Is topical or intravenous tranexamic acid preferred in total hip arthroplasty? A randomized, controlled, noninferiority clinical trial

scientific article published in PLoS ONE

Is topical or intravenous tranexamic acid preferred in total hip arthroplasty? A randomized, controlled, noninferiority clinical trial is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PONE.0204551
P932PMC publication ID6168126
P698PubMed publication ID30278067

P50authorJian-Min FengQ91969527
P2093author name stringYi Wang
Chuan He
Zhi-Hong Liu
Hong-Yi Wang
Kai-di Zhou
P2860cites workThe use of antifibrinolytic agents in total hip arthroplasty: a meta-analysisQ80206688
Topical vs Intravenous Tranexamic Acid in Primary Total Hip Arthroplasty: A Double-Blind, Randomized Controlled TrialQ86971827
Cost benefit analysis of topical tranexamic acid in primary total hip and knee arthroplastyQ87445238
Comparison of topical and intravenous tranexamic acid on blood loss and transfusion rates in total hip arthroplastyQ87654595
Comparison of intravenous versus topical tranexamic acid in total knee arthroplasty: a prospective randomized studyQ87758762
Comparison between intravenous and intra-articular regimens of tranexamic acid in reducing blood loss during total knee arthroplastyQ87846916
Tranexamic acid, given at the end of the operation, does not reduce postoperative blood loss in hip arthroplastyQ93937185
Tranexamic acid: a review of its use in surgery and other indicationsQ33684291
Allogenic blood transfusion following total hip arthroplasty: results from the nationwide inpatient sample, 2000 to 2009.Q34159025
Clinical pharmacology of aminocaproic and tranexamic acidsQ34302597
Systemic hemostatic medications for reducing surgical blood lossQ34325848
Tranexamic acid reduces blood loss after cementless total hip arthroplasty-prospective randomized study in 40 casesQ36327509
Do antifibrinolytics reduce allogeneic blood transfusion in orthopedic surgery?Q36634947
Topical tranexamic acid reduces blood loss and transfusion rates in total hip and total knee arthroplastyQ37253804
Use of antifibrinolytic therapy to reduce transfusion in patients undergoing orthopedic surgery: a systematic review of randomized trialsQ37325204
A systematic review and meta-analysis of the topical administration of tranexamic acid in total hip and knee replacement.Q38236234
The effectiveness and safety of tranexamic acid in total hip or knee arthroplasty: a meta-analysis of 2720 casesQ38512062
The response of the fibrinolytic system in trauma.Q39823641
Seroprevalence of hepatitis viruses and risk factors in blood donors of Veracruz, Mexico.Q41222440
Prediction of blood volume in normal human adults.Q41564951
Topical intra-articular compared with intravenous tranexamic acid to reduce blood loss in primary total knee replacement: a double-blind, randomized, controlled, noninferiority clinical trialQ41730481
A systematic review and meta-analysis comparing combined intravenous and topical tranexamic acid with intravenous administration alone in THAQ42706668
Topical application of tranexamic acid reduces postoperative blood loss in total knee arthroplasty: a randomized, controlled trial.Q42837549
Use of Intravenous Tranexamic Acid to Reduce Allogeneic Blood Transfusion in Total Hip and Knee Arthroplasty: A Meta-analysisQ44644645
The effect of tranexamic acid on transfusion rate in primary total hip arthroplastyQ44986260
Influence of tranexamic acid on postoperative autologous blood retransfusion in primary total hip and knee arthroplasty: a randomized controlled trialQ45737273
Topical (intra-articular) tranexamic acid reduces blood loss and transfusion rates following total hip replacement: a randomized controlled trial (TRANX-H).Q46468416
Tranexamic Acid Administration in Primary Total Hip Arthroplasty: A Randomized Controlled Trial of Intravenous Combined with Topical Versus Single-Dose Intravenous Administration.Q50797250
Topical administration of tranexamic acid in primary total hip and total knee arthroplasty.Q53308290
Comparing efficacy of three methods of tranexamic acid administration in reducing hemoglobin drop following total knee arthroplasty.Q53576241
Estimating allowable blood loss: corrected for dilutionQ71676684
Initial plasmin-degradation of fibrin as the basis of a positive feed-back mechanism in fibrinolysisQ72815075
The effect of tranexamic acid on local and plasma fibrinolysis during total knee arthroplastyQ73127997
Use of tranexamic acid for an effective blood conservation strategy after total knee arthroplastyQ73446457
How much blood is really lost in total knee arthroplasty?. Correct blood loss management should take hidden loss into accountQ74115135
An analysis of blood management in patients having a total hip or knee arthroplastyQ78108769
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue10
P407language of work or nameEnglishQ1860
P921main subjecttranexamic acidQ418666
P304page(s)e0204551
P577publication date2018-10-02
P1433published inPLOS OneQ564954
P1476titleIs topical or intravenous tranexamic acid preferred in total hip arthroplasty? A randomized, controlled, noninferiority clinical trial
P478volume13

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