Pathology of Calcineurin and Mammalian Target of Rapamycin Inhibitors in Kidney Transplantation

scholarly article by Rita Leal et al published March 2018 in KI reports

Pathology of Calcineurin and Mammalian Target of Rapamycin Inhibitors in Kidney Transplantation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.EKIR.2017.10.010
P932PMC publication ID6161639
P698PubMed publication ID30276344

P2093author name stringGeoffrey K Dube
Ibrahim Batal
Demetra Tsapepas
Lloyd Ratner
Russell J Crew
Rita Leal
P2860cites workTarget of rapamycin inhibitors (TOR-I; sirolimus and everolimus) for primary immunosuppression in kidney transplant recipientsQ24246340
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De novo thrombotic microangiopathy following treatment with sirolimus: report of two casesQ33364407
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Thrombotic microangiopathy after kidney transplantationQ33372586
De novo thrombotic microangiopathy. An underrated complication of renal transplantationQ33375722
Gene Expression in Biopsies of Acute Rejection and Interstitial Fibrosis/Tubular Atrophy Reveals Highly Shared Mechanisms That Correlate With Worse Long-Term Outcomes.Q33885388
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The histopathological changes associated with allograft rejection and drug toxicity in renal transplant recipients maintained on FK506. Clinical significance and comparison with cyclosporineQ35588481
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Chronic progressive calcineurin nephrotoxicity: an overstated conceptQ35929301
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Primer: Histopathology of calcineurin-inhibitor toxicity in renal allograftsQ36577199
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New insights into the pathophysiology of cyclosporine nephrotoxicity: a role of aldosterone.Q36788871
Oxidative stress as a common pathway to chronic tubulointerstitial injury in kidney allograftsQ36802004
High-dosage intravenous immunoglobulin-associated macrovacuoles are associated with chronic tubulointerstitial lesion worsening in renal transplant recipientsQ36843406
Osmotic nephrosis: acute kidney injury with accumulation of proximal tubular lysosomes due to administration of exogenous solutesQ37092612
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Evaluation of chronic renal disease in heart transplant recipients: importance of pretransplantation native kidney histologic evaluationQ72130385
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High sirolimus levels may induce focal segmental glomerulosclerosis de novoQ80797353
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Histological characteristics of calcineurin inhibitor toxicity--there is no such thing as specificity!Q84870341
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Influence of tacrolimus metabolism rate on renal function after solid organ transplantationQ37662992
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Regulation of innate immune cell function by mTOR.Q38592317
Targeting mTOR Signaling Can Prevent the Progression of FSGS.Q38922365
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Calcineurin Inhibitor Nephrotoxicity Through the Lens of Longitudinal Histology: Comparison of Cyclosporine and Tacrolimus ErasQ39680835
KDIGO clinical practice guideline for the care of kidney transplant recipientsQ39936865
Rapamycin inhibits PAI-1 expression and reduces interstitial fibrosis and glomerulosclerosis in chronic allograft nephropathyQ40025515
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Banff 07 classification of renal allograft pathology: updates and future directionsQ40121163
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Sirolimus and kidney growth in autosomal dominant polycystic kidney diseaseQ43004251
Apoptosis and adaptive responses to oxidative stress in human endothelial cells exposed to cyclosporin A correlate with BCL-2 expression levelsQ43548109
Chronic calcineurin inhibitor nephrotoxicity-lest we forgetQ43759235
Chronic cyclosporin nephropathy: long-term effects of cyclosporin on renal allograftsQ43854944
Sirolimus may promote thrombotic microangiopathyQ44326132
Delayed graft function and cast nephropathy associated with tacrolimus plus rapamycin use.Q44378937
Sirolimus therapy without calcineurin inhibitors: Necker Hospital 8-year experienceQ44437921
Increased risk of thrombotic microangiopathy in patients receiving a cyclosporin-sirolimus combinationQ44899011
Isometric tubular epithelial vacuolization in renal allograft biopsy specimens of patients receiving low-dose intravenous immunoglobulin for a positive crossmatchQ45077070
Rapamycin for focal segmental glomerulosclerosis: a report of 3 casesQ46079811
The TSC-mTOR signaling pathway regulates the innate inflammatory responseQ46321173
Sirolimus-induced thrombotic microangiopathy is associated with decreased expression of vascular endothelial growth factor in kidneysQ46702750
Post-transplantation proteinuria and sirolimusQ46799640
Proteinuria following a switch from calcineurin inhibitors to sirolimusQ46825307
Conversion from cyclosporine to sirolimus in stable renal transplant recipientsQ46863642
Hyalinosis Lesions in Renal Transplant Biopsies: Time-Dependent Complexity of InterpretationQ48206489
Is arteriolar vacuolization a predictor of calcineurin inhibitor nephrotoxicity?Q50534139
NFATc3 regulates Kv2.1 expression in arterial smooth muscle.Q50795101
Acute tubular necrosis associated with mTOR inhibitor therapy: a real entity biopsy-proven.Q50880766
Collapsing glomerulopathy in a renal transplant recipient: potential molecular mechanisms.Q51443976
The evolution of nonimmune histological injury and its clinical relevance in adult-sized kidney grafts in pediatric recipients.Q51740341
Reproducibility studies on arteriolar hyaline thickening scoring in calcineurin inhibitor-treated renal allograft recipients.Q53003709
International variation in histologic grading is large, and persistent feedback does not improve reproducibility.Q53301318
Cyclosporine-induced interstitial fibrosis and arteriolar TGF-beta expression with preserved renal blood flow.Q54067569
Effect of cyclosporine administration on renal hemodynamics in conscious rats.Q54441851
Activation of NFATc3 Down-regulates the β1 Subunit of Large Conductance, Calcium-activated K+Channels in Arterial Smooth Muscle and Contributes to HypertensionQ57396496
Efficacy of sirolimus compared with azathioprine for reduction of acute renal allograft rejection: a randomised multicentre studyQ57943257
The Banff 97 working classification of renal allograft pathologyQ59314413
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectpathologyQ7208
sirolimusQ32089
nephrologyQ177635
kidney transplantationQ740909
P304page(s)281-290
P577publication date2018-03-01
P1433published inKI reportsQ27727507
P1476titlePathology of Calcineurin and Mammalian Target of Rapamycin Inhibitors in Kidney Transplantation
P478volume3

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