Renal Cell Carcinoma: Molecular Aspects

scientific article published on 13 November 2017

Renal Cell Carcinoma: Molecular Aspects is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S12291-017-0713-Y
P932PMC publication ID6052717
P698PubMed publication ID30072823

P50authorRajendra PrasadQ90724965
P2093author name stringAman Kumar
Niti Kumari
Vinny Gupta
P2860cites workStructure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor functionQ22009393
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysisQ22009936
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinomaQ24337664
Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau proteinQ24563543
The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteinsQ24564802
Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complexQ24655274
A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell CarcinomaQ27728074
Adverse outcomes in clear cell renal cell carcinoma with mutations of 3p21 epigenetic regulators BAP1 and SETD2: a report by MSKCC and the KIRC TCGA research networkQ27852242
Integrated molecular analysis of clear-cell renal cell carcinomaQ27852382
Targeting HIF-1 for cancer therapyQ27860504
Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genesQ29615757
Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau proteinQ29615928
Identification of the von Hippel-Lindau disease tumor suppressor geneQ29618644
The sonic hedgehog signaling pathway is reactivated in human renal cell carcinoma and plays orchestral role in tumor growthQ33578572
Molecular genetics of clear-cell renal cell carcinomaQ33729097
Concurrent CD44s and STAT3 expression in human clear cell renal cellular carcinoma and its impact on survivalQ33898664
Mechanism of von Hippel-Lindau protein-mediated suppression of nuclear factor kappa B activityQ33925065
NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1.Q33959017
Mammalian Target of Rapamycin Inhibitors Resistance Mechanisms in Clear Cell Renal Cell CarcinomaQ34077263
microRNA-21 Governs TORC1 Activation in Renal Cancer Cell Proliferation and InvasionQ34299534
Searching for the hereditary causes of renal-cell carcinomaQ34318015
Identification of deregulated oncogenic pathways in renal cell carcinoma: an integrated oncogenomic approach based on gene expression profilingQ34576344
Expression of the von Hippel-Lindau disease tumour suppressor gene during human embryogenesisQ34734132
Meta-analysis identifies NF-κB as a therapeutic target in renal cancerQ35014835
The genetic basis of renal cell carcinomaQ35210970
Genetic and Functional Studies Implicate HIF1α as a 14q Kidney Cancer Suppressor GeneQ35452783
Enhanced IMP3 Expression Activates NF-кB Pathway and Promotes Renal Cell Carcinoma ProgressionQ35546846
Characterization of VHL missense mutations in sporadic clear cell renal cell carcinoma: hotspots, affected binding domains, functional impact on pVHL and therapeutic relevanceQ36105139
Targeting the HGF/Met signalling pathway in cancer.Q36142604
Mutations in BHD and TP53 genes, but not in HNF1beta gene, in a large series of sporadic chromophobe renal cell carcinomaQ36609752
The VHL/HIF axis in clear cell renal carcinomaQ36872295
Actuality of Warburg's views in our understanding of renal cancer metabolism.Q36897159
Hypoxia, Hypoxia-inducible Transcription Factors, and Renal CancerQ37234734
Phase I dose-escalation study of EZN-2208 (PEG-SN38), a novel conjugate of poly(ethylene) glycol and SN38, administered weekly in patients with advanced cancerQ37339628
Patterns of gene expression and copy-number alterations in von-hippel lindau disease-associated and sporadic clear cell carcinoma of the kidneyQ37349768
A study exploring critical pathways in clear cell renal cell carcinomaQ37388562
STAT3 and HIF1α cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cellsQ37404757
2009 update on the classification of renal epithelial tumors in adultsQ37488430
Galectin-1 has potential prognostic significance and is implicated in clear cell renal cell carcinoma progression through the HIF/mTOR signaling axisQ37632111
Targeting renal cell carcinoma with a HIF-2 antagonist.Q37684974
Wide spetcrum mutational analysis of metastatic renal cell cancer: a retrospective next generation sequencing approachQ37702516
VHL and HIF signalling in renal cell carcinogenesisQ37708208
Molecular aspects of renal cell carcinoma: a reviewQ37942072
A phase I study of cabozantinib (XL184) in patients with renal cell cancer.Q38430335
VHL promotes immune response against renal cell carcinoma via NF-κB-dependent regulation of VCAM-1.Q38714947
PBRM1 (BAF180) protein is functionally regulated by p53-induced protein degradation in renal cell carcinomasQ38852640
HAVCR/KIM-1 activates the IL-6/STAT-3 pathway in clear cell renal cell carcinoma and determines tumor progression and patient outcome.Q39037287
Pilot trial of EZN-2968, an antisense oligonucleotide inhibitor of hypoxia-inducible factor-1 alpha (HIF-1α), in patients with refractory solid tumorsQ39051622
Loss of PBRM1 expression is associated with renal cell carcinoma progressionQ39285387
A proteomic analysis reveals the loss of expression of the cell death regulatory gene GRIM-19 in human renal cell carcinomasQ40274291
Efficacy of the nanoparticle-drug conjugate CRLX101 in combination with bevacizumab in metastatic renal cell carcinoma: results of an investigator-initiated phase I-IIa clinical trialQ40600188
Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL.Q40633683
Hereditary Renal-Cell Carcinoma Associated with a Chromosomal TranslocationQ41751694
The apoptosis repressor with a CARD domain (ARC) gene is a direct hypoxia-inducible factor 1 target gene and promotes survival and proliferation of VHL-deficient renal cancer cellsQ41908755
Effects of HIF-1alpha and HIF2alpha on Growth and Metabolism of Clear-Cell Renal Cell Carcinoma 786-0 XenograftsQ42726487
HGF/c-Met Acts as an Alternative Angiogenic Pathway in Sunitinib-Resistant TumorsQ42819341
Genomic profiling of the genes on chromosome 3p in sporadic clear cell renal cell carcinomaQ46635938
Reciprocal regulation of hypoxia-inducible factor 2α and GLI1 expression associated with the radioresistance of renal cell carcinomaQ51018011
Loss of tumor suppressor protein PTEN during renal carcinogenesisQ53390981
The Heidelberg classification of renal cell tumoursQ55067278
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectrenal cell carcinomaQ1164529
P304page(s)246-254
P577publication date2017-11-13
P1433published inIndian journal of clinical biochemistryQ26853918
P1476titleRenal Cell Carcinoma: Molecular Aspects
P478volume33

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cites work (P2860)
Q92201027Decreased expression of SLC16A12 mRNA predicts poor prognosis of patients with clear cell renal cell carcinoma
Q92151949GSTO1*CC Genotype (rs4925) Predicts Shorter Survival in Clear Cell Renal Cell Carcinoma Male Patients
Q64266350HSP60 silencing promotes Warburg-like phenotypes and switches the mitochondrial function from ATP production to biosynthesis in ccRCC cells
Q112642167LncRNA TCF7 Promotes Epithelial Ovarian Cancer Viability, Mobility and Stemness via Regulating ITGB8
Q92053247Pathogenic and Therapeutic Role of H3K4 Family of Methylases and Demethylases in Cancers
Q98290256Pituitary Metastatic Composite Tumors: A Case Report with Next-Generation Sequencing and Review of the Literature
Q90437295Prognostic role of S100A9 expression in patients with clear cell renal cell carcinoma
Q90273767Ubiquitin-specific protease-44 inhibits the proliferation and migration of cells via inhibition of JNK pathway in clear cell renal cell carcinoma