Spotlight on lorlatinib and its potential in the treatment of NSCLC: the evidence to date

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Spotlight on lorlatinib and its potential in the treatment of NSCLC: the evidence to date is …
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scholarly articleQ13442814

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P356DOI10.2147/OTT.S165511
P932PMC publication ID6110295
P698PubMed publication ID30174447

P2093author name stringGouji Toyokawa
Takashi Seto
Tetsuzo Tagawa
Takaki Akamine
P2860cites workThe ALK Inhibitor Ceritinib Overcomes Crizotinib Resistance in Non-Small Cell Lung CancerQ27682565
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Sequential ALK Inhibitors Can Select for Lorlatinib-Resistant Compound ALK Mutations in ALK-Positive Lung CancerQ88345284
???Q27690215
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Clinical Experience With Crizotinib in Patients With Advanced ALK-Rearranged Non-Small-Cell Lung Cancer and Brain MetastasesQ35549714
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Comparative Efficacy of Ceritinib and Crizotinib as Initial ALK-Targeted Therapies in Previously Treated Advanced NSCLC: An Adjusted Comparison with External ControlsQ36049399
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P-glycoprotein Mediates Ceritinib Resistance in Anaplastic Lymphoma Kinase-rearranged Non-small Cell Lung CancerQ36538788
ALK Rearrangements Are Mutually Exclusive with Mutations in EGFR or KRAS: An Analysis of 1,683 Patients with Non–Small Cell Lung CancerQ37416902
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Alectinib versus Crizotinib in Untreated ALK-Positive Non-Small-Cell Lung Cancer.Q39354188
Multicenter Phase II Study of Whole-Body and Intracranial Activity With Ceritinib in Patients With ALK-Rearranged Non-Small-Cell Lung Cancer Previously Treated With Chemotherapy and Crizotinib: Results From ASCEND-2.Q39586490
The 15q24/25 susceptibility variant for lung cancer and chronic obstructive pulmonary disease is associated with emphysemaQ43223136
A novel fusion of TPR and ALK in lung adenocarcinomaQ46578009
Blood-brain barrier P-glycoprotein function decreases in specific brain regions with aging: a possible role in progressive neurodegenerationQ46688887
Osimertinib in Untreated EGFR-Mutated Advanced Non-Small-Cell Lung CancerQ47450132
Lorlatinib in non-small-cell lung cancer with ALK or ROS1 rearrangement: an international, multicentre, open-label, single-arm first-in-man phase 1 trialQ47599265
A prospective PCR-based screening for the EML4-ALK oncogene in non-small cell lung cancerQ48047005
P275copyright licenseCreative Commons Attribution-NonCommercial 3.0 UnportedQ18810331
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectlorlatinibQ27285820
P304page(s)5093-5101
P577publication date2018-01-01
P1433published inOncoTargets and TherapyQ7092081
P1476titleSpotlight on lorlatinib and its potential in the treatment of NSCLC: the evidence to date
P478volume11

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cites work (P2860)
Q64230139Comprehensive clinical implications of homeobox A10 in 3,199 cases of non-small cell lung cancer tissue samples combining qRT-PCR, RNA sequencing and microarray data
Q89622194Lorlatinib: an additional option for ALK-positive non-small cell lung cancer?
Q92236871Profile of alectinib for the treatment of ALK-positive non-small cell lung cancer (NSCLC): patient selection and perspectives
Q92184046Rapid regression of neurological symptoms in patients with metastasised ALK+ lung cancer who are treated with lorlatinib: a report of two cases
Q92141836Short progression-free survival of ALK inhibitors sensitive to secondary mutations in ALK-positive NSCLC patients

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