Abstract is: Geraniin is a dehydroellagitannin found in geraniums. It is found for instance in Geranium thunbergii, which is one of the most popular folk medicines and also an official antidiarrheic drug in Japan. It can also be found in the rind of Nephelium lappaceum (rambutan). It mediates apoptosis by cleavage of focal adhesion kinase through up-regulation of Fas ligand expression in human melanoma cells. Geraniin has also been shown to possess immunomodularity properties, as it inhibits tumor necrosis factor-alpha, and NF-κB in ovarian cancer cells. Geraniin was studied for its anticancer activity and shown to target apoptosis via inactivation of PI3K/Akt/mTOR signaling pathway involving NF-κB when treated against HT-29 human colorectal adenocarcinoma cells. It is formed with one hexahydroxydiphenic acid unit, one modified hexahydroxydiphenic acid unit (dehydrohexahydroxydiphenic acid or DHHDP) and one gallic acid unit linked to a glucose molecule. It is forming an equilibrium mixture of six-membered hemi-ketal and five-membered hemi-ketal forms. Chebulagic acid is formed from geraniin through a glutathione-mediated conversion.
P703 | found in taxon | Lotus corniculatus | Q29907 |
Euphorbia hirta | Q36177 | ||
Erodium cicutarium | Q157726 | ||
Parthenocissus tricuspidata | Q157979 | ||
Erodium moschatum | Q159800 | ||
Acer tataricum | Q162728 | ||
Geranium sibiricum | Q163088 | ||
Acalypha hispida | Q163528 | ||
Euphorbia helioscopia | Q148889 | ||
Geum japonicum | Q164367 | ||
Euphorbia maculata | Q177322 | ||
Spondias mombin | Q794969 | ||
Euphorbia nutans | Q798313 | ||
Phyllanthus emblica | Q310050 | ||
Acer maximowiczianum | Q1038831 | ||
Phyllanthus urinaria | Q1131974 | ||
Nymphaea tetragona | Q244009 | ||
Terminalia catappa | Q271179 | ||
Cercidiphyllum japonicum | Q526549 | ||
Triadica sebifera | Q702175 | ||
Euphorbia tirucalli | Q883685 | ||
Euphorbia prostrata | Q1023705 | ||
Acalypha wilkesiana | Q1377693 | ||
Vernicia fordii | Q1422363 | ||
Carpinus laxiflora | Q4147190 | ||
Geranium thunbergii | Q5236828 | ||
Elaeocarpus sylvestris | Q5367459 | ||
Acalypha australis | Q6676255 | ||
Tamarix chinensis | Q6825364 | ||
Bischofia javanica | Q8248272 | ||
Coriaria japonica | Q8340253 | ||
Acer nikoense | Q9578385 | ||
Quercus gambelii | Q2266358 | ||
Geum aleppicum | Q2585830 | ||
Phyllanthus sellowianus | Q10349256 | ||
Phyllanthus tenellus | Q10882137 | ||
Excoecaria kawakamii | Q10893561 | ||
Phyfnnvik eyyfn | Q2719836 | ||
Geum macrophyllum | Q2917893 | ||
Excoecaria agallocha | Q5419710 | ||
Geranium viscosissimum | Q5549882 | ||
Euphorbia thymifolia | Q10904925 | ||
Macaranga sinensis | Q10915064 | ||
Macaranga tanarius | Q3020630 | ||
Acalypha indica | Q3339634 | ||
Phyllanthus flexuosus | Q15247375 | ||
Acalypha poiretii | Q15286864 | ||
Erodium glaucophyllum | Q15327345 | ||
Nymphaea pygmaea | Q21396688 | ||
Antidesma montanum var. montanum | Q25119230 | ||
Euphorbia scordiifolia | Q15389558 | ||
Heterocentron subtriplinervium | Q15389920 | ||
Acer ginnala | Q15634290 | ||
Euphorbia jolkinii | Q10936724 | ||
Euphorbia makinoi | Q10958092 | ||
Mallotus philippinensis | Q104253278 | ||
Phyllanthus amarus | Q11034878 | ||
Mallotus repandus | Q11076094 | ||
Phyllanthus virgatus | Q11178012 | ||
Euphorbia supina | Q12605986 | ||
Euphorbia humifusa | Q12847854 | ||
Euphorbia watanabei | Q14937068 | ||
Geranium rectum | Q15227519 | ||
Mallotus japonicus | Q15236078 | ||
Phyllanthus myrtifolius | Q15246934 | ||
P2067 | mass | 952.081796 | |
P3364 | stereoisomer of | JQQBXPCJFAKSPG-DBBVXFTCSA-N | Q105133602 |
JQQBXPCJFAKSPG-OTYJEXDISA-N | Q105133603 |
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