The renin angiotensin system and the metabolic syndrome.

scientific article published in January 2010

The renin angiotensin system and the metabolic syndrome. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2174/1876526201003010001
P932PMC publication ID2995894
P698PubMed publication ID21132096
P5875ResearchGate publication ID244932604

P2093author name stringFeng Li
Nobuyuki Takahashi
Chih-Hong Wang
P2860cites workA novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9Q24290169
A unique exonic splice enhancer mutation in a family with X-linked mental retardation and epilepsy points to a novel role of the renin receptorQ24297376
Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to reninQ24298747
Differences in the properties and enzymatic specificities of the two active sites of angiotensin I-converting enzyme (kininase II). Studies with bradykinin and other natural peptidesQ24309254
Angiotensin-converting enzyme 2 is an essential regulator of heart functionQ28205840
Anti-apoptotic action of angiotensin fragments to neuronal cells from angiotensinogen knock-out miceQ28507336
Metabolic effects of low dose angiotensin converting enzyme inhibitor in dietary obesity in the ratQ28583121
Angiotensin converting enzyme and genetic hypertension: cloning of rat cDNAs and characterization of the enzymeQ28583658
Renin-dependent cardiovascular functions and renin-independent blood-brain barrier functions revealed by renin-deficient miceQ28586639
Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotesQ28592947
Angiotensinogen-deficient mice with hypotensionQ28594906
The metabolic syndrome--a new worldwide definitionQ29615125
Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific StatementQ29619465
A genetically clamped renin transgene for the induction of hypertensionQ30453336
The human B1 bradykinin receptor exhibits high ligand-independent, constitutive activity. Roles of residues in the fourth intracellular and third transmembrane domainsQ31778105
Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II.Q33593068
ACE insertion/deletion genotype affects bradykinin metabolismQ77227510
AT1 receptor A/C1166 polymorphism contributes to cardiac hypertrophy in subjects with hypertrophic cardiomyopathyQ77580246
Cross-talk between angiotensin II receptors and the tyrosine kinases and phosphatasesQ77804605
Insulin sensitivity, clearance and release in kininogen-deficient ratsQ77856198
Insulin sensitivity in patients with essential hypertension: no influence of the ACE inhibitor enalaprilQ78138825
The ACE insertion/deletion polymorphism is not associated with the metabolic syndrome (WHO Definition) in Brazilian type 2 diabetic patientsQ78579871
Haplotype analysis of the human renin gene and essential hypertensionQ78945499
Association of angiotensin converting enzyme gene I/D polymorphism with type 2 diabetes mellitusQ79254331
Prorenin and the (pro)renin receptor--an updateQ79678982
Deficiency of angiotensin type 2 receptor rescues obesity but not hypertension induced by overexpression of angiotensinogen in adipose tissueQ79696160
Aliskiren, a novel oral renin inhibitor, provides dose-dependent efficacy and placebo-like tolerability in Japanese patients with hypertensionQ80013636
Contribution of nonproteolytically activated prorenin in glomeruli to hypertensive renal damageQ80050975
Pharmacogenetic interactions between angiotensin-converting enzyme inhibitor therapy and the angiotensin-converting enzyme deletion polymorphism in patients with congestive heart failureQ80998610
Angiotensin II type 1 receptor gene polymorphism predicts development of hypertension and metabolic syndromeQ82678869
Beneficial effects of candesartan, an angiotensin II type 1 receptor blocker, on beta-cell function and morphology in db/db miceQ83226595
Metabolic syndrome: from epidemiology to systems biologyQ33691139
The angiotensin II type 2 receptor: an enigma with multiple variationsQ33858658
Genetically increased angiotensin I-converting enzyme level and renal complications in the diabetic mouseQ33949362
The ACE I/D polymorphism and human physical performance.Q34089011
Human B1 and B2 bradykinin receptors and their agonists target caveolae-related lipid rafts to different degrees in HEK293 cellsQ34160753
An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levelsQ34262228
Genetic control of blood pressure and the angiotensinogen locusQ34498129
Physiology of local renin-angiotensin systems.Q34543927
Mast cell tryptases and chymases in inflammation and host defenseQ34627778
Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice.Q34830604
Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; InternatQ35006662
The bradykinin B1 receptor and the central regulation of blood pressure in spontaneously hypertensive ratsQ35028743
Kinin B2 receptor is not involved in enalapril-induced apoptosis and regression of hypertrophy in spontaneously hypertensive rat aorta: possible role of B1 receptorQ35046131
ACE gene polymorphism and progression of diabetic nephropathy in Korean type 2 diabetic patients: effect of ACE gene DD on the progression of diabetic nephropathyQ35117583
Minireview: Computer Simulations of Blood Pressure Regulation by the Renin-Angiotensin SystemQ35127237
Brain renin-angiotensin system. Lessons from functional genomicsQ35601029
Human genetics, animal models and computer simulations for studying hypertensionQ35704389
Insights into angiotensin II receptor function through AT2 receptor knockout miceQ35850538
Loss of angiotensin-converting enzyme-2 (Ace2) accelerates diabetic kidney injuryQ35916066
Angiotensin receptors: a new role in cancer?Q36215159
Increased energy expenditure, dietary fat wasting, and resistance to diet-induced obesity in mice lacking reninQ36326017
The kinin system mediates hyperalgesia through the inducible bradykinin B1 receptor subtype: evidence in various experimental animal models of type 1 and type 2 diabetic neuropathyQ36404461
Renin inhibition reduces hypercholesterolemia-induced atherosclerosis in miceQ36458652
Renin/prorenin receptorsQ36467820
Mice lacking angiotensin-converting enzyme have increased energy expenditure, with reduced fat mass and improved glucose clearanceQ36638764
Review: Peroxisome proliferator-activated receptor gamma and adipose tissue--understanding obesity-related changes in regulation of lipid and glucose metabolismQ36674722
The (pro)renin receptor: pathophysiological roles in cardiovascular and renal pathologyQ36733551
The role of angiotensin AT1 receptor-associated protein in renin-angiotensin system regulation and functionQ36794938
Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgeneQ36853955
Improvement of insulin sensitivity by antagonism of the renin-angiotensin systemQ36854401
Aliskiren: a review of its use in the management of hypertensionQ36903748
Genetically altered animal models for Mas and angiotensin-(1-7).Q37044345
The kallikrein-kinin system in health and in diseases of the kidneyQ37070150
Prorenin and renin-induced extracellular signal-regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptideQ46796595
Role of kinin B1 and B2 receptors in a rat model of neuropathic painQ46817593
Deletion of angiotensin-converting enzyme 2 accelerates pressure overload-induced cardiac dysfunction by increasing local angiotensin II.Q46966464
Angiotensinogen-deficient mice exhibit impairment of diet-induced weight gain with alteration in adipose tissue development and increased locomotor activityQ47198714
ACE gene titration in mice uncovers a new mechanism for ACE on the control of body weightQ47401971
Bradykinin B2 receptor gene C-58T polymorphism and insulin resistance. A study on obese patients.Q47682665
A novel sequence polymorphism in the promoter region of the human B2-bradykinin receptor geneQ48064536
Prevention of adipose tissue depletion during food deprivation in angiotensin type 2 receptor-deficient miceQ48436429
Brain-specific restoration of angiotensin II corrects renal defects seen in angiotensinogen-deficient miceQ48459993
Involvement of the renin-angiotensin system in captopril-induced sodium appetite in the ratQ48632077
Targeting deletion of angiotensin type 1B receptor gene in the mouseQ48786167
Increased chymase activity in internal thoracic artery of patients with hypercholesterolemia.Q50514590
Renin-1 Is Essential for Normal Renal Juxtaglomerular Cell Granulation and Macula Densa MorphologyQ50947288
Angiotensin-converting enzyme gene polymorphism is associated with carotid arterial wall thickness in non-insulin-dependent diabetic patients.Q51014653
Association between angiotensin-1 converting enzyme gene polymorphism and the metabolic syndrome in a Mexican population.Q51468432
Study of the association between Alzheimer's disease and angiotensin-converting enzyme gene polymorphism using DNA from lymphocytes.Q52014922
Angiotensin II receptor blocker provides pancreatic beta-cell protection independent of blood pressure lowering in diabetic db/db mice.Q52576428
Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility.Q52909701
Nonproteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertension.Q53629064
Vasoactive potential of the b(1) bradykinin receptor in normotension and hypertension.Q54080020
Lifelong genetic minipumps.Q54690266
Cellular mechanism of vasoconstriction induced by angiotensin II: it remains to be determined.Q55037922
Detection of putative functional angiotensinogen (AGT) gene variants controlling plasma AGT levels by combined segregation-linkage analysisQ56893651
Highly Regulated Cell Type-restricted Expression of Human Renin in Mice Containing 140- or 160-Kilobase Pair P1 Phage Artificial Chromosome TransgenesQ56959216
Impairment of In Vitro and In Vivo Heart Function in Angiotensin-(1-7) Receptor Mas Knockout MiceQ56963485
Angiotensin converting enzyme insertion allele in relation to high altitude adaptationQ57111274
The associations of ACE polymorphisms with physical, physiological and skill parameters in adolescentsQ57243049
Quantitated transcript haplotypes (QTH) ofAGTR1, reduced abundance of mRNA haplotypes containing 1166C (rs5186:A>C), and relevance to metabolic syndrome traitsQ57273802
Insights derived from ACE knockout miceQ57630554
The Role of Angiotensin-Converting Enzyme in Blood Pressure Control, Renal Function, and Male FertilityQ57630584
Prorenin Induces Intracellular Signaling in Cardiomyocytes Independently of Angiotensin IIQ58223924
Association of (Pro)renin Receptor Gene Polymorphism With Blood Pressure in Japanese Men: The Ohasama StudyQ58363532
Male–female differences in fertility and blood pressure in ACE-deficient miceQ59055822
Insertion/deletion polymorphism in the angiotensin-l-converting enzyme gene is associated with coronary heart disease in IDDM patients with diabetic nephropathyQ61948435
Role of the Angiotensin Type 2 Receptor Gene in Congenital Anomalies of the Kidney and Urinary Tract, CAKUT, of Mice and MenQ63951732
Effect of chronic ACE inhibition on glucose tolerance and insulin sensitivity in hypertensive type 2 diabetic patientsQ67553260
Renin and angiotensin II receptor gene expression in kidneys of renal hypertensive ratsQ71819533
Targeted inactivation of the Ren-2 gene in miceQ71853661
Angiotensin-converting enzyme gene polymorphism has no influence on the circulating renin-angiotensin-aldosterone system or blood pressure in normotensive subjectsQ72347776
Angiotensin-converting enzyme gene mutations, blood pressures, and cardiovascular homeostasisQ73086476
Chymase is activated in the hamster heart following ventricular fibrosis during the chronic stage of hypertensionQ73309662
Late-onset obesity in mice transgenic for the human renin geneQ73368124
Angiotensin II type 1 receptor A1166C gene polymorphism is associated with an increased response to angiotensin II in human arteriesQ73556747
Angiotensin-converting enzyme gene polymorphism in non-insulin dependent diabetes mellitus and its relationship with diabetic nephropathyQ73604842
Synergistic effect of angiotensin II type 1 receptor genotype and poor glycaemic control on risk of nephropathy in IDDMQ73922985
The DD genotype of the ACE gene polymorphism is associated with diabetic nephropathy in the type-1 diabeticsQ74105791
Angiotensinogen gene null-mutant mice lack homeostatic regulation of glomerular filtration and tubular reabsorptionQ74326549
Renal angiotensin II receptor regulation and renin-angiotensin system inhibition in one-kidney, one clip hypertensive ratsQ74586359
The DD genotype of the ACE gene polymorphism is associated with progression of diabetic nephropathy to end stage renal failure in IDDMQ74661798
Angiotensin-converting enzyme 2 gene targeting studies in mice: mixed messagesQ37122931
eNOS, metabolic syndrome and cardiovascular disease.Q37317509
Prescription drug benefits and use of guideline recommended medications by elderly Medicare beneficiaries with diabetes mellitusQ37342702
(Pro)renin receptors: are they biologically relevant?Q37349060
A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitroQ37365783
Structure, expression, and regulation of the murine renin genesQ37377686
Aliskiren: an oral direct renin inhibitor for the treatment of hypertensionQ37377943
Diabetic nephropathy is markedly enhanced in mice lacking the bradykinin B2 receptorQ37513098
Kinin B1 receptor deficiency leads to leptin hypersensitivity and resistance to obesity.Q38292812
Molecular activation of PPARgamma by angiotensin II type 1-receptor antagonistsQ38312460
A single-nucleotide polymorphism in human angiotensinogen gene is associated with essential hypertension and affects glucocorticoid induced promoter activityQ38332479
Angiotensin II increases lipogenesis in 3T3-L1 and human adipose cellsQ38347486
The Brain Renin-Angiotensin SystemQ40141478
Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle" region for nonproteolytic activation of proreninQ40176844
Renin receptor expression in human adipose tissueQ40188300
Association between the angiotensin-converting enzyme-insertion/deletion polymorphism and diabetic nephropathy: a methodologic appraisal and systematic review.Q40844226
Angiotensin II--receptor subtypes characterization and pathophysiological implications.Q40993834
Differential expression of angiotensin receptor 1A and 1B in mouseQ41449603
Interplay of angiotensin II and angiotensin(1-7) in the regulation of matrix metalloproteinases of human cardiocytes.Q42525036
PPARgamma-activating angiotensin type-1 receptor blockers induce adiponectinQ42813848
Chymase inhibition provides pancreatic islet protection in hamsters with streptozotocin-induced diabetesQ43299150
Ren1d and Ren2 cooperate to preserve homeostasis: evidence from mice expressing GFP in place of Ren1dQ43632146
Renin polymorphisms and haplotypes are associated with blood pressure levels and hypertension risk in postmenopausal womenQ43653386
Bradykinin B2 receptor gene polymorphism is associated with altered urinary albumin/creatinine values in diabetic patients.Q44003398
ACE gene insertion/deletion polymorphism associated with 1998 World Health Organization definition of metabolic syndrome in Chinese type 2 diabetic patientsQ44007377
Chymase inhibition suppresses high-cholesterol diet-induced lipid accumulation in the hamster aortaQ44100854
Transgenic study of the function of chymase in heart remodelingQ44164798
Genetic variation in the renin-angiotensin system and abdominal adiposity in men: the Olivetti Prospective Heart StudyQ44269775
Direct biochemical evidence for eNOS stimulation by bradykinin in the human forearm vasculature.Q44329453
Chymase is upregulated in diabetic nephropathy: implications for an alternative pathway of angiotensin II-mediated diabetic renal and vascular diseaseQ44486184
Clustering of cardiovascular risk factors mimicking the human metabolic syndrome X in eNOS null mice.Q44568069
Modulation of allergic and immune complex-induced lung inflammation by bradykinin receptor antagonistsQ44800109
Angiotensin II type-1 receptor blocker valsartan enhances insulin sensitivity in skeletal muscles of diabetic miceQ44810052
The relation between obesity, abdominal fat deposit and the angiotensin-converting enzyme gene I/D polymorphism and its association with coronary heart disease.Q45134470
Ren1c homozygous null mice are hypotensive and polyuric, but heterozygotes are indistinguishable from wild-typeQ45162612
Targeting kinin B(1) receptor for therapeutic neovascularizationQ45882818
Prevalence of metabolic syndrome among adults 20 years of age and over, by sex, age, race and ethnicity, and body mass index: United States, 2003-2006.Q45919131
Angiotensin converting enzyme inhibition lowers body weight and improves glucose tolerance in C57BL/6J mice maintained on a high fat diet.Q45998990
ACE insertion/deletion polymorphism and its relationships to the components of metabolic syndrome in elderly Slovaks.Q46000711
Energy metabolism in human renin-gene transgenic rats: does renin contribute to obesity?Q46145636
Loss of angiotensin-converting enzyme 2 leads to impaired glucose homeostasis in mice.Q46290617
Renin inhibitor aliskiren improves impaired nitric oxide bioavailability and protects against atherosclerotic changesQ46470676
Attenuation of diet-induced weight gain and adiposity through increased energy expenditure in mice lacking angiotensin II type 1a receptorQ46477287
Angiotensin-(1-7) has a dual role on growth-promoting signalling pathways in rat heart in vivo by stimulating STAT3 and STAT5a/b phosphorylation and inhibiting angiotensin II-stimulated ERK1/2 and Rho kinase activityQ46617665
Angiotensin-converting enzyme inhibition after experimental myocardial infarct: role of the kinin B1 and B2 receptorsQ46696407
Half-life, hemodynamic, renal, and hormonal effects of prorenin in cynomolgus monkeysQ46728725
Critical role of bradykinin-eNOS and oxidative stress-LOX-1 pathway in cardiovascular remodeling under chronic angiotensin-converting enzyme inhibitionQ46743364
The influence of obesity and consequent insulin resistance on coronary risk factors in medically treated patients with coronary diseaseQ46758647
P921main subjectmetabolic syndromeQ657193
P304page(s)1-13
P577publication date2010-01-01
P1433published inThe open hypertension journalQ27723337
P1476titleThe renin angiotensin system and the metabolic syndrome.
P478volume3

Reverse relations

cites work (P2860)
Q34558074Angiotensin AT(2) receptor contributes towards gender bias in weight gain
Q91896482Antimetabolic Syndrome Effect of Phytosome Containing the Combined Extracts of Mulberry and Ginger in an Animal Model of Metabolic Syndrome
Q36521938Comparison of the relationships of alcoholic and nonalcoholic fatty liver with hypertension, diabetes mellitus, and dyslipidemia
Q51764431Correlation between the 24-h urinary angiotensinogen or aldosterone level and muscle mass: Japan shimanami health promoting program study.
Q42354239Effects of Azilsartan, Aliskiren or their Combination on High Fat Diet-induced Non-alcoholic Liver Disease Model in Rats
Q36228066Enhancement of Adipocyte Browning by Angiotensin II Type 1 Receptor Blockade
Q37434424Expression and clinical significance of angiotensin II type 1 receptor in human hepatocellular carcinoma
Q36208883High Na intake increases renal angiotensin II levels and reduces expression of the ACE2-AT(2)R-MasR axis in obese Zucker rats
Q41373148Hypoxia-induced proliferation in mesenchymal stem cells and angiotensin II-mediated PI3K/AKT pathway
Q35878038Pharmacologic effects of 2-methoxyestradiol on angiotensin type 1 receptor down-regulation in rat liver epithelial and aortic smooth muscle cells
Q35234255The role of mAKAPβ in the process of cardiomyocyte hypertrophy induced by angiotensin II

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