Synthetic diversification of natural products: semi-synthesis and evaluation of triazole jadomycins

Synthetic diversification of natural products: semi-synthesis and evaluation of triazole jadomycins is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1039/C2SC00663D

P2093author name stringDavid L. Jakeman
Ray T. Syvitski
Susan E. Douglas
Andrew W. Robertson
Sherri A. McFarland
Kerry B. Goralski
Stephanie N. Dupuis
Susan M. A. Monro
Thomas Veinot
P2860cites workJadomycins derived from the assimilation and incorporation of norvaline and norleucineQ39448636
Jadomycin B, an Aurora-B kinase inhibitor discovered through virtual screeningQ39947742
Stereochemical integrity of oxazolone ring-containing jadomycins.Q40119502
Cytotoxic activities of new jadomycin derivatives.Q40374826
Total synthesis of jadomycin A and a carbasugar analogue of jadomycin B.Q42530492
Gene expression enabling synthetic diversification of natural products: chemogenetic generation of pacidamycin analogsQ42936568
Biomimetic synthesis and structural refinement of the macrocyclic dimer aminoglycoside 66-40C--the remarkably selective self-condensation of a putative aldehyde intermediate in the submerged culture medium producing sisomicinQ43134300
The dynamic structure of jadomycin B and the amino acid incorporation step of its biosynthesisQ44834541
Culture conditions improving the production of jadomycin B.Q51239832
Copper-mediated nuclease activity of jadomycin B.Q53248527
Substrate flexibility of a 2,6-dideoxyglycosyltransferaseQ56536124
Novel jadomycins: incorporation of non-natural and natural amino acidsQ56536126
Recent advances in betalain researchQ30320604
Natural-product sugar biosynthesis and enzymatic glycodiversificationQ30492476
Mutational biosynthesis--a tool for the generation of structural diversity in the biosynthesis of antibioticsQ33211659
Total synthesis approaches to natural product derivatives based on the combination of chemical synthesis and metabolic engineeringQ33301352
Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azidesQ33958790
Substrate specificity of strictosidine synthaseQ34494915
Halogenation strategies in natural product biosynthesisQ34753169
Copper-catalyzed azide-alkyne cycloaddition (CuAAC) and beyond: new reactivity of copper(I) acetylidesQ34775159
Natural products to drugs: natural product-derived compounds in clinical trialsQ34780898
The impact of enzyme engineering upon natural product glycodiversificationQ34803952
Cu-catalyzed azide-alkyne cycloadditionQ34807878
Mutasynthesis, chemobiosynthesis, and back to semi-synthesis: combining synthetic chemistry and biosynthetic engineering for diversifying natural productsQ37077332
Antimicrobial activities of jadomycin B and structurally related analoguesQ37115717
Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesisQ37721369
P433issue5
P921main subjectnatural productQ901227
P304page(s)1640
P577publication date2012-01-01
P1433published inChemical ScienceQ2962267
P1476titleSynthetic diversification of natural products: semi-synthesis and evaluation of triazole jadomycins
P478volume3

Reverse relations

cites work (P2860)
Q48131343Biosynthetic 4,6-dehydratase gene deletion: isolation of a glucosylated jadomycin natural product provides insight into the substrate specificity of glycosyltransferase JadS.
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Q39417729Promiscuity of a modular polyketide synthase towards natural and non-natural extender units.
Q42087716Streptomyces venezuelae ISP5230 Maintains Excretion of Jadomycin upon Disruption of the MFS Transporter JadL Located within the Natural Product Biosynthetic Gene Cluster
Q53787497Total synthesis of jadomycins B, S, T, and ILEVS1080.
Q85937813Use of a biosynthetic intermediate to explore the chemical diversity of pseudo-natural fungal polyketides