Fully human agonist antibodies to TrkB using autocrine cell-based selection from a combinatorial antibody library

article published in the Proceedings of the National Academy of Sciences of the United States of America

Fully human agonist antibodies to TrkB using autocrine cell-based selection from a combinatorial antibody library is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1073/PNAS.1806660115
P932PMC publication ID6065019
P698PubMed publication ID29987039

P50authorYves-Alain BardeQ30106726
Nicholas AllenQ58887759
Pedro Chacón-FernándezQ89046192
Nicholas C WuQ39722696
Xinsheng NanQ40991312
P2093author name stringMeng Li
Peter S DiStefano
Richard A Lerner
Jia Xie
Geramie Grande
Chih-Wei Lin
Alexey V Stepanov
Kate E Binley
Ronald M Lindsay
Spyros Merkouris
P2860cites workA de novo mutation affecting human TrkB associated with severe obesity and developmental delayQ24307838
Activin A directs striatal projection neuron differentiation of human pluripotent stem cellsQ24324143
Identification of a novel mutation in the NTF4 gene that causes primary open-angle glaucoma in a Chinese populationQ24628693
Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesisQ24651301
Heterozygous NTF4 mutations impairing neurotrophin-4 signaling in patients with primary open-angle glaucomaQ24657994
Experimental observations on the development of polarity by hippocampal neurons in cultureQ24679532
Neurotrophin signal transduction in the nervous systemQ27876223
Recent advances in the development of anti-HER2 antibodies and antibody-drug conjugatesQ28083123
Synaptotagmin-2 is essential for survival and contributes to Ca2+ triggering of neurotransmitter release in central and neuromuscular synapsesQ28280944
Phosphatidylinositol 3-Akt-kinase-dependent phosphorylation of p21(Waf1/Cip1) as a novel mechanism of neuroprotection by glucocorticoidsQ28569805
The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal functionQ29615582
Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signalingQ29615601
Mutation screen of the brain derived neurotrophic factor gene (BDNF): Identification of several genetic variants and association studies in patients with obesity, eating disorders, and attention-deficit/hyperactivity disorderQ57285564
Binding characteristics of brain-derived neurotrophic factor to its receptors on neurons from the chick embryoQ69839044
Effects of brain-derived neurotrophic factor on motor dysfunction in wobbler mouse motor neuron diseaseQ72157868
A controlled trial of recombinant methionyl human BDNF in ALS: The BDNF Study Group (Phase III)Q77398255
Upscaling of hiPS Cell-Derived Neurons for High-Throughput ScreeningQ89351015
Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin miceQ30486668
Short-term striatal gene expression responses to brain-derived neurotrophic factor are dependent on MEK and ERK activationQ33434423
A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone.Q33664194
The brain-derived neurotrophic factor enhances synthesis of Arc in synaptoneurosomesQ34013346
Autocrine signaling based selection of combinatorial antibodies that transdifferentiate human stem cellsQ34036456
Transport of human recombinant brain-derived neurotrophic factor (BDNF) through the rat blood-brain barrier in vivo using vector-mediated peptide drug deliveryQ34060172
The neuroplasticity-associated arc gene is a direct transcriptional target of early growth response (Egr) transcription factorsQ34150847
Pharmacological characterization of six trkB antibodies reveals a novel class of functional agents for the study of the BDNF receptorQ34588700
Activation of TrkB with TAM-163 results in opposite effects on body weight in rodents and non-human primatesQ34734974
Selecting agonists from single cells infected with combinatorial antibody librariesQ34740000
A monoclonal antibody TrkB receptor agonist as a potential therapeutic for Huntington's diseaseQ35087700
Optimizing the use of anti-tumor necrosis factor in the management of patients with Crohn's diseaseQ35561386
Autocrine selection of a GLP-1R G-protein biased agonist with potent antidiabetic effectsQ35856484
Bevacizumab (Avastin), a humanized anti-VEGF monoclonal antibody for cancer therapyQ36165553
Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome.Q36212795
FDA drug approval summary: panitumumab (Vectibix).Q36830592
Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotectionQ36959335
Up-regulation of brain-derived neurotrophic factor by application of fibroblast growth factor-2 to the cut optic nerve is important for long-term survival of retinal ganglion cells.Q36984309
A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndromeQ37008339
Brain-derived neurotrophic factor prevents dendritic retraction of adult mouse retinal ganglion cells.Q37183432
A small molecule TrkB ligand reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington's diseaseQ37345118
Neurotrophin signalling: novel insights into mechanisms and pathophysiologyQ37629100
More Insight into BDNF against Neurodegeneration: Anti-Apoptosis, Anti-Oxidation, and Suppression of Autophagy.Q37729120
Potential therapeutic uses of BDNF in neurological and psychiatric disordersQ37848053
Pharmaceutical Characterization of Tropomyosin Receptor Kinase B-Agonistic Antibodies on Human Induced Pluripotent Stem (hiPS) Cell-Derived NeuronsQ38738325
Clinical tests of neurotrophic factors for human neurodegenerative diseases, part 2: Where do we stand and where must we go next?Q38804084
Forced cell cycle exit and modulation of GABAA, CREB, and GSK3β signaling promote functional maturation of induced pluripotent stem cell-derived neurons.Q38807798
Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neuronsQ38810200
Activin induces cortical interneuron identity and differentiation in embryonic stem cell-derived telencephalic neural precursorsQ39347922
An agonistic TrkB mAb causes sustained TrkB activation, delays RGC death, and protects the retinal structure in optic nerve axotomy and in glaucomaQ39720313
Novel agonist monoclonal antibodies activate TrkB receptors and demonstrate potent neurotrophic activities.Q40232259
Trophic support of motoneurons: physiological, pathophysiological, and therapeutic implications.Q40801545
Gadd45b is a novel mediator of neuronal apoptosis in ischemic strokeQ41978642
Co-infusion with a TrkB-Fc receptor body carrier enhances BDNF distribution in the adult rat brain.Q42060253
Neurons associated with aggrecan-based perineuronal nets are protected against tau pathology in subcortical regions in Alzheimer's disease.Q42471938
Brain-derived neurotrophic factor (BDNF) prevents the degeneration of medial septal cholinergic neurons following fimbria transectionQ42497039
Brain-derived neurotrophic factor (BDNF)-induced synthesis of early growth response factor 3 (Egr3) controls the levels of type A GABA receptor alpha 4 subunits in hippocampal neuronsQ42499572
Withdrawal of BDNF from hippocampal cultures leads to changes in genes involved in synaptic functionQ43148661
The non-peptidyl fungal metabolite L-783,281 activates TRK neurotrophin receptorsQ43735224
TrkB agonists ameliorate obesity and associated metabolic conditions in miceQ46212129
Critical role for DP5/Harakiri, a Bcl-2 homology domain 3-only Bcl-2 family member, in axotomy-induced neuronal cell death.Q47763741
Multiplex quantitative assays indicate a need for reevaluating reported small-molecule TrkB agonists.Q47791149
A phase I/II trial of recombinant methionyl human brain derived neurotrophic factor administered by intrathecal infusion to patients with amyotrophic lateral sclerosisQ48686925
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivs 4.0 InternationalQ24082749
P6216copyright statuscopyrightedQ50423863
P433issue30
P407language of work or nameEnglishQ1860
P304page(s)E7023-E7032
P577publication date2018-07-09
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleFully human agonist antibodies to TrkB using autocrine cell-based selection from a combinatorial antibody library
P478volume115

Reverse relations

cites work (P2860)
Q94601574Brain-Derived Neurotrophic Factor and Its Potential Therapeutic Role in Stroke Comorbidities
Q90696093Function-based high-throughput screening for antibody antagonists and agonists against G protein-coupled receptors
Q90149640Renoprotective effects of a novel cMet agonistic antibody on kidney fibrosis