on Human Tumor CellsQ36539682
Heterogeneity of Programmed Cell Death Ligand 1 Expression in Multifocal Lung Cancer.Q36863349
Tremelimumab (CP-675,206), a cytotoxic T lymphocyte associated antigen 4 blocking monoclonal antibody in clinical development for patients with cancerQ36900726
A fully human IgG1 anti-PD-L1 MAb in an in vitro assay enhances antigen-specific T-cell responsesQ37010668
Bladder Cancer Molecular Taxonomy: Summary from a Consensus MeetingQ37053995
Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockadeQ37173548
Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoeditingQ37418530
Current Diagnosis and Management of Immune Related Adverse Events (irAEs) Induced by Immune Checkpoint Inhibitor TherapyQ37629874
Atypical neurological complications of ipilimumab therapy in patients with metastatic melanomaQ37641262
Clinical Development of the Anti–CTLA-4 Antibody TremelimumabQ37809151
Ipilimumab: a novel immunostimulatory monoclonal antibody for the treatment of cancer.Q37935254
Efficacy and Safety of Durvalumab in Locally Advanced or Metastatic Urothelial Carcinoma: Updated Results From a Phase 1/2 Open-label Study.Q38372019
Nivolumab: targeting PD-1 to bolster antitumor immunityQ38387311
Immunotherapy and hypophysitis: clinical presentation, treatment, and biologic insightsQ38549542
Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancerQ38663576
Immune-related adverse events with immune checkpoint blockade: a comprehensive reviewQ38696141
IFN-γ-related mRNA profile predicts clinical response to PD-1 blockade.Q38709131
Microsatellite Instability as a Biomarker for PD-1 BlockadeQ38735093
Avelumab for metastatic or locally advanced previously treated solid tumours (JAVELIN Solid Tumor): a phase 1a, multicohort, dose-escalation trialQ38735563
Emerging role of immunotherapy in urothelial carcinoma-Immunobiology/biomarkersQ38796338
Avelumab, an Anti-Programmed Death-Ligand 1 Antibody, In Patients With Refractory Metastatic Urothelial Carcinoma: Results From a Multicenter, Phase Ib StudyQ38855950
Programmed cell death-1 pathway inhibitors in genitourinary malignancies: specific side-effects and their managementQ38925832
Molecular and Biochemical Aspects of the PD-1 Checkpoint PathwayQ38996832
Cancer Statistics, 2017.Q39038674
Safety and activity of pembrolizumab in patients with locally advanced or metastatic urothelial cancer (KEYNOTE-012): a non-randomised, open-label, phase 1b studyQ39084242
Nivolumab in metastatic urothelial carcinoma after platinum therapy (CheckMate 275): a multicentre, single-arm, phase 2 trialQ39107888
Cutaneous adverse effects of the immune checkpoint inhibitorsQ39132344
Pulmonary Toxicities from Checkpoint Immunotherapy for MalignancyQ39287502
Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodiesQ39828440
Pneumonitis in Patients Treated With Anti-Programmed Death-1/Programmed Death Ligand 1 Therapy.Q40534742
Safety and Efficacy of Durvalumab (MEDI4736), an Anti-Programmed Cell Death Ligand-1 Immune Checkpoint Inhibitor, in Patients With Advanced Urothelial Bladder CancerQ40715310
Pembrolizumab as Second-Line Therapy for Advanced Urothelial Carcinoma.Q41979947
Molecular Drivers of the Non-T-cell-Inflamed Tumor Microenvironment in Urothelial Bladder CancerQ42176800
P275copyright licenseCreative Commons Attribution-NonCommercial 3.0 UnportedQ18810331
P6216copyright statuscopyrightedQ50423863
P304page(s)1019-1040
P577publication date2018-06-05
P1433published inTherapeutics and Clinical Risk ManagementQ15766913
P1476titleImmune checkpoint inhibitors in urothelial cancer: recent updates and future outlook.
P478volume14

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cites work (P2860)
Q61806668A review of avelumab in locally advanced and metastatic bladder cancer
Q96591113ARID1A mutation plus CXCL13 expression act as combinatorial biomarkers to predict responses to immune checkpoint therapy in mUCC
Q92128606Bladder cancer, a unique model to understand cancer immunity and develop immunotherapy approaches
Q92259183Consultation on UTUC, Stockholm 2018: aspects of treatment
Q92812554Emerging Roles of Cancer Stem Cells in Bladder Cancer Progression, Tumorigenesis, and Resistance to Chemotherapy: A Potential Therapeutic Target for Bladder Cancer
Q98213175Immunotherapy-based combination strategies for advanced urothelial cancer: A long quest
Q91912058Impact of performance status on treatment outcomes: A real-world study of advanced urothelial cancer treated with immune checkpoint inhibitors
Q91761153Mouse and human urothelial cancer organoids: A tool for bladder cancer research
Q89510215Targeting the Immune system and Epigenetic Landscape of Urological Tumors