Dopamine Transporter/α-Synuclein Complexes Are Altered in the Post Mortem Caudate Putamen of Parkinson's Disease: An In Situ Proximity Ligation Assay Study.

scientific article published on 30 May 2018

Dopamine Transporter/α-Synuclein Complexes Are Altered in the Post Mortem Caudate Putamen of Parkinson's Disease: An In Situ Proximity Ligation Assay Study. is …
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scholarly articleQ13442814

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P356DOI10.3390/IJMS19061611
P932PMC publication ID6032099
P698PubMed publication ID29848975

P50authorGaia FaustiniQ59568327
Arianna BellucciQ59568334
Francesca LonghenaQ88924449
P2093author name stringCristina Missale
Marina Pizzi
P2860cites workThe synaptic pathology of alpha-synuclein aggregation in dementia with Lewy bodies, Parkinson's disease and Parkinson's disease dementiaQ22252705
Redistribution of DAT/α-synuclein complexes visualized by "in situ" proximity ligation assay in transgenic mice modelling early Parkinson's diseaseQ24299645
Modulation of dopamine transporter function by alpha-synuclein is altered by impairment of cell adhesion and by induction of oxidative stressQ24320119
Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson's disease brainQ24321216
Mechanisms of dopamine transporter regulation in normal and disease statesQ24598750
α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodiesQ24653247
The Synaptic Function of α-SynucleinQ27694711
Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine systemQ28594502
Direct observation of individual endogenous protein complexes in situ by proximity ligationQ29616032
Phosphorylated α-synuclein in Parkinson's diseaseQ30510167
Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis.Q33941736
SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson's diseaseQ33944220
alpha-Synuclein is phosphorylated in synucleinopathy lesionsQ34111460
Attenuation of dopamine transporter activity by alpha-synucleinQ34187960
Regulation of the Dopamine and Vesicular Monoamine Transporters: Pharmacological Targets and Implications for DiseaseQ34673305
Neuropathologic features of Parkinson's, Huntington's, and Alzheimer's diseasesQ35346723
α-Synuclein stimulates a dopamine transporter-dependent chloride current and modulates the activity of the transporter.Q35626155
Impaired neurotransmission caused by overexpression of α-synuclein in nigral dopamine neuronsQ35807528
Functional alterations of the dopaminergic and glutamatergic systems in spontaneous α-synuclein overexpressing rats.Q36172332
Dopamine Transporter Activity Is Modulated by α-Synuclein.Q36444116
Structural and functional properties of prefibrillar α-synuclein oligomersQ36796130
Serine 129 phosphorylation of membrane-associated α-synuclein modulates dopamine transporter function in a G protein-coupled receptor kinase-dependent mannerQ36887384
Disease duration and the integrity of the nigrostriatal system in Parkinson's diseaseQ37043102
Regulation of dopamine transporter function by protein-protein interactions: new discoveries and methodological challenges.Q37677837
Axonal damage and loss of connectivity in nigrostriatal and mesolimbic dopamine pathways in early Parkinson's disease.Q37737032
Synuclein modulation of monoamine transportersQ37852164
Novel Strategies for Drug Discovery Based on Intrinsically Disordered Proteins (IDPs)Q37891686
The "in situ" proximity ligation assay to probe protein-protein interactions in intact tissuesQ38306271
Review: Parkinson's disease: from synaptic loss to connectome dysfunction.Q38650395
Intracellular Dynamics of Synucleins: "Here, There and Everywhere".Q38651392
The clathrin-dependent localization of dopamine transporter to surface membranes is affected by α-synucleinQ39094270
Disruption of the interaction of alpha-synuclein with microtubules enhances cell surface recruitment of the dopamine transporterQ40363580
α-synuclein and synapsin III cooperatively regulate synaptic function in dopamine neuronsQ42476891
Decreased reuptake of dopamine in the dorsal striatum in the absence of α-synuclein.Q42483202
The End Is the Beginning: Parkinson's Disease in the Light of Brain Imaging.Q42700405
Alpha-synuclein aggregation and cell death triggered by energy deprivation and dopamine overload are counteracted by D2/D3 receptor activationQ44632120
Nigral burden of alpha-synuclein correlates with striatal dopamine deficitQ46467299
Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body diseaseQ46593989
Targeting of Disordered Proteins by Small Molecules in Neurodegenerative DiseasesQ47720283
Synapsin III is a key component of α-synuclein fibrils in Lewy bodies of PD brainsQ47866245
Dopamine transporter imaging does not predict the number of nigral neurons in Parkinson diseaseQ48268875
Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders.Q48586171
Immunochemical analysis of dopamine transporter protein in Parkinson's diseaseQ48742316
Effects of exogenous alpha-synuclein on stimulated dopamine overflow in dorsal striatumQ49051594
Nigrostriatal dopamine transporter availability in early Parkinson's diseaseQ50047313
Alpha-synuclein aggregates activate calcium pump SERCA leading to calcium dysregulation.Q51732455
In Situ Proximity Ligation Assay Reveals Co-Localization of Alpha-Synuclein and SNARE Proteins in Murine Primary NeuronsQ52330497
Extreme disorder in an ultrahigh-affinity protein complex.Q52375447
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectputamenQ550934
Parkinson's diseaseQ11085
SynucleinQ24767155
P304page(s)1611
P577publication date2018-05-30
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titleDopamine Transporter/α-Synuclein Complexes Are Altered in the Post Mortem Caudate Putamen of Parkinson's Disease: An In Situ Proximity Ligation Assay Study
P478volume19

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cites work (P2860)
Q89251186Is Braak staging valid for all types of Parkinson's disease?
Q97519880KTN1 Variants Underlying Putamen Gray Matter Volumes and Parkinson's Disease
Q60922145Living in Promiscuity: The Multiple Partners of Alpha-Synuclein at the Synapse in Physiology and Pathology
Q92150656Revealing Adenosine A2A-Dopamine D2 Receptor Heteromers in Parkinson's Disease Post-Mortem Brain through a New AlphaScreen-Based Assay

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