Glucose homeostasis dependency on acini-islet-acinar (AIA) axis communication: a new possible pathophysiological hypothesis regarding diabetes mellitus

scientific article published on 8 October 2018

Glucose homeostasis dependency on acini-islet-acinar (AIA) axis communication: a new possible pathophysiological hypothesis regarding diabetes mellitus is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1038/S41387-018-0062-9
P932PMC publication ID6174155
P698PubMed publication ID30293998

P50authorJarosław WolińskiQ57025744
Kateryna Goncharova PierzynowskaQ59706356
Rafał FilipQ90449158
P2093author name stringStefan G Pierzynowski
Peter C Gregory
P2860cites workCarbohydrate intake and overweight and obesity among healthy adultsQ24634103
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Suppression of Ptf1a activity induces acinar-to-endocrine conversion.Q33874704
Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeoverQ34244209
Reprogramming of human pancreatic exocrine cells to β-like cells.Q34452113
Low serum amylase in association with metabolic syndrome and diabetes: A community-based studyQ35009097
Pancreatic and pancreatic-like microbial proteases accelerate gut maturation in neonatal ratsQ35057742
Glucagon-like Peptide 1 Receptor Signaling in Acinar Cells Causes Growth-Dependent Release of Pancreatic Enzymes.Q51265443
Decreased insulin secretion and glucose clearance in exocrine pancreas-insufficient pigs.Q51292778
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Bacterial “Glycogen” and SurvivalQ52750412
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Increased postprandial responses of GLP-1 and GIP in patients with chronic pancreatitis and steatorrhea following pancreatic enzyme substitutionQ58168549
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Insulin and the parasympathetic dependence of pancreatic juice secretion in healthy and alloxan diabetic sheepQ68903907
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Plasma Immunoreactive Pancreatic Cationic Trypsinogen in Cystic Fibrosis: a Sensitive Indicator of Exocrine Pancreatic DysfunctionQ70983685
Inhibition of exocrine pancreatic secretion by glucagon and D-glucose given intravenouslyQ71441367
Reversal of impaired GIP and insulin secretion in patients with pancreatogenic steatorrhea following enzyme substitutionQ72148637
Immunoreactive trypsin, α-amylase and lipase in serum — Is there an age-dependence?Q72662528
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Serum fat-soluble vitamin deficiency and abnormal calcium metabolism after malabsorptive bariatric surgeryQ75344686
Cytological characteristics of the exocrine pancreatic cells with regard to their position in relation to the islets of Langerhans. A study in normal and obese-hyperglycaemic miceQ79407580
Serum amylase and risk of the metabolic syndrome in Korean adultsQ84500700
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Potentiation of cholecystokinin-induced exocrine secretion by both exogenous and endogenous insulin in isolated and perfused rat pancreataQ35131520
Prevalence of exocrine pancreatic insufficiency in women with obesity syndrome: assessment by pancreatic fecal elastase 1Q35550907
Low Copy Number of the AMY1 Locus Is Associated with Early-Onset Female Obesity in FinlandQ35680010
High endogenous salivary amylase activity is associated with improved glycemic homeostasis following starch ingestion in adultsQ35892355
Functional regulation of sugar assimilation by N-glycan-specific interaction of pancreatic α-amylase with glycoproteins of duodenal brush border membraneQ36080467
Latent associations of low serum amylase with decreased plasma insulin levels and insulin resistance in asymptomatic middle-aged adults.Q36226381
Effects of bariatric surgery on glucose homeostasis and type 2 diabetesQ36292243
The pancreas as a single organ: the influence of the endocrine upon the exocrine part of the glandQ36587714
Chymase-mediated intestinal epithelial permeability is regulated by a protease-activating receptor/matrix metalloproteinase-2-dependent mechanismQ36699701
Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remainsQ36721554
Pancreas phylogeny and ontogeny in relation to a 'pancreatic stem cell'.Q36881907
Carbohydrate intake and obesityQ36997141
Protease-activated receptor 2 and gut permeability: a reviewQ37164684
Impact of Roux-en-Y gastric bypass surgery on rat intestinal glucose transportQ37421154
Mitogen-activated Protein Kinase Kinase Activity Maintains Acinar-to-Ductal Metaplasia and Is Required for Organ Regeneration in PancreatitisQ37585776
The islet-acinar axis of the pancreas: more than just insulinQ37731773
The role of dysregulated glucagon secretion in type 2 diabetesQ37913523
Acute pancreatitis due to diabetes: the role of hyperglycaemia and insulin resistance.Q38017784
The insulin-pancreatic acinar axisQ38152927
Glucagon and type 2 diabetes: the return of the alpha cell.Q38262673
Exocrine pancreatic insufficiency in diabetic patients: prevalence, mechanisms, and treatmentQ38429521
Experiments suggesting extra-digestive effects of enteral pancreatic amylase and its peptides on glucose homeostasis in a pig model.Q38619126
The serine protease-mediated increase in intestinal epithelial barrier function is dependent on occludin and requires an intact tight junctionQ38753779
Pancreatic α-Amylase Controls Glucose Assimilation by Duodenal Retrieval through N-Glycan-specific Binding, Endocytosis, and DegradationQ38869697
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The endocrine pancreas in chronic pancreatitis. Immunocytochemical and ultrastructural studiesQ39848710
Beneficial effect of a high number of copies of salivary amylase AMY1 gene on obesity risk in Mexican children.Q40234695
Development and regulation of porcine pancreatic functionQ40928689
A New Hypothesis for Insulin Resistance in Hypertension Due to Receptor CleavageQ41343627
Insulin resistance is accompanied by impairment of amylase-gene expression in the exocrine pancreas of the obese Zucker ratQ41913218
Do insulin and the insulin like growth factors (IGFs) stimulate growth of the exocrine pancreas?Q43183635
Development of exocrine pancreas function in chronically cannulated pigs during 1-13 weeks of postnatal lifeQ43521330
The enzyme levels in blood are not affected by oral administration of a pancreatic enzyme preparation (Creon 10,000) in pancreas-insufficient pigsQ44715484
Starch and glucose oligosaccharides protect salivary-type amylase activity at acid pH.Q44882623
The peri-insular acini of the pancreas of the ratQ45043315
Reduced β-Cell Secretory Capacity in Pancreatic-Insufficient, but Not Pancreatic-Sufficient, Cystic Fibrosis Despite Normal Glucose ToleranceQ47158498
Exocrine Pancreatic Insufficiency after Roux-en-Y gastric bypass.Q47860168
Induction of exocrine pancreas maturation at weaning in young developing pigs.Q50126821
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectpancreasQ9618
cellQ7868
human digestive systemQ9649
endocrine systemQ11078
carbohydrateQ11358
pathophysiologyQ1135939
diabetesQ12206
glucoseQ37525
P304page(s)55
P577publication date2018-10-08
P1433published inNutrition & DiabetesQ27723824
P1476titleGlucose homeostasis dependency on acini-islet-acinar (AIA) axis communication: a new possible pathophysiological hypothesis regarding diabetes mellitus
P478volume8

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cites work (P2860)
Q90539624Integrated Pancreatic Blood Flow: Bi-Directional Microcirculation Between Endocrine and Exocrine Pancreas
Q94586123The association of low serum salivary and pancreatic amylases with the increased use of lipids as an energy source in non-obese healthy women

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