A Phase 1/2 Study of evofosfamide, A Hypoxia-Activated Prodrug with or without Bortezomib in Subjects with Relapsed/Refractory Multiple Myeloma

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A Phase 1/2 Study of evofosfamide, A Hypoxia-Activated Prodrug with or without Bortezomib in Subjects with Relapsed/Refractory Multiple Myeloma is …
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scholarly articleQ13442814

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P356DOI10.1158/1078-0432.CCR-18-1325
P932PMC publication ID6335171
P698PubMed publication ID30279233

P50authorIrene GhobrialQ88032966
Kalvis HornburgQ88246173
P2093author name stringMichael Martin
Kenneth C Anderson
Paul G Richardson
Jacalyn Rosenblatt
Chia-Jen Liu
Jacob P Laubach
Stacey Chuma
Kenneth H Shain
Andrew J Yee
Philippe Armand
Robert L Schlossman
Bradley Rivotto
Noopur S Raje
Craig Reynolds
Stew Kroll
Damian R Handisides
Alexandra Savell
Laura Stampleman
Henry J Dumke
Ira Zackon
Jacquelyn Hedlund
Patrick Henrick
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Elotuzumab Therapy for Relapsed or Refractory Multiple MyelomaQ41700620
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Phase 1 Study of the Safety, Tolerability, and Pharmacokinetics of TH-302, a Hypoxia-Activated Prodrug, in Patients with Advanced Solid MalignanciesQ42745781
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The bone-marrow niche in MDS and MGUS: implications for AML and MM.Q50114615
Safety Outcomes for Autologous Stem Cell Transplant in Multiple MyelomaQ50163135
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Low bone marrow oxygen tension and hypoxia-inducible factor-1α overexpression characterize patients with multiple myeloma: role on the transcriptional and proangiogenic profiles of CD138+ cellsQ60197167
P433issue2
P407language of work or nameEnglishQ1860
P921main subjecthypoxiaQ105688
P304page(s)478-486
P577publication date2018-10-02
P1433published inClinical Cancer ResearchQ332253
P1476titleA Phase I/II Study of Evofosfamide, A Hypoxia-activated Prodrug with or without Bortezomib in Subjects with Relapsed/Refractory Multiple Myeloma
P478volume25

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cites work (P2860)
Q96343724Why Great Mitotic Inhibitors Make Poor Cancer Drugs
Q64100298mRNA-to-protein translation in hypoxia

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