SMAD4 Protein Expression Is Downregulated in Ileal Epithelial Cells from Patients with Crohn's Disease with Significant Inverse Correlation to Disease Activity.

scientific article

SMAD4 Protein Expression Is Downregulated in Ileal Epithelial Cells from Patients with Crohn's Disease with Significant Inverse Correlation to Disease Activity. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1155/2018/9307848
P932PMC publication ID5994270
P698PubMed publication ID29977289

P50authorPia KlausenQ74200543
P2093author name stringPeter Vilmann
Mehmet Coskun
Adrian Săftoiu
Lene Buhl Riis
John Gásdal Karstensen
Jack Bernard Cowland
P2860cites workCentral role of the gut epithelial barrier in the pathogenesis of chronic intestinal inflammation: lessons learned from animal models and human geneticsQ21131205
MicroRNA-34a regulates cardiac fibrosis after myocardial infarction by targeting Smad4Q28118775
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Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel diseaseQ30519492
SMAD4 mutations in colorectal cancer probably occur before chromosomal instability, but after divergence of the microsatellite instability pathwayQ33933528
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A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasionQ34192675
Functional screening for miRNAs targeting Smad4 identified miR-199a as a negative regulator of TGF-β signalling pathway.Q34347568
Confocal laser endomicroscopy: a novel method for prediction of relapse in Crohn's diseaseQ35846140
Phase I clinical trial of Smad7 knockdown using antisense oligonucleotide in patients with active Crohn's diseaseQ35876184
The clinical and biological significance of MIR-224 expression in colorectal cancer metastasisQ36090214
SMAD4 haploinsufficiency associates with augmented colonic inflammation in select humans and miceQ37419468
Development and validation of a new, simplified endoscopic activity score for Crohn's disease: the SES-CDQ80838195
Ubiquitin-mediated degradation a mechanism for fine-tuning TGF-beta signalingQ81632879
Chronic colitis induces expression of β-defensins in murine intestinal epithelial cellsQ82254050
Mongersen, an oral SMAD7 antisense oligonucleotide, and Crohn's diseaseQ86952010
Mucosal healing as a target of therapy for colonic inflammatory bowel disease and methods to score disease activityQ38224249
MicroRNA-130a-mediated down-regulation of Smad4 contributes to reduced sensitivity to TGF-β1 stimulation in granulocytic precursorsQ38330822
Expression of Toll-like receptor-3 is enhanced in active inflammatory bowel disease and mediates the excessive release of lipocalin 2.Q39152785
Spontaneous and cytokine induced expression and activity of matrix metalloproteinases in human colonic epitheliumQ39896496
TGF-beta/Smad signaling defects in inflammatory bowel disease: mechanisms and possible novel therapies for chronic inflammationQ39947013
Smad4 protein stability is regulated by ubiquitin ligase SCF beta-TrCP1.Q40584931
TGF-β1 Accelerates Wound Healing: Reversal of Steroid-Impaired Healing in Rats and RabbitsQ41147276
MicroRNA-26b functions as a proapoptotic factor in porcine follicular Granulosa cells by targeting Sma-and Mad-related protein 4.Q44784192
Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn's disease: an open randomised trialQ49167560
Transforming growth factor-beta1 and its receptors in patients with ulcerative colitis.Q51769741
Effects of Mongersen (GED-0301) on Endoscopic and Clinical Outcomes in Patients With Active Crohn's Disease.Q53093762
Smad4 signalling in T cells is required for suppression of gastrointestinal cancer.Q54462818
Expression of transforming growth factors alpha and beta in colonic mucosa in inflammatory bowel diseaseQ71035783
Early lesions of recurrent Crohn's disease caused by infusion of intestinal contents in excluded ileumQ74133428
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P304page(s)9307848
P577publication date2018-05-24
P1433published inGastroenterology research and practiceQ26853898
P1476titleSMAD4 Protein Expression Is Downregulated in Ileal Epithelial Cells from Patients with Crohn's Disease with Significant Inverse Correlation to Disease Activity
P478volume2018

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Q64233984Clinicopathological characterization of SMAD4-mutated intestinal adenocarcinomas: A case-control studycites workP2860

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