Combined Experimental and System-Level Analyses Reveal the Complex Regulatory Network of miR-124 during Human Neurogenesis

scientific article published on 03 October 2018

Combined Experimental and System-Level Analyses Reveal the Complex Regulatory Network of miR-124 during Human Neurogenesis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CELS.2018.08.011
P932PMC publication ID6205824
P698PubMed publication ID30292704

P50authorVolker BusskampQ43100427
Johan JakobssonQ43194002
Jörg FallmannQ55473680
Deisy Morselli GysiQ93268283
P2093author name stringPeter F Stadler
Anka Swiersy
Shahryar Khattak
Karolina Pircs
Katja Nowick
Kerstin Lenk
Lisa K Kutsche
Rebecca Petri
Simon D Klapper
P2860cites workmiR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cellsQ21245271
Human MicroRNA targetsQ21563637
Heterogeneity of neural progenitor cells revealed by enhancers in the nestin geneQ22008708
Genome engineering using the CRISPR-Cas9 systemQ22122027
RNA-guided human genome engineering via Cas9Q24598394
Multiplex genome engineering using CRISPR/Cas systemsQ24609428
miRTarBase: a database curates experimentally validated microRNA-target interactionsQ24613026
The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicingQ24631683
MicroRNA-mediated switching of chromatin-remodelling complexes in neural developmentQ24632228
Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and CufflinksQ24633890
A mammalian microRNA expression atlas based on small RNA library sequencingQ24644709
The impact of microRNAs on protein outputQ24653549
The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS developmentQ24674190
A functional study of miR-124 in the developing neural tubeQ24680783
Mammalian microRNAs predominantly act to decrease target mRNA levelsQ27860535
Argonaute2 is the catalytic engine of mammalian RNAiQ27860545
Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targetsQ27860792
Identification of tissue-specific microRNAs from mouseQ27860892
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAsQ27861053
Enzymatic assembly of DNA molecules up to several hundred kilobasesQ28241142
Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modelingQ28488789
miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppressionQ28586443
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2Q29547403
An anatomically comprehensive atlas of the adult human brain transcriptomeQ29614949
DNA targeting specificity of RNA-guided Cas9 nucleasesQ29615793
A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexesQ29616620
A general framework for weighted gene co-expression network analysisQ29617580
Hierarchical organization of modularity in metabolic networksQ29618451
MicroRNA miR-124 regulates neurite outgrowth during neuronal differentiationQ30488466
Gene connectivity, function, and sequence conservation: predictions from modular yeast co-expression networksQ33235411
A novel microRNA and transcription factor mediated regulatory network in schizophreniaQ33531348
miR-124 regulates adult neurogenesis in the subventricular zone stem cell nicheQ42243673
Limitations and possibilities of small RNA digital gene expression profilingQ48069357
Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampusQ48266570
let-7 regulates radial migration of new-born neurons through positive regulation of autophagy.Q48367784
MiR-124 Promotes Newborn Olfactory Bulb Neuron Dendritic Morphogenesis and Spine DensityQ48403845
The miR-124 regulates the expression of BACE1/β-secretase correlated with cell death in Alzheimer's disease.Q48770351
miRNAs 182 and 183 are necessary to maintain adult cone photoreceptor outer segments and visual function.Q52651761
Positive feedback of DDX6/c-Myc/PTB1 regulated by miR-124 contributes to maintenance of the Warburg effect in colon cancer cells.Q52933028
wTO: an R package for computing weighted topological overlap and a consensus network with integrated visualization toolQ57790155
Differences in human and chimpanzee gene expression patterns define an evolving network of transcription factors in brainQ33564055
A viral microRNA down-regulates multiple cell cycle genes through mRNA 5'UTRsQ33619228
Sequencing bias: comparison of different protocols of microRNA library constructionQ33684046
Dissecting the role of non-coding RNAs in the accumulation of amyloid and tau neuropathologies in Alzheimer's disease.Q33862621
Characterization of small RNAs in Aplysia reveals a role for miR-124 in constraining synaptic plasticity through CREB.Q33873827
Transcriptional landscape of the prenatal human brainQ33926910
Gain, loss and divergence in primate zinc-finger genes: a rich resource for evolution of gene regulatory differences between speciesQ33955054
RNA-ligase-dependent biases in miRNA representation in deep-sequenced small RNA cDNA librariesQ33966769
A functional MiR-124 binding-site polymorphism in IQGAP1 affects human cognitive performanceQ34183590
miRWalk--database: prediction of possible miRNA binding sites by "walking" the genes of three genomesQ34186822
MicroRNA-mediated conversion of human fibroblasts to neurons.Q34200249
Reciprocal actions of REST and a microRNA promote neuronal identityQ34479303
Alterations in microRNA-124 and AMPA receptors contribute to social behavioral deficits in frontotemporal dementia.Q34642142
Increased serum levels of circulating exosomal microRNA-373 in receptor-negative breast cancer patientsQ34654554
Uses of banding techniques for the identification of human diseases of cytogenetic originQ34665699
Rapid neurogenesis through transcriptional activation in human stem cells.Q34987004
Transcriptional override: a regulatory network model of indirect responses to modulations in microRNA expressionQ35130693
Highly efficient Cas9-mediated transcriptional programmingQ35372727
MicroRNA-124 is a subventricular zone neuronal fate determinant.Q35614391
Functional Maturation of Human Stem Cell-Derived Neurons in Long-Term CulturesQ36239504
miRNA-target chimeras reveal miRNA 3'-end pairing as a major determinant of Argonaute target specificityQ36361054
MicroRNA miR124 is required for the expression of homeostatic synaptic plasticity.Q36392115
An alternative mode of microRNA target recognitionQ36522819
Executioner caspase-3 and caspase-7 are functionally distinct proteasesQ36861736
Argonaute2 expression is post-transcriptionally coupled to microRNA abundanceQ36915071
Hippocampal demyelination and memory dysfunction are associated with increased levels of the neuronal microRNA miR-124 and reduced AMPA receptorsQ36920474
miR-9 and miR-124 synergistically affect regulation of dendritic branching via the AKT/GSK3β pathway by targeting Rap2aQ36934310
Specific microRNAs modulate embryonic stem cell-derived neurogenesis.Q37020782
MicroRNAs as Neuronal Fate Determinants.Q38123452
The Cellular Phase of Alzheimer's DiseaseQ38731102
A Consensus Network of Gene Regulatory Factors in the Human Frontal LobeQ38834709
miR-124 represses ROCK1 expression to promote neurite elongation through activation of the PI3K/Akt signal pathway.Q39043278
miR-124-regulated RhoG reduces neuronal process complexity via ELMO/Dock180/Rac1 and Cdc42 signallingQ39347979
Identification of the miRNA targetome in hippocampal neurons using RIP-seqQ41539143
Tristetraprolin binding site atlas in the macrophage transcriptome reveals a switch for inflammation resolutionQ41710481
MicroRNA-128 governs neuronal excitability and motor behavior in miceQ41833350
P4510describes a project that usesImageJQ1659584
DESeq2Q113018293
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectneurogenesisQ1456827
P304page(s)438-452.e8
P577publication date2018-10-03
P1433published inCell SystemsQ27726426
P1476titleCombined Experimental and System-Level Analyses Reveal the Complex Regulatory Network of miR-124 during Human Neurogenesis
P478volume7

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cites work (P2860)
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Q93458865CRTDi005-Bdescribed by sourceP1343

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