Abnormal CTLA-4 function in T cells from patients with systemic lupus erythematosus

scholarly article by Elizabeth C Jury et al published February 2010 in European Journal of Immunology

Abnormal CTLA-4 function in T cells from patients with systemic lupus erythematosus is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/EJI.200939781
P698PubMed publication ID19950182

P50authorElizabeth C JuryQ91503421
David A. IsenbergQ42326409
Michael R EhrensteinQ60017325
Claudia MauriQ60317802
Fabian Flores-BorjaQ63921647
P2093author name stringMark Lazarus
Hardeep S Kalsi
P2860cites workIncreased T-lymphocyte apoptosis in lupus correlates with disease activity and may be responsible for reduced T-cell frequency: a cross-sectional and longitudinal studyQ84173080
Exocytosis of CTLA-4 is dependent on phospholipase D and ADP ribosylation factor-1 and stimulated during activation of regulatory T cellsQ24299640
Interaction of the cytoplasmic tail of CTLA-4 (CD152) with a clathrin-associated protein is negatively regulated by tyrosine phosphorylationQ24313151
Decreased effector memory CD45RA+ CD62L- CD8+ T cells and increased central memory CD45RA- CD62L+ CD8+ T cells in peripheral blood of rheumatoid arthritis patientsQ24804104
CTLA-4 can function as a negative regulator of T cell activationQ28235866
Reversal of the TCR stop signal by CTLA-4Q28259985
Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4Q28284177
A native soluble form of CTLA-4Q28565263
Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4Q29619280
CTLA-4 control over Foxp3+ regulatory T cell functionQ29619413
Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.Q34509694
Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosusQ34574768
Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell developmentQ34597933
CTLA4 mediates antigen-specific apoptosis of human T cellsQ34735857
Abnormal T cell signal transduction in systemic lupus erythematosusQ34736534
Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotypeQ36059631
T- and B-cell abnormalities in systemic lupus erythematosusQ36161314
Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation.Q36189566
Aggregation of lipid rafts accompanies signaling via the T cell antigen receptorQ36326042
Surface cytotoxic T lymphocyte-associated antigen 4 partitions within lipid rafts and relocates to the immunological synapse under conditions of inhibition of T cell activationQ36370285
Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4.Q36370461
Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synoviaQ36403785
A molecular perspective of CTLA-4 functionQ36427322
Altered dynamics of Kv1.3 channel compartmentalization in the immunological synapse in systemic lupus erythematosusQ36755899
Global T cell dysregulation in non-autoimmune-prone mice promotes rapid development of BAFF-independent, systemic lupus erythematosus-like autoimmunityQ36983608
Agrin signalling contributes to cell activation and is overexpressed in T lymphocytes from lupus patientsQ37001191
Regulatory T cells in systemic lupus erythematosus: past, present and futureQ37129619
CTLA4 expression is an indicator and regulator of steady-state CD4+ FoxP3+ T cell homeostasisQ37196273
Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways.Q37256978
Altered lipid raft-associated signaling and ganglioside expression in T lymphocytes from patients with systemic lupus erythematosusQ37370498
Altered pattern of TCR/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus. Deficient expression of the T cell receptor zeta chainQ37380253
Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine productionQ40165347
Cytotoxic T lymphocyte antigen 4 and CD28 modulate cell surface raft expression in their regulation of T cell functionQ42108511
CTLA-4 suppresses proximal TCR signaling in resting human CD4(+) T cells by inhibiting ZAP-70 Tyr(319) phosphorylation: a potential role for tyrosine phosphatasesQ43968794
Alterations in lipid raft composition and dynamics contribute to abnormal T cell responses in systemic lupus erythematosusQ44929014
Enhanced propensity of T lymphocytes in patients with systemic lupus erythematosus to apoptosis in the presence of tumour necrosis factor alphaQ46182117
Decreased T cell response to anti-CD2 in systemic lupus erythematosus and reversal by anti-CD28: evidence for impaired T cell-accessory cell interactionQ46793771
Differential expression of CTLA-4 among T cell subsetsQ47594359
Evidence for CTLA4 as a susceptibility gene for systemic lupus erythematosusQ47618195
T effectors outfox T regulators in autoimmunityQ48213336
Atorvastatin restores Lck expression and lipid raft-associated signaling in T cells from patients with systemic lupus erythematosus.Q52574763
Clinical manifestations and analyses of the cytotoxic T-lymphocyte associated-4 gene in two Japanese families with systemic lupus erythematosus.Q53442368
T cell receptor-interacting molecule acts as a chaperone to modulate surface expression of the CTLA-4 coreceptor.Q53591138
Ctla-4 controls regulatory T cell peripheral homeostasis and is required for suppression of pancreatic islet autoimmunityQ56900258
Evidence for unique association signals in SLE at the CD28-CTLA4-ICOS locus in a family-based studyQ56901838
Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivoQ56901901
Aberrant production of soluble costimulatory molecules CTLA-4, CD28, CD80 and CD86 in patients with systemic lupus erythematosusQ56902724
CTLA-4 polymorphisms and systemic lupus erythematosus (SLE): a meta-analysisQ56902905
Increased expression of soluble cytotoxic T-lymphocyte-associated antigen-4 molecule in patients with systemic lupus erythematosusQ56903910
CTLA-4 gene polymorphisms in systemic lupus erythematosus: a highly significant association with a determinant in the promoter regionQ56904218
A polymorphism in the human cytotoxic T-lymphocyte antigen 4 ( CTLA4) gene (exon 1 +49) alters T-cell activationQ56904549
CTLA-4 gene polymorphism in promoter and exon-1 regions in Chinese patients with systemic lupus erythematosusQ56905656
Expression of CTLA-4 molecule in peripheral blood T lymphocytes from patients with systemic lupus erythematosusQ56907452
Preferential elimination of CD28+ T cells in systemic lupus erythematosus (SLE) and the relation with activation-induced apoptosisQ56908725
FOXP3 Identifies Regulatory CD25brightCD4+ T Cells in Rheumatic JointsQ57349726
Increased T-lymphocyte apoptosis/necrosis and IL-10 producing cells in patients and their spouses in Icelandic systemic lupus erythematosus multicase familiesQ57350796
Global Natural Regulatory T Cell Depletion in Active Systemic Lupus ErythematosusQ61050853
Abnormal differentiation of memory T cells in systemic lupus erythematosusQ79794971
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectsystemic lupus erythematosusQ1485
P304page(s)569-78
P577publication date2010-02-01
P1433published inEuropean Journal of ImmunologyQ5412727
P1476titleAbnormal CTLA-4 function in T cells from patients with systemic lupus erythematosus
P478volume40

Reverse relations

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