Cytocidal effects of arenobufagin and hellebrigenin, two active bufadienolide compounds, against human glioblastoma cell line U-87

Cytocidal effects of arenobufagin and hellebrigenin, two active bufadienolide compounds, against human glioblastoma cell line U-87 is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3892/IJO.2018.4567
P932PMC publication ID6203163
P698PubMed publication ID30272276

P2093author name stringBo Yuan
Hideki Hayashi
Norio Takagi
Baolin Bian
Hai-Yu Zhao
Nan Si
Lingyu Han
Ryota Shimada
P2860cites workBufalin induces G2/M phase arrest and triggers autophagy via the TNF, JNK, BECN-1 and ATG8 pathway in human hepatoma cellsQ39151531
Arenobufagin, a natural bufadienolide from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway.Q39197590
ERK inhibition enhances TSA-induced gastric cancer cell apoptosis via NF-κB-dependent and Notch-independent mechanismQ39316942
Proteasome inhibitor MG132 induces selective apoptosis in glioblastoma cells through inhibition of PI3K/Akt and NFkappaB pathways, mitochondrial dysfunction, and activation of p38-JNK1/2 signaling.Q39389835
Progressive activation of CyclinB1-Cdk1 coordinates entry to mitosisQ39711792
The efficacy and safety of bufadienolides-loaded nanostructured lipid carriersQ39715782
Activation of p38 MAPK and/or JNK contributes to increased levels of VEGF secretion in human malignant glioma cellsQ40233547
Silencing of Survivin Expression Leads to Reduced Proliferation and Cell Cycle Arrest in Cancer CellsQ40376534
Survivin enhances radiation resistance in primary human glioblastoma cells via caspase-independent mechanismsQ40522890
Contribution of aquaporin 9 and multidrug resistance-associated protein 2 to differential sensitivity to arsenite between primary cultured chorion and amnion cells prepared from human fetal membranesQ41847628
Hellebrigenin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells through inhibition of Akt.Q42705111
Clinical observation of cinobufacini injection used to treat moderate and advanced primary liver cancerQ44560150
Glial lipoproteins stimulate axon growth of central nervous system neurons in compartmented culturesQ44717175
Imbalance between ROS production and elimination results in apoptosis induction in primary smooth chorion trophoblast cells prepared from human fetal membrane tissuesQ46782810
Meta-analysis of radiation therapy with and without adjuvant chemotherapy for malignant gliomas in adultsQ48303492
Involvement of histone H3 phosphorylation via the activation of p38 MAPK pathway and intracellular redox status in cytotoxicity of HL-60 cells induced by Vitex agnus-castus fruit extract.Q53708329
Nuclear survivin expression predicts poorer prognosis in glioblastomaQ79708813
Distribution of Th17 cells and FoxP3(+) regulatory T cells in tumor-infiltrating lymphocytes, tumor-draining lymph nodes and peripheral blood lymphocytes in patients with gastric cancerQ84411479
Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinasesQ24632768
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Survivin and Tumorigenesis: Molecular Mechanisms and Therapeutic StrategiesQ26766250
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastomaQ27860910
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Effect of As2O3 on cell cycle progression and cyclins D1 and B1 expression in two glioblastoma cell lines differing in p53 statusQ31077540
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p38 mitogen-activated protein kinase promotes cell survival in response to DNA damage but is not required for the G(2) DNA damage checkpoint in human cancer cellsQ34045669
Plasma pharmacokinetics and tissue distribution of bufotalin in mice following single-bolus injection and constant-rate infusion of bufotalin solutionQ34163249
Origin of the U87MG glioma cell line: Good news and bad newsQ34539119
High-grade malignant glioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-upQ34620657
p38α mediates cell survival in response to oxidative stress via induction of antioxidant genes: effect on the p70S6K pathwayQ35710005
Regulation of Cdc25C activity during the meiotic G2/M transition.Q35770132
Arenobufagin intercalates with DNA leading to G2 cell cycle arrest via ATM/ATR pathwayQ36544066
Molecularly targeted therapy for malignant gliomaQ36829847
Improved microfluorometric DNA determination in biological material using 33258 HoechstQ36895188
MK2 inhibitor reduces alkali burn-induced inflammation in rat corneaQ37027411
Drug discovery approaches targeting the PI3K/Akt pathway in cancerQ37270455
Inhibition of p38 MAPK sensitizes tumour cells to cisplatin-induced apoptosis mediated by reactive oxygen species and JNK.Q37342850
Blockade of vascular endothelial growth factor receptors by tivozanib has potential anti-tumour effects on human glioblastoma cellsQ37695245
T-regulatory cells: key players in tumor immune escape and angiogenesisQ38006901
Synergistic cytotoxic effects of arsenite and tetrandrine in human breast cancer cell line MCF-7.Q38698775
HDAC4 and HDAC6 sustain DNA double strand break repair and stem-like phenotype by promoting radioresistance in glioblastoma cellsQ38710507
β-Arrestin 1 has an essential role in neurokinin-1 receptor-mediated glioblastoma cell proliferation and G2/M phase transitionQ38710607
Effects of active bufadienolide compounds on human cancer cells and CD4+CD25+Foxp3+ regulatory T cells in mitogen-activated human peripheral blood mononuclear cellsQ38757283
Delphinidin induces cytotoxicity and potentiates cytocidal effect in combination with arsenite in an acute promyelocytic leukemia NB4 cell lineQ38877761
Involvement of histone H3 phosphorylation through p38 MAPK pathway activation in casticin-induced cytocidal effects against the human promyelocytic cell line HL-60.Q39092247
Contribution of membrane progesterone receptor α to the induction of progesterone-mediated apoptosis associated with mitochondrial membrane disruption and caspase cascade activation in Jurkat cell lines.Q39114994
Vandetanib combined with a p38 MAPK inhibitor synergistically reduces glioblastoma cell survivalQ39137585
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectglioblastomaQ282142
P304page(s)2488-2502
P577publication date2018-09-20
P1433published inInternational Journal of OncologyQ6051527
P1476titleCytocidal effects of arenobufagin and hellebrigenin, two active bufadienolide compounds, against human glioblastoma cell line U-87
P478volume53

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cites work (P2860)
Q94552407Arenobufagin Promoted Oxidative Stress-Associated Mitochondrial Pathway Apoptosis in A549 Non-Small-Cell Lung Cancer Cell Line
Q93188465Chemopreventive and anticancer activity of flavonoids and its possibility for clinical use by combining with conventional chemotherapeutic agents

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