Rho and Rac, but not ROCK, are required for secretion of human and mouse eosinophil-associated RNases

scientific article published on 19 November 2018

Rho and Rac, but not ROCK, are required for secretion of human and mouse eosinophil-associated RNases is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/CEA.13292
P932PMC publication ID6353669
P698PubMed publication ID30295352

P50authorRevital ShamriQ92114325
P2093author name stringPeter F Weller
Kristen M Young
P2860cites workActivation of Rhoa and ROCK are essential for detachment of migrating leukocytesQ24555685
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RhoA/Rho-kinase as a therapeutic target in asthmaQ28300192
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Eosinophil extracellular DNA trap cell death mediates lytic release of free secretion-competent eosinophil granules in humans.Q30537562
IL-5 induces suspended eosinophils to undergo unique global reorganization associated with primingQ33799642
Agonist activation of f-actin-mediated eosinophil shape change and mediator release is dependent on Rac2.Q35016132
CXCL9 inhibits eosinophil responses by a CCR3- and Rac2-dependent mechanismQ35847956
CCL11 elicits secretion of RNases from mouse eosinophils and their cell-free granulesQ35913057
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Rho kinase inhibitors: a novel therapeutical intervention in asthma?Q37138171
Intragranular vesiculotubular compartments are involved in piecemeal degranulation by activated human eosinophils.Q37274179
Airway eosinophils: allergic inflammation recruited professional antigen-presenting cellsQ37327205
Mitogen-activated protein kinase/extracellular signal-regulated kinase 2 regulates cytoskeletal organization and chemotaxis via catalytic and microtubule-specific interactionsQ37386319
Basal extracellular signal-regulated kinase activity modulates cell-cell and cell-matrix interactionsQ39574801
Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases.Q40068834
Requirement for RhoA kinase activation in leukocyte de-adhesionQ40708953
Primary granule exocytosis in human neutrophils is regulated by Rac-dependent actin remodelingQ40822164
PI3K, ERK, p38 MAPK and integrins regulate CCR3-mediated secretion of mouse and human eosinophil-associated RNasesQ42024121
Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinasesQ42802765
The functional role of rho and rho-associated coiled-coil forming protein kinase in eotaxin signaling of eosinophilsQ43760136
CCL11 and GM-CSF differentially use the Rho GTPase pathway to regulate motility of human eosinophils in a three-dimensional microenvironmentQ46560042
The inhaled Rho kinase inhibitor Y-27632 protects against allergen-induced acute bronchoconstriction, airway hyperresponsiveness, and inflammationQ46589827
A rho kinase inhibitor, Y-27632 inhibits pulmonary eosinophilia, bronchoconstriction and airways hyperresponsiveness in allergic miceQ47877597
Evaluation of Y-27632, a rho-kinase inhibitor, as a bronchodilator in guinea pigs.Q54034457
Rho Controls Cortical F-actin Disassembly in Addition to, but Independently of, Secretion in Mast CellsQ61896874
CD11b/CD18 (Mac-1) is required for degranulation of human eosinophils induced by human recombinant granulocyte-macrophage colony-stimulating factor and platelet-activating factorQ71624306
Intercellular adhesion molecule-1 on eosinophils is involved in eosinophil protein X release induced by cytokinesQ73307210
Cutting edge: eotaxin elicits rapid vesicular transport-mediated release of preformed IL-4 from human eosinophilsQ73720769
Activation of mitogen-activated protein kinase regulates eotaxin-induced eosinophil migrationQ78025475
Effects of Rho-kinase inactivation on eosinophilia and hyper-reactivity in murine airways by allergen challengesQ80149702
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)190-198
P577publication date2018-11-19
P1433published inClinical & Experimental AllergyQ5133747
P1476titleRho and Rac, but not ROCK, are required for secretion of human and mouse eosinophil-associated RNases
P478volume49