Animal Models for Preclinical Development of Allogeneic Hematopoietic Cell Transplantation

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Animal Models for Preclinical Development of Allogeneic Hematopoietic Cell Transplantation is …
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scholarly articleQ13442814

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P356DOI10.1093/ILAR/ILY006
P932PMC publication ID6808062
P698PubMed publication ID30010833

P50authorMaura H ParkerQ125344957
Rainer StorbQ19546769
P2093author name stringScott S Graves
P2860cites workPostgrafting immunosuppression with sirolimus and cyclosporine facilitates stable mixed hematopoietic chimerism in dogs given sublethal total body irradiation before marrow transplantation from DLA-identical littermatesQ44557802
Fractionated total body irradiation and autologous bone marrow transplantation in dogs: hemopoietic recovery after various marrow cell doses.Q44850685
Addition of interleukin-6 inhibition with tocilizumab to standard graft-versus-host disease prophylaxis after allogeneic stem-cell transplantation: a phase 1/2 trial.Q45050218
Phase II Study of Sequential Infusion of Donor Lymphocyte Infusion and Cytokine-Induced Killer Cells for Patients Relapsed after Allogeneic Hematopoietic Stem Cell Transplantation.Q45869798
Isolation and characterization of pediatric canine bone marrow CD34+ cellsQ45876694
CD28 costimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of adoptively transferred T cells.Q45984095
Vorinostat plus tacrolimus/methotrexate to prevent GVHD after myeloablative conditioning, unrelated donor HCT.Q47104749
Single dose or fractionated total body irradiation and autologous marrow transplantation in dogs: effects of exposure rate, fraction size, and fractionation interval on acute and delayed toxicityQ47178151
Recipient CD4+ T cells that survive irradiation regulate chronic graft-versus-host diseaseQ47586153
Donor CD4+ T and B cells in transplants induce chronic graft-versus-host disease with autoimmune manifestationsQ47605536
Lymphocyte typing in allografted beaglesQ47805701
Marrow grafts by combined marrow and leukocyte infusions in unrelated dogs selected by histocompatibility typingQ47808575
Cytotoxic typing antisera for marrow grafting in littermate dogsQ47816843
Molecular analysis and polymorphism of the DLA-DQB genesQ48010732
Hematopoietic-cell transplantation at 50.Q48546980
In-vivo or ex-vivo T cell depletion or both to prevent graft-versus-host disease after hematopoietic stem cell transplantation.Q48680865
Anti-Inducible Costimulator Monoclonal Antibody Treatment of Canine Chronic Graft-versus-Host DiseaseQ49662013
Autologous T Cells Expressing CD30 Chimeric Antigen Receptors for Relapsed or Refractory Hodgkin Lymphoma: An Open-Label Phase I TrialQ50040577
Revamp animal research rules, report urgesQ50092299
Targeting of inducible costimulator (ICOS) expressed on alloreactive T cells down-regulates graft-versus-host disease (GVHD) and facilitates engraftment of allogeneic bone marrow (BM).Q50782599
TNF-TNFR2 interactions are critical for the development of intestinal graft-versus-host disease in MHC class II-disparate (C57BL/6J-->C57BL/6J x bm12)F1 mice.Q52014017
Failure of allogeneic canine marrow grafts after total-body irradiation. Allogeneic "resistance" versus transfusion-induced sensitization.Q52136176
Long-term outcome and late effects in patients transplanted with mobilised blood or bone marrow: a randomised trial.Q52905842
Opposing effects of ICOS on graft-versus-host disease mediated by CD4 and CD8 T cells.Q53619773
Marrow Infusions in Dogs Given Midlethal or Lethal IrradiationQ53759962
A phase I/II double-blind, placebo-controlled study of recombinant human interleukin-11 for mucositis and acute GVHD prevention in allogeneic stem cell transplantation.Q53975414
Chronic graft-versus-host syndrome in man. A long-term clinicopathologic study of 20 Seattle patients.Q54684597
Treatment of murine leukaemia with X rays and homologous bone marrow; preliminary communication.Q55510169
JTA-009, a fully human antibody against human AILIM/ICOS, ameliorates graft-vs-host reaction in SCID mice grafted with human PBMCsQ56900336
Cytotoxic T lymphocyte antigen 4-immunoglobulin fusion protein combined with methotrexate/cyclosporine as graft-versus-host disease prevention in a canine dog leukocyte antigen-nonidentical marrow transplant modelQ56906237
Chronic graft-versus-host disease after allogeneic blood stem cell transplantation: long-term results of a randomized studyQ78385763
[Trial therapy, by x-irradiation followed by the administration of homologous bone marrow cells, of highly-advanced spontaneous leukemia in AK mice.]Q78467291
Donor T cell-derived TNF is required for graft-versus-host disease and graft-versus-tumor activity after bone marrow transplantationQ78494858
Pathological changes in F1 hybrid mice following transplantation of spleen cells from donors of the parental strainsQ78651273
Value of bone marrow and spleen cell suspensions for survival of lethally irradiated dogsQ79280034
Marrow transplants in lethally irradiated dogs given methotrexateQ79428981
Predictive value of p16 or Rb inactivation in a model of naturally occurring canine non-Hodgkin's lymphomaQ80313398
CD20 expression in normal canine B cells and in canine non-Hodgkin lymphomaQ80352090
An improved method for dog leukocyte antigen 88 typing and two new major histocompatibility complex class I alleles, DLA-88*01101 and DLA-88*01201Q80456836
Expanded donor natural killer cell and IL-2, IL-15 treatment efficacy in allogeneic hematopoietic stem cell transplantationQ81506471
Filgrastim-mobilized peripheral blood progenitor cells versus bone marrow transplantation for treating leukemia: 3-year results from the EBMT randomized trialQ81793164
Sudden loss of the GVL effect following use of the TNF inhibitor infliximab in a chronic myelogenous leukemia patient with chronic GVHDQ84700524
Activity of therapeutic JAK 1/2 blockade in graft-versus-host diseaseQ87635679
Treatment of CD20-directed Chimeric Antigen Receptor-modified T cells in patients with relapsed or refractory B-cell non-Hodgkin lymphoma: an early phase IIa trial reportQ89700420
Effect of graft-versus-host disease prophylaxis on 3-year disease-free survival in recipients of unrelated donor bone marrow (T-cell Depletion Trial): a multi-centre, randomised phase II-III trialQ34446176
Intestinal graft-versus-host disease is initiated by donor T cells distinct from classic cytotoxic T lymphocytesQ34581469
Interleukin-6 Modulates Graft-versus-Host Responses after Experimental Allogeneic Bone Marrow TransplantationQ34683729
A compendium of reported human bone marrow transplantsQ34700669
Roles of CD28, CTLA4, and inducible costimulator in acute graft-versus-host disease in miceQ35092307
Cytotoxic T lymphocytes with a grafted recognition specificity for ERBB2-expressing tumor cellsQ35227334
Antagonistic and agonistic anti-canine CD28 monoclonal antibodies: tools for allogeneic transplantationQ35234495
Anti-CD28 Antibody-Initiated Cytokine Storm in CaninesQ35610659
Adoptive T-cell therapy improves treatment of canine non-Hodgkin lymphoma post chemotherapyQ35752854
Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliteransQ35776453
Characterization of target injury of murine acute graft-versus-host disease directed to multiple minor histocompatibility antigens elicited by either CD4+ or CD8+ effector cellsQ35830507
Long-term outcome of patients given transplants of mobilized blood or bone marrow: A report from the International Bone Marrow Transplant Registry and the European Group for Blood and Marrow TransplantationQ35848787
Acute and chronic graft-versus-host disease in dogs given hemopoietic grafts from DLA-nonidentical littermates. Two distinct syndromesQ35885125
Development of a Minor Histocompatibility Antigen Vaccine Regimen in the Canine Model of Hematopoietic Cell TransplantationQ36113141
Allosuppressor and allohelper T cells in acute and chronic graft-vs.-host disease. II. F1 recipients carrying mutations at H-2K and/or I-AQ36347506
Transplant tolerance in non-human primates: progress, current challenges and unmet needsQ36447590
Anti-CD45 radioimmunotherapy without TBI before transplantation facilitates persistent haploidentical donor engraftmentQ36488985
Murine models of chronic graft-versus-host disease: insights and unresolved issuesQ36645730
Enhancement of GVL effect with rhIL-2 following BMT in a murine model for acute myeloid leukemia in SJL/J miceQ36718005
Graft-versus-host disease and graft-versus-tumor effects after allogeneic hematopoietic cell transplantationQ36763834
Molecular analysis and polymorphism of the DLA-DQA geneQ36830133
Molecular analysis of the DLA DR regionQ36841269
Concise review: acute graft-versus-host disease: immunobiology, prevention, and treatmentQ36861714
Ruxolitinib in corticosteroid-refractory graft-versus-host disease after allogeneic stem cell transplantation: a multicenter surveyQ36862931
CD19 CAR-T cells of defined CD4+:CD8+ composition in adult B cell ALL patientsQ36951727
Inducible costimulator (ICOS) up-regulation on activated T cells in chronic graft-versus-host disease after dog leukocyte antigen-nonidentical hematopoietic cell transplantation: a potential therapeutic targetQ36966278
Pharmacologic prophylaxis regimens for acute graft-versus-host disease: past, present and futureQ36980277
Adoptive immunotherapy against allogeneic kidney grafts in dogs with stable hematopoietic trichimerismQ37016470
Preclinical models of acute and chronic graft-versus-host disease: how predictive are they for a successful clinical translation?Q37035815
Mouse models of bone marrow transplantationQ37045969
Graft failure after allogeneic hematopoietic cell transplantationQ37045988
Histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces acute graft-versus-host disease and preserves graft-versus-leukemia effectQ37095317
Initial therapy of acute graft-versus-host disease with low-dose prednisone does not compromise patient outcomesQ37143633
Blockade of interleukin-6 signaling augments regulatory T-cell reconstitution and attenuates the severity of graft-versus-host disease.Q37275902
Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase–dependent DC functions and regulates experimental graft-versus-host disease in miceQ24288997
Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantationQ24626051
Nonmyeloablative allogeneic hematopoietic cell transplantationQ26748780
Immuno-intervention for the induction of transplantation tolerance through mixed chimerismQ27001243
Radioimmunotherapy of human tumoursQ28088825
The canine genomeQ28285982
Use of multigeneration-family molecular dog leukocyte antigen typing to select a hematopoietic cell transplant donor for a dog with T-cell lymphomaQ28299569
Chimeric antigen receptor T cells for sustained remissions in leukemiaQ29617588
Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancerQ29619483
Allogeneic peripheral blood stem-cell compared with bone marrow transplantation in the management of hematologic malignancies: an individual patient data meta-analysis of nine randomized trialsQ30997153
Organization of the canine major histocompatibility complex: current perspectivesQ31905980
Pilot study of a (213)bismuth-labeled anti-CD45 mAb as a novel nonmyeloablative conditioning for DLA-haploidentical littermate hematopoietic transplantationQ33388983
Durable donor engraftment after radioimmunotherapy using α-emitter astatine-211-labeled anti-CD45 antibody for conditioning in allogeneic hematopoietic cell transplantationQ33398529
Vorinostat plus tacrolimus and mycophenolate to prevent graft-versus-host disease after related-donor reduced-intensity conditioning allogeneic haemopoietic stem-cell transplantation: a phase 1/2 trialQ33411822
Identification of MHC II-Restricted Minor Histocompatibility Antigens After HLA-Identical Stem-Cell TransplantationQ33677067
IL-11 separates graft-versus-leukemia effects from graft-versus-host disease after bone marrow transplantation.Q33853636
Differential roles of IL-1 and TNF-alpha on graft-versus-host disease and graft versus leukemiaQ33857573
NK cells mediate reduction of GVHD by inhibiting activated, alloreactive T cells while retaining GVT effectsQ33887452
Insights into morphology and disease from the dog genome projectQ33904330
Spontaneously occurring tumors of companion animals as models for human cancerQ33927360
A phase III study of infliximab and corticosteroids for the initial treatment of acute graft-versus-host diseaseQ33964687
Intravenous infusion of bone marrow in patients receiving radiation and chemotherapyQ33969561
Large animal models of hematopoietic stem cell gene therapyQ34039922
Supralethal whole body irradiation and isologous marrow transplantation in man.Q34250866
An MHC-Defined Primate Model Reveals Significant Rejection of Bone Marrow After Mixed Chimerism Induction Despite Full MHC MatchingQ34307416
Acute and chronic graft-versus-host disease after allogeneic peripheral-blood stem-cell and bone marrow transplantation: a meta-analysisQ34337007
A minor transplantation antigen detected by MHC-restricted cytotoxic T lymphocytes during graft-versus-host diseaseQ59065980
Pharmacologic, toxicologic, and marrow transplantation studies in dogs given succinyl acetoneQ67585400
Use of recombinant human interleukin-2 in conjunction with bone marrow transplantation as a model for control of minimal residual disease in malignant hematological disorders: I. Treatment of murine leukemia in conjunction with allogeneic bone marroQ67741731
Inhibition of interleukin-1 by an interleukin-1 receptor antagonist prevents graft-versus-host diseaseQ67903035
Prevention of graft-versus-host disease by immunosuppressive agents after transplantation of DLA-nonidentical canine marrowQ68242113
Methotrexate regimens for control of graft-versus-host disease in dogs with allogeneic marrow graftsQ68743119
Marrow transplantation for severe aplastic anemia: methotrexate alone compared with a combination of methotrexate and cyclosporine for prevention of acute graft-versus-host diseaseQ68882743
Marrow grafts between histoincompatible canine family membersQ69233061
Antithymocyte serum and methotrexate for control of graft-versus-host disease in dogsQ69273159
Immunologic, toxicologic and marrow transplantation studies in dogs given dimethyl myleranQ69365561
Antibody-radionuclide conjugates as part of a myeloablative preparative regimen for marrow transplantationQ69506136
Autologous bone marrow grafts in dogs treated with lethal doses of cyclophosphamideQ69873751
Allogeneic canine bone marrow transplantation following cyclophosphamideQ69876471
The repopulation of irradiated bone marrow by the infusion of stored autologous marrowQ69897397
Transplantation of stored allogeneic bone marrow in dogs selected by histocompatibility typingQ69907310
Autologous marrow transplantation as consolidation therapy for canine lymphoma: efficacy and toxicity of various regimens of total body irradiationQ69912101
Radioimmunotherapy with alpha-particle-emitting immunoconjugatesQ69918183
Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A-matched sibling donorsQ70051817
Cyclosporin-A: effect on marrow engraftment and graft-versus-host disease in dogsQ70172378
High-dose total-body irradiation and autologous marrow reconstitution in dogs: dose-rate-related acute toxicity and fractionation-dependent long-term survivalQ70192594
What radiation dose for DLA-identical canine marrow grafts?Q70213348
Combined immunosuppression with cyclosporine and methotrexate in dogs given bone marrow grafts from DLA-haploidentical littermatesQ70318454
Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cellQ71142561
Adoptive immunotherapy of acute leukemia: experimental and clinical resultsQ71170609
Tacrolimus (FK506) and methotrexate regimens to prevent graft-versus-host disease after unrelated dog leukocyte antigen (DLA) nonidentical marrow transplantationQ71299277
Cyclosporin A and methotrexate in canine marrow transplantation: engraftment, graft-versus-host disease, and induction of intoleranceQ71442356
A clinical phase I/II study of recombinant human interleukin-1 receptor in glucocorticoid-resistant graft-versus-host diseaseQ71588928
FK-506 and methotrexate prevent graft-versus-host disease in dogs given 9.2 Gy total body irradiation and marrow grafts from unrelated dog leukocyte antigen-nonidentical donorsQ72100042
Stable mixed hematopoietic chimerism in DLA-identical littermate dogs given sublethal total body irradiation before and pharmacological immunosuppression after marrow transplantationQ73235565
Prevention of irradiation-induced lymphoid tumors in C57BL mice by spleen protectionQ73298607
Humoral factor in irradiation protection: modification of lethal irradiation injury in mice by injection of rat bone marrowQ73384569
Analysis of immunodominance among minor histocompatibility antigens in allogeneic hematopoietic stem cell transplantationQ73398048
Transplantation of bone marrow as compared with peripheral-blood cells from HLA-identical relatives in patients with hematologic cancersQ73427004
The role of disease stage in the response to donor lymphocyte infusions as treatment for leukemic relapseQ73533291
Effects of non-major histocompatibility antigens on acute graft-versus-host reaction after allogeneic bone marrow transplantationQ73670153
Successful skin homografts after the administration of high dosage X radiation and homologous bone marrowQ73726902
Adoptive immunotherapy in canine mixed chimeras after nonmyeloablative hematopoietic cell transplantationQ73783372
Mixed chimerism in the B cell lineage is a rapid and sensitive indicator of minimal residual disease in bone marrow transplant recipients with pre-B cell acute lymphoblastic leukemiaQ73784852
Parotid salivary gland dysfunction in chronic graft-versus-host disease (cGVHD): a longitudinal study in a mouse modelQ73828922
Mortality and skin transplantability in x-irradiated mice receiving isologous, homologous or heterologous bone marrowQ74268409
Synergism between mycophenolate mofetil and cyclosporine in preventing graft-versus-host disease among lethally irradiated dogs given DLA-nonidentical unrelated marrow graftsQ74357436
Comparison of chronic graft-versus-host disease after transplantation of peripheral blood stem cells versus bone marrow in allogeneic recipients: long-term follow-up of a randomized trialQ74389035
Treatment of murine leukaemia with x-rays and homologous bone marrow. IIQ74602320
Modification of irradiation injury in mice and guinea pigs by bone marrow injectionsQ75832754
Opposing effects of anti-activation-inducible lymphocyte-immunomodulatory molecule/inducible costimulator antibody on the development of acute versus chronic graft-versus-host diseaseQ77136941
Stable mixed hematopoietic chimerism in dog leukocyte antigen-identical littermate dogs given lymph node irradiation before and pharmacologic immunosuppression after marrow transplantationQ78039826
Comparing high and low total body irradiation dose rates for minimum-intensity conditioning of dogs for dog leukocyte antigen-identical bone marrow graftsQ37287517
Transmission and expansion of HOXB4-induced leukemia in two immunosuppressed dogs: implications for a new canine leukemia modelQ37357517
Interleukin-11 promotes T cell polarization and prevents acute graft-versus-host disease after allogeneic bone marrow transplantation.Q37387081
Pathophysiology of GvHD and Other HSCT-Related Major ComplicationsQ37710572
Mouse models of graft-versus-host disease: advances and limitationsQ37874011
A model of study for human cancer: Spontaneous occurring tumors in dogs. Biological features and translation for new anticancer therapies.Q38096524
Advances in the development of animal models of myeloid leukemiasQ38161668
Systems biology of primary CNS lymphoma: from genetic aberrations to modeling in miceQ38163336
Preclinical modeling of hematopoietic stem cell transplantation - advantages and limitationsQ38660463
How important is histocompatibility in bone marrow transplantation?Q38687869
Feasibility and Safety of RNA-transfected CD20-specific Chimeric Antigen Receptor T Cells in Dogs with Spontaneous B Cell Lymphoma.Q38758789
A Canine Model of Chronic Graft-versus-Host DiseaseQ38778387
Myeloablative Versus Reduced-Intensity Hematopoietic Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic SyndromesQ38852431
Canine allogeneic bone marrow transplantation. Technique and variables influencing engraftmentQ39114914
Hemopoietic grafts between DLA-identical canine littermates following dimethyl myleran. Evidence for resistance to grafts not associated with DLA and abrogated by antithymocyte serumQ39170481
Graft-versus-host disease in dog and man: the Seattle experienceQ39839309
Therapy of advanced B-lymphoma xenografts with a combination of 90Y-anti-CD22 IgG (epratuzumab) and unlabeled anti-CD20 IgG (veltuzumab).Q39933579
Effects of HOXB4 overexpression on ex vivo expansion and immortalization of hematopoietic cells from different speciesQ40131427
T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trialQ40186710
The Knife's Edge of Tolerance: Inducing Stable Multilineage Mixed Chimerism but With a Significant Risk of CMV Reactivation and Disease in Rhesus MacaquesQ40584637
Prevention and treatment of relapse by bone marrow transplantation.Q40723052
Murine monoclonal anti-T cell antibodies for treatment of steroid-resistant acute graft-versus-host diseaseQ40831481
Treatment of severe aplastic anemia using antithymocyte globulin with or without an infusion of HLA haploidentical marrow.Q40851391
Study of cell dose and storage time on engraftment of cryopreserved autologous bone marrow in a canine modelQ40950055
Combination Therapy with Inolimomab and Etanercept for Severe Steroid-Refractory Acute Graft-versus-Host DiseaseQ40991233
Prolonged disease-free survival in dogs with lymphoma after total-body irradiation and autologous marrow transplantation consolidation of combination-chemotherapy-induced remissionsQ41116466
Dose rate and dose fractionation studies in total body irradiation of dogsQ41122502
Total body irradiation and autologous marrow transplantation as consolidation therapy for spontaneous canine lymphoma in remissionQ41210282
Hemopoietic reconstitution following autologous bone marrow and peripheral blood mononuclear cell infusionsQ41210500
The CD28-B7 costimulatory pathway and its role in autoimmune disease.Q41567048
AN ASSAY OF GRAFT-HOST INTERACTIONS ACROSS STRONG AND WEAK HISTOCOMPATIBILITY BARRIERS IN MICEQ41966133
Bcr-Abl efficiently induces a myeloproliferative disease and production of excess interleukin-3 and granulocyte-macrophage colony-stimulating factor in mice: a novel model for chronic myelogenous leukemiaQ42824835
Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivoQ42938990
T-cell depletion of HLA-identical transplants in leukemia.Q43844182
Methotrexate and cyclosporine compared with cyclosporine alone for prophylaxis of acute graft versus host disease after marrow transplantation for leukemiaQ44237334
Selective T-cell ablation with bismuth-213-labeled anti-TCRalphabeta as nonmyeloablative conditioning for allogeneic canine marrow transplantationQ44333081
IL-2 does not enhance the conversion to complete donor chimerism following nonmyeloablative hematopoietic cell transplantation in dogsQ44458201
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)263-275
P577publication date2018-12-01
P1433published inILAR JournalQ15756706
P1476titleAnimal Models for Preclinical Development of Allogeneic Hematopoietic Cell Transplantation
P478volume59

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Q99566339Induction of Tolerance Towards Solid Organ Allografts Using Hematopoietic Cell Transplantation in Large Animal Modelscites workP2860

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