Emerging ways to treat breast cancer: will promises be met?

scientific article published on 27 September 2018

Emerging ways to treat breast cancer: will promises be met? is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S13402-018-0409-1
P698PubMed publication ID30259416

P50authorMona PourjafarQ88040056
P2093author name stringMassoud Saidijam
Fatemeh Karimi Dermani
Pouria Samadi
Sahar Saki
P2860cites workCirculating microRNAs in plasma as early detection markers for breast cancer.Q54294896
The current state of breast cancer classification.Q54481775
[Role of let-7 in maintaining characteristics of breast cancer stem cells].Q54492842
A phase II, randomized, blinded study of the farnesyltransferase inhibitor tipifarnib combined with letrozole in the treatment of advanced breast cancer after antiestrogen therapyQ57579980
Inside the professionalsQ59099495
Phase II study of cisplatin and 5-fluorouracil in previously treated metastatic breast cancer: an Eastern Cooperative Oncology Group study (PA 185)Q73272415
Vaccination of women with metastatic breast cancer, using a costimulatory gene (CD80)-modified, HLA-A2-matched, allogeneic, breast cancer cell line: clinical and immunological resultsQ73717915
Immunization of cancer patients with a HER-2/neu, HLA-A2 peptide, p369-377, results in short-lived peptide-specific immunityQ74079764
Correlation and quantitation of microRNA aberrant expression in tissues and sera from patients with breast tumorQ84963968
miR-892b Silencing Activates NF-κB and Promotes Aggressiveness in Breast CancerQ87043923
Targeting a Long Noncoding RNA in Breast CancerQ87616370
Zerumbone inhibits epithelial-mesenchymal transition and cancer stem cells properties by inhibiting the β-catenin pathway through miR-200cQ89254595
PD-1/PD-L1 immune checkpoint: Potential target for cancer therapyQ91327338
Serum microRNAs are promising novel biomarkersQ21144238
MicroRNAs and their target gene networks in breast cancerQ21195211
Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cellsQ21245767
A multidrug resistance transporter from human MCF-7 breast cancer cellsQ22008574
Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cellsQ24300024
MicroRNA-155 regulates cell survival, growth, and chemosensitivity by targeting FOXO3a in breast cancerQ24603354
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasisQ24607308
MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1Q24648241
Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer modelQ24655262
CRISPR/Cas9 therapeutics: a cure for cancer and other genetic diseasesQ26744172
MicroRNA therapeutics: Discovering novel targets and developing specific therapyQ26747644
Injecting Hope--A Review of Breast Cancer VaccinesQ26748882
Roles, Functions, and Mechanisms of Long Non-coding RNAs in CancerQ26765422
Targeting Oncogenic Mutant p53 for Cancer TherapyQ26770856
PI3K/Akt/mTOR inhibitors in breast cancerQ26771394
Breast cancer intrinsic subtype classification, clinical use and future trendsQ26773761
MEK and PI3K inhibition in solid tumors: rationale and evidence to dateQ26775573
Discovery and functional analysis of lncRNAs: Methodologies to investigate an uncharacterized transcriptomeQ26781885
Targeting Breast Cancer MetastasisQ26783925
PARP inhibitors in the management of breast cancer: current data and future prospectsQ26798352
Local and Systemic Therapies for Breast Cancer Patients: Reducing Short-term Symptoms with the Methods of Integrative MedicineQ26800265
Targeting the Bcl-2 family for cancer therapyQ26866936
CTLA-4 blockade in tumor models: an overview of preclinical and translational researchQ26992295
Innate and adaptive immune cells in the tumor microenvironmentQ27008342
Dendritic cell-based vaccination in cancer: therapeutic implications emerging from murine modelsQ27012618
Rationale for targeting the Ras/MAPK pathway in triple-negative breast cancerQ27022169
miRNA-based therapies: strategies and delivery platforms for oligonucleotide and non-oligonucleotide agentsQ27023295
Small molecule compounds targeting the p53 pathway: are we finally making progress?Q27027835
The multikinase inhibitor Sorafenib enhances glycolysis and synergizes with glycolysis blockade for cancer cell killing.Q35183284
Global cancer statistics, 2012Q27860501
RAS is regulated by the let-7 microRNA familyQ27860522
The functions of animal microRNAsQ27860621
MicroRNA gene expression deregulation in human breast cancerQ27860690
Silencing of microRNAs in vivo with 'antagomirs'Q27860891
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cellsQ27860960
The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1Q27861068
MicroRNAs: genomics, biogenesis, mechanism, and functionQ27861070
The role of lymphangiogenesis and angiogenesis in tumor metastasisQ28067309
Akt inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review)Q28080599
MicroRNAs in breast cancer: oncogene and tumor suppressors with clinical potentialQ28081081
miR-221/222 targets adiponectin receptor 1 to promote the epithelial-to-mesenchymal transition in breast cancerQ28115315
Tumour invasion and metastasis initiated by microRNA-10b in breast cancerQ28131829
miR-29a suppresses tristetraprolin, which is a regulator of epithelial polarity and metastasisQ28236600
let-7 microRNA functions as a potential growth suppressor in human colon cancer cellsQ28237683
Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cellsQ28256740
let-7 regulates self renewal and tumorigenicity of breast cancer cellsQ28261263
The heterochronic microRNA let-7 inhibits cell motility by regulating the genes in the actin cytoskeleton pathway in breast cancerQ28283868
Exosomes from drug-resistant breast cancer cells transmit chemoresistance by a horizontal transfer of microRNAsQ28537958
Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trialsQ29547513
MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancerQ29547523
MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancerQ29614237
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroupsQ29614700
CRISPR-Cas systems for editing, regulating and targeting genomesQ29615781
Cancer drug resistance: an evolving paradigmQ29616694
Endogenous human microRNAs that suppress breast cancer metastasisQ29617352
Breast cancer vaccines: a clinical reality or fairy tale?Q30351838
Breast tissue composition and susceptibility to breast cancerQ30474496
CD13 is a therapeutic target in human liver cancer stem cellsQ30496324
The SWI/SNF ATPases Are Required for Triple Negative Breast Cancer Cell ProliferationQ30659086
Retracted: miR-221 Promotes Tumorigenesis in Human Triple Negative Breast Cancer CellsQ31116416
Genome-scale microRNA and small interfering RNA screens identify small RNA modulators of TRAIL-induced apoptosis pathwayQ33305776
MiR-155 promotes proliferation of human breast cancer MCF-7 cells through targeting tumor protein 53-induced nuclear protein 1Q33586516
Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasisQ33591140
Status of adjuvant endocrine therapy for breast cancerQ33739138
Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonizationQ35204515
Transgenic microRNA inhibition with spatiotemporal specificity in intact organisms.Q35244937
Apoptosis in cancer: from pathogenesis to treatmentQ35397889
A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition.Q35503722
Trends in breast biopsy pathology diagnoses among women undergoing mammography in the United States: a report from the Breast Cancer Surveillance ConsortiumQ35567577
Targeted therapies for ER+/HER2- metastatic breast cancerQ35658860
Various types and management of breast cancer: an overviewQ35664703
Results of clinical trials with an allogenic melanoma tumor cell lysate vaccine: MelacineQ35682712
Pivotal role of vascular endothelial growth factor pathway in tumor angiogenesisQ35782469
LncRNA-ATB promotes trastuzumab resistance and invasion-metastasis cascade in breast cancerQ35793883
The Roles of MicroRNAs in Breast CancerQ35818407
Downregulation of long noncoding RNA MALAT1 induces epithelial-to-mesenchymal transition via the PI3K-AKT pathway in breast cancer.Q35853987
Neoadjuvant Bevacizumab plus Chemotherapy versus Chemotherapy Alone to Treat Non-Metastatic Breast Cancer: A Meta-Analysis of Randomised Controlled TrialsQ35881780
Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumorsQ35906418
Carboplatin in combination therapy for metastatic breast cancerQ35914912
The miR-106b-25 cluster targets Smad7, activates TGF-β signaling, and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer.Q35928749
Continuous 5-fluorouracil in the treatment of breast cancerQ36079497
Small-molecule inhibitors of microrna miR-21 functionQ36192700
Exosome removal as a therapeutic adjuvant in cancerQ36232064
Claudin-Low Breast Cancer; Clinical & Pathological CharacteristicsQ36237815
Polyclonal HER2-specific antibodies induced by vaccination mediate receptor internalization and degradation in tumor cells.Q36245418
The silent treatment: siRNAs as small molecule drugsQ36362370
TGF-β upregulates miR-181a expression to promote breast cancer metastasisQ36497263
Systemic treatment in breast cancer: a primer for radiologistsQ36510679
miR-29b sensitizes multiple myeloma cells to bortezomib-induced apoptosis through the activation of a feedback loop with the transcription factor Sp1Q36525161
The combinatorial activation of the PI3K and Ras/MAPK pathways is sufficient for aggressive tumor formation, while individual pathway activation supports cell persistenceQ36546319
The roles of binding site arrangement and combinatorial targeting in microRNA repression of gene expressionQ36643186
A Phase I Trial of BKM120 (Buparlisib) in Combination with Fulvestrant in Postmenopausal Women with Estrogen Receptor-Positive Metastatic Breast CancerQ36759372
Genetic heterogeneity of breast cancer metastasis may be related to miR-21 regulation of TIMP-3 in translationQ37045230
Modeling invasive lobular breast carcinoma by CRISPR/Cas9-mediated somatic genome editing of the mammary glandQ37051766
MicroRNA-328 negatively regulates the expression of breast cancer resistance protein (BCRP/ABCG2) in human cancer cellsQ37199087
In vivo delivery of miRNAs for cancer therapy: challenges and strategies.Q37228217
NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcomaQ37311506
MiR-222 and miR-29a contribute to the drug-resistance of breast cancer cells.Q39102148
MiR-487a resensitizes mitoxantrone (MX)-resistant breast cancer cells (MCF-7/MX) to MX by targeting breast cancer resistance protein (BCRP/ABCG2).Q39121337
Epigenetic modulation of the miR-200 family is associated with transition to a breast cancer stem-cell-like stateQ39176448
miR-200a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cellsQ39539625
Gap junction-mediated import of microRNA from bone marrow stromal cells can elicit cell cycle quiescence in breast cancer cellsQ39587807
Hereditary breast cancer: the era of new susceptibility genesQ39657506
A CD80-transfected human breast cancer cell variant induces HER-2/neu-specific T cells in HLA-A*02-matched situations in vitro as well as in vivoQ40515986
Induction of ErbB-2/neu-specific protective and therapeutic antitumor immunity using genetically modified dendritic cells: enhanced efficacy by cotransduction of gene encoding IL-12.Q40811138
Immunization with a peptide epitope (p369-377) from HER-2/neu leads to peptide-specific cytotoxic T lymphocytes that fail to recognize HER-2/neu+ tumors.Q40995818
High XIST and Low 53BP1 Expression Predict Poor Outcome after High-Dose Alkylating Chemotherapy in Patients with a BRCA1-like Breast CancerQ41073179
Dual-target inhibition of HIV-1 in vitro by means of an adeno-associated virus antisense vectorQ41590056
miR-221/222 targeting of trichorhinophalangeal 1 (TRPS1) promotes epithelial-to-mesenchymal transition in breast cancerQ42493425
Breast Cancer Vaccines: New InsightsQ42683276
Targeted therapy: tailoring cancer treatmentQ42857529
An elegant miRror: microRNAs in stem cells, developmental timing and cancerQ43140992
ABC transporters in cancer: more than just drug efflux pumps.Q43193922
Radiotherapy and survival in breast cancerQ43495597
Cisplatin versus carboplatin in combination with paclitaxel as neoadjuvant regimen for triple negative breast cancerQ47101500
Breast cancer statistics, 2017, racial disparity in mortality by state.Q47621558
Cytoprotective effects of endothelin-1 on mesenchymal stem cells: an in vitro study.Q47873444
Vaccination with p53-peptide-pulsed dendritic cells, of patients with advanced breast cancer: report from a phase I studyQ48032969
The tumor suppressor PTEN is exported in exosomes and has phosphatase activity in recipient cellsQ48362692
Buparlisib plus fulvestrant in postmenopausal women with hormone-receptor-positive, HER2-negative, advanced breast cancer progressing on or after mTOR inhibition (BELLE-3): a randomised, double-blind, placebo-controlled, phase 3 trial.Q49975220
Long-term survival after adoptive bone marrow T cell therapy of advanced metastasized breast cancer: follow-up analysis of a clinical pilot trial.Q50904556
Breast Cancer Immunotherapy.Q51108833
Toxicity, immunogenicity, and induction of E75-specific tumor-lytic CTLs by HER-2 peptide E75 (369-377) combined with granulocyte macrophage colony-stimulating factor in HLA-A2+ patients with metastatic breast and ovarian cancer.Q52009428
Breast cancer metastasis: Putative therapeutic role of vascular cell adhesion molecule-1.Q52094028
A step-by-step microRNA guide to cancer development and metastasis.Q52562647
The versatile role of exosomes in cancer progression: diagnostic and therapeutic implications.Q52581537
Altered primary chromatin structures and their implications in cancer development.Q52878923
Emerging diagnostic, prognostic and therapeutic biomarkers for ovarian cancer.Q52941950
MicroRNA-124 regulates neuronal differentiation of mesenchymal stem cells by targeting Sp1 mRNA.Q52978378
Fulvestrant with or without selumetinib, a MEK 1/2 inhibitor, in breast cancer progressing after aromatase inhibitor therapy: a multicentre randomised placebo-controlled double-blind phase II trial, SAKK 21/08.Q53535574
The lncRNA landscape of breast cancer reveals a role for DSCAM-AS1 in breast cancer progressionQ37315073
mTOR inhibitors, a new era for metastatic luminal HER2-negative breast cancer? A systematic review and a meta-analysis of randomized trialsQ37317165
Downregulation of LncRNA GAS5 causes trastuzumab resistance in breast cancerQ37317395
Circulating microRNAs (cmiRNAs) as novel potential biomarkers for hepatocellular carcinomaQ37406199
Controlled delivery of antisense oligonucleotides: a brief review of current strategies.Q37529859
LncRNA H19 confers chemoresistance in ERα-positive breast cancer through epigenetic silencing of the pro-apoptotic gene BIK.Q37697180
MicroRNAs--targeting and target predictionQ37706854
Subcellular fate and off-target effects of siRNA, shRNA, and miRNA.Q37950261
miR-221/222: promising biomarkers for breast cancerQ38093079
Targeting long non-coding RNA to therapeutically upregulate gene expressionQ38110692
Targeting long non-coding RNAs in cancers: progress and prospectsQ38113050
Farnesyltransferase inhibitors: a comprehensive review based on quantitative structural analysis.Q38140940
Immune modulation by chemotherapy or immunotherapy to enhance cancer vaccinesQ38161367
Recent insights into NF-κB signalling pathways and the link between inflammation and prostate cancerQ38161514
Targeting the BRCA1/2 tumor suppressorsQ38175472
Efficacy of biological agents in metastatic triple-negative breast cancerQ38188243
Multitargeted antiangiogenic tyrosine kinase inhibitors combined to chemotherapy in metastatic breast cancer: a systematic review and meta-analysisQ38190433
Targeting PI3K/Akt/mTOR Signaling in CancerQ38208314
Apoptosis and molecular targeting therapy in cancerQ38228349
Functional roles of long non-coding RNA in human breast cancerQ38240022
HER2-family signalling mechanisms, clinical implications and targeting in breast cancerQ38301236
MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1).Q38303663
Peptide nucleic acids targeting miR-221 modulate p27Kip1 expression in breast cancer MDA-MB-231 cellsQ38321556
Targeting BCL-2 to enhance vulnerability to therapy in estrogen receptor-positive breast cancer.Q38563530
A brief review on long noncoding RNAs: a new paradigm in breast cancer pathogenesis, diagnosis and therapyQ38667920
An immunogenic personal neoantigen vaccine for patients with melanomaQ38692859
Enhanced anti-tumor immunity against breast cancer induced by whole tumor cell vaccines genetically modified expressing α-Gal epitopesQ38737738
Targeting long non-coding RNA ASBEL with oligonucleotide antagonist for breast cancer therapyQ38759411
Therapeutic Targeting of miR-29b/HDAC4 Epigenetic Loop in Multiple Myeloma.Q38769965
Immunotherapy for the treatment of breast cancer: checkpoint blockade, cancer vaccines, and future directions in combination immunotherapyQ38785707
11 years' follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive early breast cancer: final analysis of the HERceptin Adjuvant (HERA) trialQ38953228
LncRNA HOTAIR enhances ER signaling and confers tamoxifen resistance in breast cancer.Q38991643
Cancer Statistics, 2017.Q39038674
MiR-200 can repress breast cancer metastasis through ZEB1-independent but moesin-dependent pathways.Q39095883
microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphomaQ33780259
Transcription Factor STAT3 as a Novel Molecular Target for Cancer PreventionQ33820278
The phosphoinositide-3-kinase-Akt-mTOR pathway as a therapeutic target in breast cancerQ33862290
Breathing new life into immunotherapy: review of melanoma, lung and kidney cancerQ33862861
Cancer targeted therapeutics: From molecules to drug delivery vehicles.Q33887986
Involvement of miR-326 in chemotherapy resistance of breast cancer through modulating expression of multidrug resistance-associated protein 1.Q33891809
Functional significance of macrophage-derived exosomes in inflammation and painQ33932873
miR-10b targets Tiam1: implications for Rac activation and carcinoma migrationQ33966873
Biological subtypes of breast cancer: Prognostic and therapeutic implicationsQ34023695
Cysteine-rich 61-connective tissue growth factor-nephroblastoma-overexpressed 5 (CCN5)/Wnt-1-induced signaling protein-2 (WISP-2) regulates microRNA-10b via hypoxia-inducible factor-1α-TWIST signaling networks in human breast cancer cellsQ34054835
MicroRNA-155 functions as an OncomiR in breast cancer by targeting the suppressor of cytokine signaling 1 geneQ34107532
Targeting microRNAs in cancer: rationale, strategies and challengesQ34141089
MicroRNA sequence and expression analysis in breast tumors by deep sequencingQ34185623
The inhibitory role of Mir-29 in growth of breast cancer cellsQ34249355
The immunosuppressive tumour network: myeloid-derived suppressor cells, regulatory T cells and natural killer T cellsQ34315871
p53 Family and Cellular Stress Responses in CancerQ34377287
Anti-miRNA oligonucleotides (AMOs): ammunition to target miRNAs implicated in human disease?Q34455538
Applications of the CRISPR-Cas9 system in cancer biologyQ34479139
Aromatase inhibitors versus tamoxifen in early breast cancer: patient-level meta-analysis of the randomised trialsQ34486930
Screening for Breast Cancer: U.S. Preventive Services Task Force Recommendation StatementQ34508652
Progestin suppression of miR-29 potentiates dedifferentiation of breast cancer cells via KLF4.Q34539750
Circulating microRNAs as specific biomarkers for breast cancer detection.Q34542335
CRISPR-mediated targeting of HER2 inhibits cell proliferation through a dominant negative mutation.Q34544137
New Immunotherapy Strategies in Breast CancerQ34549227
MicroRNAs in Cancer Biology and Therapy: Current Status and PerspectivesQ34599354
RNAi therapeutics: principles, prospects and challengesQ34621268
Target protectors reveal dampening and balancing of Nodal agonist and antagonist by miR-430.Q34673364
Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin.Q34798833
MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosisQ34835189
Phosphoglucose isomerase/autocrine motility factor mediates epithelial-mesenchymal transition regulated by miR-200 in breast cancer cellsQ34899974
Basal-like and triple-negative breast cancers: searching for positives among many negativesQ35005793
Knockdown of miR-21 in human breast cancer cell lines inhibits proliferation, in vitro migration and in vivo tumor growthQ35029501
Expression of two basic mRNA biomarkers in peripheral blood of patients with non-small cell lung cancer detected by real-time rt-PCR, individually and simultaneously.Q35065394
Concurrent chemoradiotherapy for locally advanced breast cancer-time for a new paradigm?Q35072438
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)605-621
P577publication date2018-09-27
P1433published inCellular OncologyQ2160503
P1476titleEmerging ways to treat breast cancer: will promises be met?
P478volume41

Reverse relations

cites work (P2860)
Q89639970Diagnostic value of an automated breast volume scanner compared with a hand-held ultrasound: a meta-analysis
Q92412493Knockdown of long noncoding RNA TP73-AS1 suppresses the malignant progression of breast cancer cells in vitro through targeting miRNA-125a-3p/metadherin axis
Q58553890Long non-coding RNAs as monitoring tools and therapeutic targets in breast cancer
Q60919599The Interleukin-17 Family of Cytokines in Breast Cancer

Search more.