Genomic and proteomic approaches for predicting toxicity and adverse drug reactions

article

Genomic and proteomic approaches for predicting toxicity and adverse drug reactions is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1517/17425250802661895
P698PubMed publication ID19236227

P50authorQing-Yu HeQ37837220
Feng GeQ59692119
P2093author name stringFeng Ge
Qing-Yu He
P2860cites work8-plex quantitation of changes in cerebrospinal fluid protein expression in subjects undergoing intravenous immunoglobulin treatment for Alzheimer's diseaseQ24606651
The comparative toxicogenomics database: a cross-species resource for building chemical-gene interaction networksQ24673368
Applications of microarray technology in breast cancer researchQ24801392
Protein expression profiling arrays: tools for the multiplexed high-throughput analysis of proteinsQ24805115
Mechanisms of benzene-induced hematotoxicity and leukemogenicity: cDNA microarray analyses using mouse bone marrow tissueQ24815877
Toxicoproteomics: a parallel approach to identifying biomarkersQ24815922
Functional discovery via a compendium of expression profilesQ27938962
Large-scale analysis of the yeast proteome by multidimensional protein identification technologyQ28131778
Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patientsQ28169189
Clustering of hepatotoxins based on mechanism of toxicity using gene expression profilesQ28213099
Quantitative mass spectrometry in proteomics: a critical reviewQ28238800
Quantitative profiling of differentiation-induced microsomal proteins using isotope-coded affinity tags and mass spectrometryQ28360826
Peer Reviewed: SELDI-TOF MS for Diagnostic ProteomicsQ29041901
Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studiesQ29616299
Mass spectrometry as a diagnostic and a cancer biomarker discovery tool: opportunities and potential limitationsQ30751781
A prototype methodology combining surface-enhanced laser desorption/ionization protein chip technology and artificial neural network algorithms to predict the chemoresponsiveness of breast cancer cell lines exposed to Paclitaxel and Doxorubicin undeQ30788689
Proteomic analysis of differential protein expression in primary hepatocytes induced by EGF, tumour necrosis factor alpha or the peroxisome proliferator nafenopin.Q30886686
Predictive models of hepatotoxicity using gene expression data from primary rat hepatocytesQ31079345
CEBS--Chemical Effects in Biological Systems: a public data repository integrating study design and toxicity data with microarray and proteomics data.Q31134298
Evaluation of serum protein profiling by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry for the detection of prostate cancer: I. Assessment of platform reproducibilityQ31136536
Imaging mass spectrometry: principles and potentialsQ33213530
Correcting common errors in identifying cancer-specific serum peptide signaturesQ33221189
Proteomic approach to study the cytotoxicity of dioscin (saponin).Q33237029
Microarrays and toxicology: the advent of toxicogenomicsQ33594789
Genomic analysisQ33884928
Genomics and proteomics: the new millennium of drug discovery and developmentQ34198848
The ABC's (and XYZ's) of peptide sequencingQ34344848
Toxicology and genetic toxicology in the new era of "toxicogenomics": impact of "-omics" technologiesQ34502685
Use of proteomics for the discovery of early markers of drug toxicity.Q34698617
Relative quantification of proteins in human cerebrospinal fluids by MS/MS using 6-plex isobaric tagsQ34756963
Adapting arrays and lab-on-a-chip technology for proteomicsQ34775306
The role of proteomics in toxicology: identification of biomarkers of toxicity by protein expression analysisQ34780567
Protein arrays: the current state-of-the-artQ35053985
Recent developments in protein microarray technologyQ35060489
Protein analysis on a proteomic scaleQ35084572
Generation of bioreagents for protein chipsQ35574632
Progress in applying genomics in drug developmentQ35749343
DNA microarrays as a tool in toxicogenomicsQ35768455
Toxicoproteomics: proteomics applied to toxicology and pathologyQ35973576
Drug-induced oxidative stress in rat liver from a toxicogenomics perspectiveQ36176702
How can toxicogenomics inform risk assessment?Q36180126
Toxicogenomics in risk assessment: applications and needsQ36284819
Proteomics approach to illustrate drug action mechanisms.Q36740592
Chemical and pathway proteomics: powerful tools for oncology drug discovery and personalized health care.Q37234005
Acute molecular markers of rodent hepatic carcinogenesis identified by transcription profilingQ38422575
Prediction of compound signature using high density gene expression profilingQ38456725
Admissions caused by adverse drug events to internal medicine and emergency departments in hospitals: a longitudinal population-based studyQ39608974
Proteomic analysis of chromium cytotoxicity in cultured rat lung epithelial cellsQ39970899
Identification of in vitro protein biomarkers of idiosyncratic liver toxicityQ40512122
A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening systemQ40519669
An information-intensive approach to the molecular pharmacology of cancer.Q41134023
Simultaneous measurement of hundreds of liver proteins: application in assessment of liver functionQ41137503
EDGE: a centralized resource for the comparison, analysis, and distribution of toxicogenomic informationQ42645749
Discriminating the molecular basis of hepatotoxicity using the large-scale characteristic molecular signatures of toxicants by expression profiling analysisQ43560308
Microarray analysis of hepatotoxins in vitro reveals a correlation between gene expression profiles and mechanisms of toxicityQ43588948
RNA expression in the early characterization of hepatotoxicants in Wistar rats by high-density DNA microarraysQ43601218
Prediction of torsade-causing potential of drugs by support vector machine approach.Q44771784
A novel method for visualizing nuclear hormone receptor networks relevant to drug metabolismQ45193691
In vivo hepatotoxicity study of rats in comparison with in vitro hepatotoxicity screening systemQ46990864
Web-based tools for mining the NCI databases for anticancer drug discovery.Q47245928
ProteoChip: a highly sensitive protein microarray prepared by a novel method of protein immobilization for application of protein-protein interaction studies.Q51598544
Profiling the hepatic effects of flutamide in rats: a microarray comparison with classical aryl hydrocarbon receptor ligands and atypical CYP1A inducers.Q51810783
Toxicogenomics strategies for predicting drug toxicity.Q51930594
Applying toxicogenomics in mechanistic and predictive toxicology.Q53627418
Protein labeling by iTRAQ: A new tool for quantitative mass spectrometry in proteome researchQ57830708
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)29-37
P577publication date2009-01-01
P1433published inExpert Opinion on Drug Metabolism & ToxicologyQ5421205
P1476titleGenomic and proteomic approaches for predicting toxicity and adverse drug reactions
P478volume5

Reverse relations

cites work (P2860)
Q42712058Genomic biomarkers for cardiotoxicity in rats as a sensitive tool in preclinical studies
Q42577709LNO3 AND L3 Are Associated With Antiproliferative And Pro-Apoptotic Action In Hepatoma Cells
Q37677046Omics in mechanistic and predictive toxicology
Q58302428Technological Advancements in Mass Spectrometry and Its Impact on Proteomics
Q34296800The determination and interpretation of the therapeutic index in drug development
Q37767386The future of toxicity testing
Q38317697The role of microRNAs in toxicology

Search more.