β-Cell Failure or β-Cell Abuse?

β-Cell Failure or β-Cell Abuse? is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3389/FENDO.2018.00532
P932PMC publication ID6146038
P698PubMed publication ID30271382

P2093author name stringBarbara E Corkey
Karel Erion
P2860cites workFibrates are an essential part of modern anti-dyslipidemic arsenal: spotlight on atherogenic dyslipidemia and residual risk reductionQ21246041
Environmental chemicals and type 2 diabetes: an updated systematic review of the epidemiologic evidenceQ27027739
Mechanisms of fatty acid-induced inhibition of glucose uptakeQ28369732
Evaluation of the association between persistent organic pollutants (POPs) and diabetes in epidemiological studies: a national toxicology program workshop reviewQ28385151
Proinsulin conversion in GH3 cells after coexpression of human proinsulin with the endoproteases PC2 and/or PC3Q28609897
Increased basal level of Akt-dependent insulin signaling may be responsible for the development of insulin resistanceQ30434586
Trajectories of glycaemia, insulin sensitivity and insulin secretion in South Asian and white individuals before diagnosis of type 2 diabetes: a longitudinal analysis from the Whitehall II cohort study.Q33843643
Childhood size and life course weight characteristics in association with the risk of incident type 2 diabetesQ33873200
What Are We Putting in Our Food That Is Making Us Fat? Food Additives, Contaminants, and Other Putative Contributors to ObesityQ33914328
Endocrine disruptors in the etiology of type 2 diabetes mellitus.Q34176083
Bisphenol-A acts as a potent estrogen via non-classical estrogen triggered pathwaysQ34245582
Effects of bezafibrate on lipid and glucose metabolism in dyslipidemic patients with diabetes: the J-BENEFIT studyQ34262967
Gymnema sylvestre stimulates insulin release in vitro by increased membrane permeabilityQ34505731
Both fasting and glucose-stimulated proinsulin levels predict hyperglycemia and incident type 2 diabetes: a population-based study of 9,396 Finnish menQ35325334
Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitusQ35552583
Effects of fat on glucose uptake and utilization in patients with non-insulin-dependent diabetesQ35762624
Chronic Exposure to Excess Nutrients Left-shifts the Concentration Dependence of Glucose-stimulated Insulin Secretion in Pancreatic β-CellsQ35783124
Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjectsQ35809532
Inhibition of Monoacylglycerol Lipase Activity Decreases Glucose-Stimulated Insulin Secretion in INS-1 (832/13) Cells and Rat IsletsQ35920878
Mode of action of fibrates in the regulation of triglyceride and HDL-cholesterol metabolismQ36411159
Balanced pan-PPAR activator bezafibrate in combination with statin: comprehensive lipids control and diabetes prevention?Q36411656
Diabetes: have we got it all wrong? Insulin hypersecretion and food additives: cause of obesity and diabetes?Q36426723
Evaluation of the association between maternal smoking, childhood obesity, and metabolic disorders: a national toxicology program workshop reviewQ36602285
Gastric bypass surgery vs intensive lifestyle and medical intervention for type 2 diabetes: the CROSSROADS randomised controlled trialQ36784428
Adolescent BMI trajectory and risk of diabetes versus coronary diseaseQ37080874
Metabolic syndrome, hyperinsulinemia, and cancerQ37081280
Bimodal distribution of glucose is not universally useful for diagnosing diabetesQ37105153
Antidiabetic action of bezafibrate in a large observational databaseQ37139567
Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II study.Q37304741
Disproportionately Elevated Proinsulin Levels as an Early Indicator of β-Cell Dysfunction in Nondiabetic Offspring of Chinese Diabetic Patients.Q37322694
Insulin-dependent regulation of insulin receptor concentrations: a direct demonstration in cell culture.Q37428285
Hepatic insulin clearance is the primary determinant of insulin sensitivity in the normal dog.Q37672590
Hyperinsulinemic syndrome: the metabolic syndrome is broader than you thinkQ38223003
Hyperinsulinemia: a Cause of Obesity?Q39280021
Improvement in insulin secretion in diabetes after diazoxideQ39368203
Coxsackie B4 viruses with the potential to damage beta cells of the islets are present in clinical isolatesQ39502998
Proinsulin, insulin, and C-peptide concentrations in human portal and peripheral bloodQ40369831
A high fasting plasma insulin concentration predicts type 2 diabetes independent of insulin resistance: evidence for a pathogenic role of relative hyperinsulinemia.Q40734688
Central insulin administration reduces neuropeptide Y mRNA expression in the arcuate nucleus of food-deprived lean (Fa/Fa) but not obese (fa/fa) Zucker ratsQ41182816
Insulin and BMI as predictors of adult type 2 diabetes mellitusQ41656099
Overnight inhibition of insulin secretion restores pulsatility and proinsulin/insulin ratio in type 2 diabetes.Q41756772
Diabetes and its drivers: the largest epidemic in human history?Q42338492
NN414, a SUR1/Kir6.2-Selective Potassium Channel Opener, Reduces Blood Glucose and Improves Glucose Tolerance in the VDF Zucker RatQ42450731
Metformin restores insulin secretion altered by chronic exposure to free fatty acids or high glucose: a direct metformin effect on pancreatic beta-cellsQ42490936
The possible mechanisms by which phanoside stimulates insulin secretion from rat isletsQ42507924
Antiobesity effect of diazoxide in obese Zucker ratsQ42516151
Diazoxide down-regulates leptin and lipid metabolizing enzymes in adipose tissue of Zucker rats.Q42804860
Induction of beta-cell rest by a Kir6.2/SUR1-selective K(ATP)-channel opener preserves beta-cell insulin stores and insulin secretion in human islets cultured at high (11 mM) glucoseQ44757149
Attenuation of hyperinsulinemia by NN414, a SUR1/Kir6.2 selective K-adenosine triphosphate channel opener, improves glucose tolerance and lipid profile in obese Zucker ratsQ44815328
Openers of ATP-dependent K+-channels protect against a signal-transduction-linked and not freely reversible defect of insulin secretion in a rat islet transplantation model of Type 2 diabetesQ44847063
beta-Cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysisQ45105931
Serum proinsulin levels at fasting and after oral glucose load in patients with type 2 (non-insulin-dependent) diabetes mellitusQ46161786
The effects of NN414, a SUR1/Kir6.2 selective potassium channel opener, in healthy male subjectsQ46542206
Very slow turnover of beta-cells in aged adult miceQ46670100
Weight and Metabolic Outcomes 12 Years after Gastric BypassQ47186948
Increasing body mass index z-score is continuously associated with complications of overweight in children, even in the healthy weight rangeQ47313868
Intraventricular insulin and the level of maintained body weight in ratsQ47352883
Effect of chronic insulin administration on food intake and body weight in ratsQ47424600
Metformin regulates metabolic and nonmetabolic pathways in skeletal muscle and subcutaneous adipose tissues of older adultsQ48136074
A 2-year Trial of Intermittent Insulin Therapy versus Metformin for the Preservation of Beta-cell Function after Initial Short-term Intensive Insulin Induction in early Type 2 Diabetes.Q48151386
Prospective evaluation of insulin and incretin dynamics in obese adults with and without diabetes for 2 years after Roux-en-Y gastric bypass.Q50079410
Roux-en-Y gastric bypass corrects hyperinsulinemia implications for the remission of type 2 diabetes.Q50520401
Long-term effects of laparoscopic Roux-en-Y gastric bypass on diabetes mellitus, hypertension and dyslipidaemia in morbidly obese patients.Q51318977
Decreased number of insulin receptors in obesity: studies in the obese hyperglycemic mouse (author's transl)Q51671363
Childhood adiposity, adult adiposity, and cardiovascular risk factors.Q53141828
Effect of sustained physiologic hyperinsulinaemia and hyperglycaemia on insulin secretion and insulin sensitivity in man.Q54194095
Down regulation of insulin receptors in primary cultures of adult rat hepatocytes in monolayerQ67442152
Concomitant food intake and adipose tissue responses under chronic insulin infusion in ratsQ70255794
Kinetics of proinsulin conversion in human isletsQ70721752
Effects of a 48-h fat infusion on insulin secretion and glucose utilizationQ71736931
Beneficial effect of diazoxide in obese hyperinsulinemic adultsQ74645788
Acute lowering of plasma fatty acids lowers basal insulin secretion in diabetic and nondiabetic subjectsQ77349175
Long-term effect of bezafibrate on pancreatic beta-cell function and insulin resistance in patients with diabetesQ80257227
The effects of NN414, a SUR1/Kir6.2 selective potassium channel opener in subjects with type 2 diabetesQ80802150
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P304page(s)532
P577publication date2018-01-01
P1433published inFrontiers in EndocrinologyQ27723680
P1476titleβ-Cell Failure or β-Cell Abuse?
P478volume9

Reverse relations

cites work (P2860)
Q99602876Augmented mitochondrial energy metabolism is an early response to chronic glucose stress in human pancreatic beta cells
Q64255905Targeting the Zinc Transporter ZIP7 in the Treatment of Insulin Resistance and Type 2 Diabetes

Search more.