Elevated galanin receptor type 2 primarily contributes to mechanical hypersensitivity after median nerve injury.

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Elevated galanin receptor type 2 primarily contributes to mechanical hypersensitivity after median nerve injury. is …
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P356DOI10.1371/JOURNAL.PONE.0199512
P8608Fatcat IDrelease_gdgenv22wbhqlhxpgctwcvwhbe
P932PMC publication ID6013116
P698PubMed publication ID29928003

P50authorYi-Ju TsaiQ89177158
June-Horng LueQ59682076
P2093author name stringShu-Mei Lai
Chi-Te Lin
Hsin-Ying Wang
Seu-Hwa Chen
Ya-Chin Chen
Yung-Jung Hsiao
P2860cites workIn vivo and in vitro effects of peripheral galanin on nociceptive transmission in naive and neuropathic statesQ73080939
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Differential expression of galanin immunoreactivities in the primary sensory neurons following partial and complete sciatic nerve injuriesQ73503481
Nitric oxide synthase and growth-associated protein are coexpressed in primary sensory neurons after peripheral injuryQ77786671
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Activation of peripheral galanin receptors: differential effects on nociceptionQ80332152
Characterization of the induced neuropeptide Y-like immunoreactivity in primary sensory neurons following complete median nerve transectionQ80411031
Differential galanin upregulation in dorsal root ganglia and spinal cord after graded single ligature nerve constriction of the rat sciatic nerveQ80784177
Phenotyping of sensory and sympathetic ganglion neurons of a galanin-overexpressing mouse--possible implications for pain processingQ48613119
Somatotopic organization of the dorsal column nuclei in the rat: transganglionic labelling with B-HRP and WGA-HRPQ48625143
The synaptic interrelationships between primary afferent terminals, cuneothalamic relay neurons and GABA-immunoreactive boutons in the rat cuneate nucleus.Q49074072
Synaptic relationships between induced neuropeptide Y-like immunoreactive terminals and cuneothalamic projection neurons in the rat cuneate nucleus following median nerve transectionQ49120336
Nitric oxide mediates the thermal hyperalgesia produced in a model of neuropathic pain in the ratQ50790525
IDENTIFICATION OF RELAY CELLS AND INTERNEURONS IN THE CUNEATE NUCLEUSQ51268267
Dorsal hippocampal galanin modulates anxiety-like behaviours in rats.Q53442790
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Large calibre primary afferent neurons projecting to the gracile nucleus express neuropeptide Y after sciatic nerve lesions: an immunohistochemical and in situ hybridization study in ratsQ71606530
GABAergic boutons establish synaptic contacts with the soma and dendrites of cuneothalamic relay neurons in the rat cuneate nucleusQ71629737
Extra-territorial pain in rats with a peripheral mononeuropathy: mechano-hyperalgesia and mechano-allodynia in the territory of an uninjured nerveQ72744329
Ethical guidelines for investigations of experimental pain in conscious animalsQ29617510
The galanin-R2 agonist AR-M1896 reduces glutamate toxicity in primary neural hippocampal cellsQ33225947
Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via GalR1 and GalR2 receptorsQ33934812
Surgical management and outcomes in patients with median nerve lesionsQ34399052
Activation of the galanin receptor 2 in the periphery reverses nerve injury-induced allodynia.Q35003775
Pre-emptive treatment of lidocaine attenuates neuropathic pain and reduces pain-related biochemical markers in the rat cuneate nucleus in median nerve chronic constriction injury modelQ35581897
Galanin acts as a trophic factor to the central and peripheral nervous systemsQ37171935
Galanin and its receptor system promote the repair of injured sciatic nerves in diabetic rats.Q37387306
Expression and regulation of galanin-R2 receptors in rat primary sensory neurons: effect of axotomy and inflammation.Q38340342
Beneficial effects of neuropeptide galanin on reinstatement of exercise-induced somatic and psychological traumaQ38934052
Neurosteroid Allopregnanolone Suppresses Median Nerve Injury-induced Mechanical Hypersensitivity and Glial Extracellular Signal-regulated Kinase Activation through γ-Aminobutyric Acid Type A Receptor Modulation in the Rat Cuneate NucleusQ39166987
Pro-nociceptive role of peripheral galanin in inflammatory painQ39690737
Output systems of the dorsal column nuclei in the cat.Q39747728
Peripheral nerve injuries: an international survey of current treatments and future perspectivesQ39993726
Messenger plasticity in primary sensory neurons following axotomy and its functional implicationsQ40387628
Peripheral galanin receptor 2 as a target for the modulation of pain.Q40793648
Nerve growth factor induces P2X(3) expression in sensory neurons.Q40809049
Using c-fos as a neural marker of pain.Q41684857
Heterogeneous responses of dorsal root ganglion neurons in neuropathies induced by peripheral nerve trauma and the antiretroviral drug stavudineQ42919839
A beta-fiber intensity stimulation of chronically constricted median nerve induces c-fos expression in thalamic projection neurons of the cuneate nucleus in rats with behavioral signs of neuropathic painQ43548485
Lysophosphatidylcholine causes neuropathic pain via the increase of neuronal nitric oxide synthase in the dorsal root ganglion and cuneate nucleusQ43877620
Neuropathic pain is associated with alterations of nitric oxide synthase immunoreactivity and catalytic activity in dorsal root ganglia and spinal dorsal hornQ44070624
Changing pattern of c-FOS expression in spinal cord neurons after electrical stimulation of the chronically injured sciatic nerve in the rat.Q44288769
Nitric oxide implicates c-Fos expression in the cuneate nucleus following electrical stimulation of the transected median nerve.Q44812621
Neuropeptide expression in rat dorsal root ganglion cells and spinal cord after peripheral nerve injury with special reference to galaninQ45038370
Rho-kinase inhibition enhances axonal plasticity and attenuates cold hyperalgesia after dorsal rhizotomy.Q45170164
Regulation of galanin and galanin receptor 2 expression by capsaicin in primary cultured dorsal root ganglion neuronsQ46540787
Mechanism by which peripheral galanin increases acute inflammatory painQ46672020
Neuropeptide Y modulates c-Fos protein expression in the cuneate nucleus and contributes to mechanical hypersensitivity following rat median nerve injuryQ47761801
Inducible galanin and GalR2 receptor system in motor neuron injury and regeneration.Q47777625
A time course analysis of the changes in neuropeptide Y immunoreactivity in the rat cuneate nucleus following median nerve transection.Q47891764
Distribution of c-fos expressing dorsal horn neurons after electrical stimulation of low threshold sensory fibers in the chronically injured sciatic nerve.Q48138106
Lesion‐induced changes in the central terminal distribution of galanin‐immunoreactive axons in the dorsal column nucleiQ48266882
Changes in c-Fos protein expression in the rat cuneate nucleus after electric stimulation of the transected median nerveQ48507698
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)e0199512
P577publication date2018-06-21
P1433published inPLOS OneQ564954
P1476titleElevated galanin receptor type 2 primarily contributes to mechanical hypersensitivity after median nerve injury
P478volume13

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Q91970619The Median Nerve Injury Model in Pre-clinical Research - A Critical Review on Benefits and Limitationscites workP2860

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