HIV-Specific, Ex Vivo Expanded T Cell Therapy: Feasibility, Safety, and Efficacy in ART-Suppressed HIV-Infected Individuals

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HIV-Specific, Ex Vivo Expanded T Cell Therapy: Feasibility, Safety, and Efficacy in ART-Suppressed HIV-Infected Individuals is …
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scholarly articleQ13442814

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P356DOI10.1016/J.YMTHE.2018.08.015
P932PMC publication ID6171327
P698PubMed publication ID30249388

P50authorShabnum PatelQ87592399
Joseph J EronQ87874621
Catherine M BollardQ91774704
Nancie M ArchinQ106613342
JoAnn D KurucQ106614334
David M. MargolisQ37380199
P2093author name stringNilu Goonetilleke
Cynthia L Gay
Patrick J Hanley
C Russell Cruz
Julia A Sung
Matthew L Clohosey
Tamara Tripic
Clio M Rooney
Lauren Roesch
P2860cites workCommon genetic variation and the control of HIV-1 in humansQ21092450
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Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapyQ34290545
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Natural killer cells migrate into and control simian immunodeficiency virus replication in lymph node follicles in African green monkeys.Q45326279
Depletion of CD8+ cells in sooty mangabey monkeys naturally infected with simian immunodeficiency virus reveals limited role for immune control of virus replication in a natural host speciesQ45403270
Safety of autologous, ex vivo-expanded human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte infusion in HIV-infected patients.Q45760355
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In vivo fate of HIV-1-infected T cells: quantitative analysis of the transition to stable latency.Q52050894
Design and analysis of serial limiting dilution assays with small sample sizes.Q52224088
Simian Immunodeficiency Virus (SIV)-Specific Chimeric Antigen Receptor-T Cells Engineered to Target B Cell Follicles and Suppress SIV Replication.Q52608538
Interleukin-15-Stimulated Natural Killer Cells Clear HIV-1-Infected Cells following Latency ReversalQ57425155
Re-emergence of HIV after stopping therapyQ59060012
Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progressionQ71803154
Broadly-specific cytotoxic T cells targeting multiple HIV antigens are expanded from HIV+ patients: implications for immunotherapyQ35653249
CMV-specific T cells generated from naïve T cells recognize atypical epitopes and may be protective in vivoQ35776868
Definition of the viral targets of protective HIV-1-specific T cell responsesQ35800157
Expanded cytotoxic T-cell lymphocytes target the latent HIV reservoirQ35812943
Innate Immune Activity Correlates with CD4 T Cell-Associated HIV-1 DNA Decline during Latency-Reversing Treatment with PanobinostatQ36086345
Precise Quantitation of the Latent HIV-1 Reservoir: Implications for Eradication StrategiesQ36148964
Dual-Affinity Re-Targeting proteins direct T cell-mediated cytolysis of latently HIV-infected cellsQ36266486
IL-7 induces expression and activation of integrin α4β7 promoting naive T-cell homing to the intestinal mucosaQ36286857
Expanding cytotoxic T lymphocytes from umbilical cord blood that target cytomegalovirus, Epstein-Barr virus, and adenovirusQ36305254
Migratory properties of naive, effector, and memory CD8(+) T cellsQ36369485
Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivationQ36409885
Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapyQ36499290
Acute HIV-1 infection in the Southeastern United States: a cohort studyQ36509575
HLA-B*57 versus HLA-B*81 in HIV-1 infection: slow and steady wins the race?Q36759787
HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppressionQ36781531
New real-time reverse transcriptase-initiated PCR assay with single-copy sensitivity for human immunodeficiency virus type 1 RNA in plasmaQ36891848
Dilution assay statisticsQ37073320
HLA-A*7401-mediated control of HIV viremia is independent of its linkage disequilibrium with HLA-B*5703Q37081581
The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infectionQ37273195
Functionally active virus-specific T cells that target CMV, adenovirus, and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopesQ37334642
Valproic acid without intensified antiviral therapy has limited impact on persistent HIV infection of resting CD4+ T cellsQ37393518
T-cell therapy in the treatment of post-transplant lymphoproliferative diseaseQ38026758
HIV and HLA class I: an evolving relationshipQ38045636
Cytotoxic T lymphocytes for leukemia and lymphomaQ38361829
Cell-Mediated Immunity to Target the Persistent Human Immunodeficiency Virus ReservoirQ38777005
Induction of multifunctional human immunodeficiency virus type 1 (HIV-1)-specific T cells capable of proliferation in healthy subjects by using a prime-boost regimen of DNA- and modified vaccinia virus Ankara-vectored vaccines expressing HIV-1 Gag cQ39028785
IL-15 induces the expression of chemokines and their receptors in T lymphocytes.Q39349797
HDAC inhibition induces HIV-1 protein and enables immune-based clearance following latency reversalQ40080802
Vorinostat Renders the Replication-Competent Latent Reservoir of Human Immunodeficiency Virus (HIV) Vulnerable to Clearance by CD8 T CellsQ40084640
Interval dosing with the HDAC inhibitor vorinostat effectively reverses HIV latencyQ40120304
CXCR5-Dependent Entry of CD8 T Cells into Rhesus Macaque B-Cell Follicles Achieved through T-Cell EngineeringQ40290381
CD8(+) Lymphocytes Are Required for Maintaining Viral Suppression in SIV-Infected Macaques Treated with Short-Term Antiretroviral Therapy.Q40532397
Control of the HIV-1 DNA Reservoir Is Associated In Vivo and In Vitro with NKp46/NKp30 (CD335 CD337) Inducibility and Interferon Gamma Production by Transcriptionally Unique NK CellsQ41928841
In vivo expansion of LMP 1- and 2-specific T-cells in a patient who received donor-derived EBV-specific T-cells after allogeneic stem cell transplantationQ43572619
Improving T-cell therapy for epstein-barr virus lymphoproliferative disordersQ43714922
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectmolecular biologyQ7202
pharmacologyQ128406
drug discoveryQ1418791
molecular medicineQ3523816
P304page(s)2496-2506
P577publication date2018-09-21
P1433published inMolecular TherapyQ15762400
P1476titleHIV-Specific, Ex Vivo Expanded T Cell Therapy: Feasibility, Safety, and Efficacy in ART-Suppressed HIV-Infected Individuals
P478volume26

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cites work (P2860)
Q90630528Chronic inflammation mediates brain injury in HIV infection: relevance for cure strategies
Q90707628Curing HIV: Seeking to Target and Clear Persistent Infection
Q64100454Harnessing CD8 T Cells Under HIV Antiretroviral Therapy
Q92134571Measuring the Success of HIV-1 Cure Strategies
Q95272150Nanoparticle-Based Immunoengineered Approaches for Combating HIV
Q60046873Therapeutic Targeting of HIV Reservoirs: How to Give T Cells a New Direction
Q98291353Virus-Specific T Cell Therapies for HIV: Lessons Learned From Hematopoietic Stem Cell Transplantation

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