Toll-like receptor triggered dendritic cell maturation and IL-12 secretion are necessary to overcome T-cell inhibition by glioma-associated TGF-beta2.

scientific article published on 15 November 2006

Toll-like receptor triggered dendritic cell maturation and IL-12 secretion are necessary to overcome T-cell inhibition by glioma-associated TGF-beta2. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1044272413
P356DOI10.1007/S11060-006-9274-2
P698PubMed publication ID17106649

P2093author name stringGosse J Adema
Ulrich Bogdahn
Oliver Grauer
Annette Lohmeier
Peter Pöschl
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A constitutive active MEK --> ERK pathway negatively regulates NF-kappa B-dependent gene expression by modulating TATA-binding protein phosphorylationQ40870326
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Broad expression of Toll-like receptors in the human central nervous systemQ44492400
TGF-beta attenuates the class II transactivator and reveals an accessory pathway of IFN-gamma action.Q44601976
TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and miceQ44714971
Induction of an antitumor immunological response by an intratumoral injection of dendritic cells pulsed with genetically engineered Semliki Forest virus to produce interleukin-18 combined with the systemic administration of interleukin-12Q45710750
Cutting edge: cross-presentation as a mechanism for efficient recruitment of tumor-specific CTL to the brain.Q48222103
A dendritic cell vaccine induces protective immunity to intracranial growth of glioma.Q48603942
Initiation of immune responses in brain is promoted by local dendritic cells.Q50796487
Phenotypical and functional characterization of clinical grade dendritic cells.Q52010684
Cutting edge: different Toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-Fos.Q52956682
Final maturation of dendritic cells is associated with impaired responsiveness to IFN-gamma and to bacterial IL-12 inducers: decreased ability of mature dendritic cells to produce IL-12 during the interaction with Th cells.Q54102042
Vaccination of glioma patients with fusions of dendritic and glioma cells and recombinant human interleukin 12.Q55471753
Expression of TGF-beta isoforms, TGF-beta receptors, and SMAD molecules at different stages of human glioma.Q55475527
TGF-beta suppresses IFN-gamma induction of class II MHC gene expression by inhibiting class II transactivator messenger RNA expression.Q55478696
TGF regulates the CD4+CD25+ T-cell pool and the expression of Foxp3 in vivoQ58131190
Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicabilityQ71615065
P433issue2
P921main subjecttoll-like receptorQ408004
dendritic cellQ506253
P304page(s)151-161
P577publication date2006-11-15
P1433published inJournal of Neuro-OncologyQ15752119
P1476titleToll-like receptor triggered dendritic cell maturation and IL-12 secretion are necessary to overcome T-cell inhibition by glioma-associated TGF-beta2.
P478volume82

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