A randomized phase 2B trial of vancomycin versus daptomycin for the treatment of methicillin-resistant Staphylococcus aureus bacteremia due to isolates with high vancomycin minimum inhibitory concentrations - results of a prematurely terminated stud

scientific article published in June 2018

A randomized phase 2B trial of vancomycin versus daptomycin for the treatment of methicillin-resistant Staphylococcus aureus bacteremia due to isolates with high vancomycin minimum inhibitory concentrations - results of a prematurely terminated stud is …
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P6179Dimensions Publication ID1104354739
P356DOI10.1186/S13063-018-2702-8
P932PMC publication ID5984763
P698PubMed publication ID29859132

P50authorShirin KalimuddinQ97642409
David C. LyeQ42216661
P2093author name stringThuan Tong Tan
Jenny G H Low
Rachel Phillips
Sophia Archuleta
Siew Pei Ong
Yvonne F Z Chan
P2860cites workMethicillin-resistant Staphylococcus aureus therapy: past, present, and futureQ27011165
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Vancomycin-associated nephrotoxicity: grave concern or death by character assassination?Q33617737
Vancomycin versus daptomycin for the treatment of methicillin-resistant Staphylococcus aureus bacteremia due to isolates with high vancomycin minimum inhibitory concentrations: study protocol for a phase IIB randomized controlled trialQ33844670
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Daptomycin versus vancomycin for bloodstream infections due to methicillin-resistant Staphylococcus aureus with a high vancomycin minimum inhibitory concentration: a case-control studyQ82644438
Clinical characteristics of vancomycin minimum inhibitory concentration of 2 μg/ml methicillin-resistant Staphylococcus aureus strains isolated from patients with bacteremiaQ84563829
Influence of early daptomycin therapy on treatment outcome of meticillin-resistant Staphylococcus aureus bacteraemia with high vancomycin minimum inhibitory concentrationsQ85891650
Early use of daptomycin versus vancomycin for methicillin-resistant Staphylococcus aureus bacteremia with vancomycin minimum inhibitory concentration >1 mg/L: a matched cohort studyQ86222628
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Daptomycin versus standard therapy for bacteremia and endocarditis caused by Staphylococcus aureusQ34558111
Relationship of MIC and bactericidal activity to efficacy of vancomycin for treatment of methicillin-resistant Staphylococcus aureus bacteremiaQ34783668
Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia: a meta-analysisQ35030135
Pharmacokinetics and tolerability of daptomycin at doses up to 12 milligrams per kilogram of body weight once daily in healthy volunteersQ35091557
Daptomycin: another novel agent for treating infections due to drug-resistant gram-positive pathogensQ35701450
An association between bacterial genotype combined with a high-vancomycin minimum inhibitory concentration and risk of endocarditis in methicillin-resistant Staphylococcus aureus bloodstream infectionQ35745676
Vancomycin in vitro bactericidal activity and its relationship to efficacy in clearance of methicillin-resistant Staphylococcus aureus bacteremiaQ35879117
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Daptomycin Improves Outcomes Regardless of Vancomycin MIC in a Propensity-Matched Analysis of Methicillin-Resistant Staphylococcus aureus Bloodstream InfectionsQ37287739
Evaluation of vancomycin and daptomycin potency trends (MIC creep) against methicillin-resistant Staphylococcus aureus isolates collected in nine U.S. medical centers from 2002 to 2006.Q37392917
Safety of high-dose intravenous daptomycin treatment: three-year cumulative experience in a clinical programQ37509110
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Therapeutic monitoring of vancomycin in adults summary of consensus recommendations from the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases PharmacistsQ37623755
Adaptive clinical trials in oncologyQ37953783
The clinical significance of vancomycin minimum inhibitory concentration in Staphylococcus aureus infections: a systematic review and meta-analysis.Q37981103
Efficiencies of platform clinical trials: A vision of the futureQ38904226
Vancomycin MIC creep in methicillin-resistant Staphylococcus aureus (MRSA) isolates from 2006 to 2010 in a hospital in ChinaQ41084998
Predictors of persistent methicillin-resistant Staphylococcus aureus bacteraemia in patients treated with vancomycinQ43143854
Infectious diseases consultation and the management of Staphylococcus aureus bacteremiaQ44044205
The platform trial: an efficient strategy for evaluating multiple treatments.Q45982371
Red man syndrome: incidence, etiology, and prophylaxis.Q46032651
Are there differences in hospital cost between patients with nosocomial methicillin-resistant Staphylococcus aureus bloodstream infection and those with methicillin-susceptible S. aureus bloodstream infection?Q46062559
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P921main subjectStaphylococcus aureusQ188121
vancomycinQ424027
P304page(s)305
P577publication date2018-06-01
P1433published inTrialsQ7840023
P1476titleA randomized phase 2B trial of vancomycin versus daptomycin for the treatment of methicillin-resistant Staphylococcus aureus bacteremia due to isolates with high vancomycin minimum inhibitory concentrations - results of a prematurely terminated study
P478volume19